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October 10, 2017; 89 (15) Editorial

Preventing multiple sclerosis

To (take) vitamin D or not to (take) vitamin D?

Ruth Ann Marrie, Christopher A. Beck
First published September 13, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004506
Ruth Ann Marrie
From the Departments of Internal Medicine and Community Health Sciences (R.A.M.), University of Manitoba, Canada; and Department of Biostatistics and Computational Biology (C.A.B.), University of Rochester Medical Center, NY.
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Christopher A. Beck
From the Departments of Internal Medicine and Community Health Sciences (R.A.M.), University of Manitoba, Canada; and Department of Biostatistics and Computational Biology (C.A.B.), University of Rochester Medical Center, NY.
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Preventing multiple sclerosis
To (take) vitamin D or not to (take) vitamin D?
Ruth Ann Marrie, Christopher A. Beck
Neurology Oct 2017, 89 (15) 1538-1539; DOI: 10.1212/WNL.0000000000004506

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Over 2 million persons worldwide have multiple sclerosis (MS),1 and the burden of the disease for affected individuals and society is substantial. A recent study estimated that by 2031, 133,635 Canadians would be living with MS, and that the direct costs of their care would reach a staggering $2 billion annually.2 Therefore, identifying modifiable risk factors for MS remains vitally important. Researchers still seek to firmly demonstrate a causal role for vitamin D, a biologically plausible etiologic factor which is modifiable. Vitamin D receptors are ubiquitous, being expressed on immune cells and in the CNS; immune responses are affected by variations in 25-hydroxyvitamin D (25[OH]D) levels; and 1,25-dihydroxycholecaliferol can prevent the emergence of experimental autoimmune encephalomyelitis,3,4 an animal model of demyelinating disease. However, epidemiologic studies have often been hindered by the inability to demonstrate temporality; that is, that the exposure to inadequate 25(OH)D occurred before the onset of MS.

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  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

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  • © 2017 American Academy of Neurology
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