Abstract
Objective: Quality of neurologic emergency management in an under-resourced country may be improved by standard operating procedures (SOPs).
Methods: Neurologic SOPs were implemented in a large urban (Banjul) and a small rural (Brikama) hospital in the Gambia. As quality indicators of neurologic emergency management, performance of key procedures was assessed at baseline and in the first and second implementation years.
Results: At Banjul, 100 patients of the first-year intervention group exhibited higher rates of general procedures of emergency management than 105 control patients, such as neurologic examination (99.0% vs 91.4%; p < 0.05) and assessments of respiratory rate (98.0% vs 81.9%, p < 0.001), temperature (60.0% vs 36.2%; p < 0.001), and glucose levels (73.0% vs 58.1%; p < 0.05), in addition to written directives by physicians (96.0% vs 88.6%, p < 0.05), whereas assessments of other vital signs remained unchanged. In stroke patients, rates of stroke-related procedures increased: early CT scanning (24.3% vs 9.9%; p < 0.05), blood count (73.0% vs 49.3%; p < 0.01), renal and liver function tests (50.0% vs 5.6%, p < 0.001), aspirin prophylaxis (47.3% vs 9.9%; p < 0.001), and physiotherapy (41.9% vs 4.2%; p < 0.001). Most effects persisted until the second-year evaluation. SOP implementation was similarly feasible and beneficial at the Brikama hospital. However, outcomes did not significantly differ in the hospitals.
Conclusions: Implementing SOPs is a realistic, low-cost option for improving process quality of neurologic emergency management in under-resourced settings.
Classification of evidence: This study provides Class IV evidence that, for patients with suspected neurologic emergencies in sub-Saharan Africa, neurologic SOPs increase the rate of performance of guideline-recommended procedures.
GLOSSARY
- CBC=
- complete blood count;
- GOS=
- Glasgow Outcome Scale;
- mRS=
- modified Rankin Scale;
- SOP=
- standard operating procedure
Acute neurologic diseases are an important cause of disability and death in sub-Saharan Africa, a region with approximately 800 million people and one of the poorest in the world.1,–,3 They result in large costs for families and societies, further impeding the economic progress of these countries.4,5
Common neurologic emergencies in sub-Saharan Africa are cerebrovascular diseases, meningoencephalitis, and epileptic seizures. Cerebrovascular diseases are increasingly frequent and associated with a poor outcome.6,–,13 Moreover, meningoencephalitis is frequent (meningitis belt)5,14,15 and associated with high mortality.16 Also, epilepsy frequently manifests itself as a neurologic emergency,16 with status epilepticus being an important cause of premature death among these patients.17,–,19
Despite the enormous recent advancement in the field of acute neurology, most patients in developing countries do not profit from this.1,17,20,–,24 There, acute neurologic patients usually do not receive evidence-based treatments that are standard in the Western world.25,–,33 An important reason is the scarcity of neurologists and neurologic services.1,17,20,–,24 Indeed, many countries such as the Gambia have none at all.24
Because there is only a small likelihood that sub-Saharan African countries will possess the financial resources necessary for overcoming this treatment gap, an immediately realizable and low-cost option may be to make better use of the limited available resources. Standard operating procedures (SOPs) may prevent undesirable variations in the treatment of otherwise similar cases and assist in streamlining processes. Here, we studied the effects of SOPs on the quality of neurologic emergency management in a resource-poor sub-Saharan setting.
METHODS
Setting and patients.
This interventional study was performed in the Gambia, a small sub-Saharan African country with approximately 1,900,000 inhabitants. The study was performed simultaneously in a large urban teaching hospital (The Edward Francis Small Teaching Hospital, Banjul, with 500 beds, treating approximately 25,000 patients annually) and in a small rural hospital (Brikama Major Health Centre, with 54 beds, treating approximately 12,000 patients annually).
Inclusion criteria were (1) suspected neurologic emergencies, defined as conditions manifesting themselves as acute symptoms severe enough to require immediate medical attention, (2) age ≥14 years, and (3) provision of informed written consent by patients or closest proxies. Exclusion criteria were nonacute conditions and traumatic brain injuries.
Study design.
In a stepwise approach, we first obtained by use of a questionnaire a baseline of quality indicators of neurologic emergency management in consecutive patients over a study period of 8 weeks (February 11–April 1, 2014) in Banjul and Brikama. We implemented SOPs for neurologic emergency management on October 1, 2014 (table 1).
Standard operating procedures (SOPs) for general and syndrome-specific neurologic emergency managementa
The intervention was implemented via the following training activities. (1) One intensive training session for the Gambian teachers (L.E.S.J., A.J., C.S.) in Germany for approximately 4 weeks. (2) Four larger onsite group sessions for training all physicians and nurses in the use of the SOPs. The first took place before the introduction of the SOPs, and the refresher training sessions took place approximately every 6 months. (3) At these meetings, apart from oral presentations, laminated pocket cards of the SOPs (one for each syndrome entity) and further written explanations were distributed to all involved physicians and medical students in the Department of Medicine by L.E.S.J., A.J., S.A.H., and C.S. (4) Moreover, during morning conferences attended by all relevant physicians, information about the use of the neurologic SOPs was repeated, and interesting cases were presented approximately monthly.
The assessment using the same questionnaires was, in the same season, repeated in 2015 (March 9–April 29) in both hospitals and in 2016 (February 24–April 20) in Banjul alone. Enrollment and assessment of patient management were performed by dedicated study investigators (visiting and local physicians not engaged in routine services, e.g., on maternity leave), whose role was strictly observational. Study visits occurred at admission, on day 5 (±1 day), and at discharge. This study with a before–after design aimed to provide Class IV evidence for the effects of implementation of neurologic SOPs on quality indicators of neurologic emergency management.
SOPs for neurologic emergency management.
In a series of meetings in the Gambia and in Germany, followed by e-mail discussions, participants in both cooperating groups (L.E.S.J., S.A.H., A.J., A.R.-S., S.W., S.B., V.S., O.N., and K.F.) reviewed the current international25,27,28,30,–,32 and South African guidelines26,29,33 regarding the following neurologic emergency entities: stroke, meningitis/encephalitis, and seizures. Measures (1) that did not address acute management and (2) for which there was consensus that they were not feasible or were without therapeutic consequences in this specific sub-Saharan study setting were not considered for this SOP intervention.
The SOPs addressed both general procedures for neurologic emergency management and syndrome-specific procedures. The SOP general neurologic emergency management (table 1) addressed the fastest possible neurologic examination and assessment of vital signs, blood glucose level, and ECG, apart from structured storage and maintenance of neurologic equipment. For the identification of neurologic emergencies in a setting without neurologists, we developed a tool that screens for acute neurologic symptoms (Gambia neurologic emergency screen; table 1).
The SOP stroke (table 1) was to be used for patients with acute focal neurologic symptoms or stupor and coma. If symptoms that had occurred within the previous 24 hours and still persisted or fluctuated at admission, or if stupor or coma was present (defining a high priority level), the SOP recommended the fastest possible CT scan, complete blood count (CBC), and laboratory tests for renal and liver function to be carried out (table 1). If the cause of reduced consciousness remained unclear after CT evaluation, the SOP recommended CSF analysis and toxicologic screening tests. Therapeutically, after CT scan, the SOP mandated early secondary prevention with aspirin (100 mg), blood pressure management, and physiotherapy.
The SOP fever and headache (table 1) recommended CBC and, optionally, a CT scan. If meningeal signs were present at admission (high priority level), tests of CSF and of renal and liver function were recommended. An antibiotic treatment regimen was specified.
For patients with seizures, the SOP seizures (table 1) was used. If seizures were present at admission (high priority level), the SOP mandated a CT scan and laboratory tests (CBC, renal and liver function) and if the cause still remained unclear, CSF analysis and toxicologic tests were recommended. An anticonvulsive treatment was specified.
Indicators of quality of neurologic emergency management.
As indicators of quality of general neurologic emergency management, we assessed performance of guideline-recommended procedures: neurologic examinations, assessment of vital signs, and performance of blood glucose tests and ECG (table 1), in addition to written directives by a physician.
As indicators of quality of stroke-specific neurologic emergency management, we used, in addition, performance of early CT scan, hepatic and renal laboratory tests, early secondary aspirin prophylaxis (after CT), blood pressure management, and physiotherapy. As quality indicators of management of patients with the syndromes fever and headache and seizures, we analyzed the performance of recommended blood and CSF tests, imaging, toxicologic screening, and the administration of antibiotics or anticonvulsants.
Finally, we assessed mortality, Glasgow Outcome Scale (GOS) scores, modified Rankin Scale (mRS) scores, and NIH Stroke Scale scores (for stroke patients) at discharge.
Monitoring of the study.
The trial was monitored by an independent clinical monitor (Interdisciplinary Centre for Clinical Trials, Mainz, Germany). Source data were compared with both questionnaires and databases. For remote monitoring in Germany, the original patient files were photographed at the study site and then destroyed after the subsequent monitoring process in Germany.
Standard protocol registrations, approvals, and patient consents.
The study and the subject information documents were approved by the Medical Research Council Ethics Committee of the Gambia (R 130013). All patients provided written informed consent (in their native language) to participate in the study. For patients aged 14–18 years, or those with a communication disability, written informed consent was obtained from the closest proxies.
Statistical analysis.
Differences between the study groups were detected with the Mann-Whitney U test. The χ2 test and Fisher exact test were used to analyze categorical variables. IBM SPSS Statistics for Windows, version 23.0.0.2 (IBM, Armonk, NY), software was used.
RESULTS
Study population at the Banjul hospital.
In the urban hospital at Banjul, 152 patients during the baseline assessment in 2014 were screened for possible study participation, and 105 were enrolled in the study as the baseline group. In 2015, 145 patients were screened for inclusion, and 100 were enrolled. During the study period in 2016, 80 patients were screened for inclusion, and 71 were included (figure 1).
Demographic variables, risk factor profiles, referral status, disease severity, and pattern of suspected initial and final diagnoses (table 2) and sociodemographic details (table e-1 at Neurology.org) of the study populations in the Banjul hospital were within the same range. In all study groups, stroke was the most common suspected and final diagnosis. In contrast, although meningoencephalitis and seizures were more frequently suspected at admission, they were unexpectedly rare final diagnoses (table 2), impairing further statistical evaluation of these diagnostic subgroups.
Demographic and medical variables of the study groups at the Banjul hospital and the Brikama hospital
Effects on quality of general neurologic emergency management at the Banjul hospital.
Performance of key procedures of general neurologic emergency management in the first intervention year (neurologic examination, assessments of respiratory rates, temperature, and glucose level, and written directives by a physician) and in the second intervention year (assessment of respiratory rate and glucose level and written directives by a physician) were higher than at baseline (table 3). In contrast, the rates of assessing blood pressure and heart rate, which had already been >95% at baseline, did not improve further. The rate of performance of ECG, however, was lower in 2015 and 2016 than in 2014 because of problems with the supply of ECG paper (table 3).
Rates of performance of general procedures of neurologic emergency management and outcomes at the Banjul hospital
Effects on quality of stroke-related emergency management at the Banjul hospital.
The rates of performance of stroke-specific neurologic procedures were higher in both intervention groups than in the baseline group (table 4). In contrast to the total number of CTs, the number of CTs performed within 8 hours (urgent CT) was significantly higher in the first-year intervention group than in the baseline group, a finding that was also related to these patients' placement in the high-priority group (table 4). However, in the second-year intervention group, the rate of urgent CTs did not differ. Laboratory examinations (CBC and renal and liver function tests) were performed significantly more often during the first and second years of intervention. The proportion of early secondary prevention with aspirin (after CT scanning) was approximately 5 times higher in the first-year and in the second-year intervention groups than in the baseline group (table 4). Rate of administration of antihypertensives tended to be higher in the first year and was significantly higher in the second year. Importantly, the proportion of patients for whom physiotherapy was performed was approximately 10 times higher in both the first-year and second-year intervention groups than in the baseline group (table 4).
Rates of performance of stroke-specific procedures and outcomes at the Banjul hospital
Effects on clinical outcomes at the Banjul hospital.
Clinical outcomes (as determined by GOS scores, mRS scores, and mortality rates) at discharge showed a trend toward improvement that was not statistically significant (tables 3 and 4).
Effects of SOPs at the Brikama hospital.
The SOP intervention was performed in parallel at the rural hospital in Brikama, where 49 patients were screened for possible study participation, and 28 were enrolled in the study as a baseline group. During the study period in 2015, 36 patients were screened for inclusion, and 25 were enrolled as an intervention group (figure e-1). Demographic and medical profiles (table 2) and additional socioepidemiologic details (table e-1) were within the same range. No patient in Brikama was treated according to more than one SOP.
In this rural hospital, the rates of performance of most (heart rate, respiratory rate, temperature, blood glucose level) but not all (blood pressure, ECG, and written directive by a physician) procedures of general neurologic emergency management were significantly higher in the intervention group than in the baseline group (table e-2). Among patients with suspected stroke and of a high priority level, 4 from the intervention group had CT scan (after transfer to the Banjul hospital) in contrast to none in the baseline group (table e-3). In Brikama, although the rate of general aspirin prevention was unchanged, the rate of CT-confirmed aspirin prevention relatively increased. The rates of blood pressure measurement and medication and of physiotherapy were not significantly different (table e-3). At Brikama, no significant differences were observed in mortality rates or clinical outcomes between the 2 groups (tables e-2 and e-3).
DISCUSSION
Enormous advances have been made in the treatment of acute neurologic diseases; however, in developing countries, most neurologic patients cannot benefit from this progress. This study conducted in 2 exemplary urban and rural hospitals shows that, in an under-resourced sub-Saharan country without neurologists, the implementation of SOPs significantly improves the quality of general and syndrome-specific neurologic emergency management.
In this study, acute stroke composed the majority of neurologic emergencies, whereas the proportion of acute brain infections or seizures was unexpectedly low. The very high prevalence of cerebrovascular diseases in developing countries has previously been placed in context with shift toward increased prevalence of vascular risk factors.2,11,–,13,34
When stroke was suspected, guideline-recommended performance of urgent (≤8 hours) CT increased in relation to the priority level, although this effect was evident only in the first but not the second intervention year.
Laboratory tests (CBC, renal and hepatic function test) were performed significantly more frequently in both intervention years than at baseline.
Despite being recommended in stroke guidelines,25,–,27 aspirin, an inexpensive and effective prophylactic treatment, is usually not administered after exclusion of hemorrhage by CT or not administered at all in developing countries.35 Although secondary prevention with aspirin without exclusion of hemorrhage has recently been calculated to be cost-effective,36 imaging clearly increases the safety of this antithrombotic treatment. In our study, implementation of the SOPs was associated with an approximately 5-fold increase in the frequency of aspirin prophylaxis with prior exclusion of hemorrhage by CT. The use of aspirin ≤48 hours, although still significantly increased, decreased from year 1 to year 2, a finding that may be related to the fact that the rate of urgent CTs needed for previous exclusion of hemorrhage also decreased.
Finally, physiotherapy is recommended for reducing disability and preventing complications such as pneumonia or deep venous thrombosis.25,–,27 Importantly, approximately 10 times more stroke patients in the intervention group than in the baseline group received physiotherapy, an effect that persisted in the second-year evaluation.
The SOP intervention was performed in parallel at Brikama, a small rural hospital. There, we observed similar beneficial effects of the SOPs on rates of procedures of neurologic emergency management, a finding suggesting generalizability of the strategy of neurologic SOPs for under-resourced settings. It might be of interest to study whether, more generally, such SOPs may also be useful in other areas of medical care, e.g., in management of other major medical problems of this region such as HIV/AIDS and malaria, although, as chronic diseases, they were beyond the focus of this study on neurologic emergency management.
In all study groups, mortality rates associated with neurologic emergencies were approximately 40%, consistent with rates found by earlier studies.8,–,10,15,17,–,19 Although a trend toward better clinical outcomes was observed, these differences did not reach statistical significance. Recently, in the neurology unit of a Ugandan hospital, a stroke pathway for patients with CT-diagnosed stroke was implemented; this pathway, combined with the provision of missing resources, slightly improved certain outcomes only in a subpopulation of patients with severe strokes.37
One limitation of this study is the lack of randomization to treatment protocols that did not appear to be feasible in this sub-Saharan African setting for ethical reasons. Moreover, people may tend to function better when they are being observed. However, the conditions of the assessments before and after the SOP implementation were identical, thereby limiting this potential bias. A further limitation is that the neurologic screening tool was not validated in an additional study. In contrast to analysis of time intervals and rates of procedures in which significant differences were found, the power for the analysis of the multifactorial endpoint, outcome, was likely too low. Rather than specific power calculations, only rough estimations have been performed in advance. Differences in outcomes might have been seen with a longer follow-up period, although long-term follow-up is difficult in such settings.
Also, the relevance of certain laboratory tests, such as of renal function, is uncertain in this setting. Reasons for including them were mostly to exclude regionally relevant non-neurologic conditions that may have contributed to the patients' clinical presentation due to the high frequency of renal failure as consequence of uncontrolled hypertension, diabetes, chronic glomerulonephritis, and herbal intoxication and frequent hepatitis associated with an estimated prevalence of hepatitis B viral infection up to 30%.
The existing financial constrains became overt as both timely provision of expensive resources, such as urgent CT, for which financial questions often had to be settled, and the continuous supply of more specialized consumables, such as ECG paper, was hindered. Thus, neurologic SOPs are only one of several necessary steps, among which include long-term international financial support and cooperation; structural measures, such as health insurance systems and systematic training of neurologists (thereby avoiding brain drain); and, finally, implementing neurologic services.23,24 All of these steps have previously been defined as goals by the World Federation of Neurology.21
The results of this study show that neurologic SOPs in a sub-Saharan African country have long-term beneficial effects on the quality of neurologic emergency management, even in the absence of provision of additional resources. This finding offers a realistic and low-cost option for reducing the detrimental treatment gap for acute neurologic patients in highly under-resourced settings.
AUTHOR CONTRIBUTIONS
Lamin E.S. Jaiteh: study organization and execution and manuscript review and critique. Stefan A. Helwig: study organization and execution and manuscript review and critique. Abubacarr Jagne: study organization and execution and manuscript review and critique. Andreas Ragoschke-Schumm: study organization and execution and manuscript review and critique. Catherine Sarr: study execution and manuscript review and critique. Silke Walter: study organization and execution and manuscript review and critique. Martin Lesmeister: statistical analysis and manuscript review and critique. Matthias Manitz: study execution and manuscript review and critique. Sebastian Blaß: study organization, execution, manuscript review and critique. Sarah Weis: study execution, manuscript review and critique. Verena Schlund: study execution, manuscript review and critique. Neneh Bah: organization and execution. Jil Kauffmann: study execution, manuscript review and critique. Matthias Fousse: study organization, manuscript review and critique. Sabina Kangankan: study organization and execution. Asmell Ramos Cabrera: organization and execution. Kai Kronfeld: study conception, statistical design, manuscript review and critique. Christian Ruckes: study conception, statistical design, manuscript review and critique. Yang Liu: study organization, manuscript review and critique. Ousman Nyan: study conception, manuscript review and critique. Klaus Fassbender: study conception, organization, execution, manuscript writing, review, and critique.
STUDY FUNDING
Supported by the Else Kröner–Fresenius–Stiftung. The Article Processing Charge was funded by the University of the Saarland, Germany.
DISCLOSURE
The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
Footnotes
↵* These authors contributed equally to this work.
Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was funded by the authors.
Supplemental data at Neurology.org
- Received October 6, 2016.
- Accepted in final form April 11, 2017.
- Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
REFERENCES
Letters: Rapid online correspondence
- Author response to Dr. Chin
- Neurologic emergency management in resource-challenged settings: Can standard operating procedures work and improve outcomes?
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