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November 14, 2017; 89 (20) ArticleOpen Access

The social and economic burden of frontotemporal degeneration

James E. Galvin, David H. Howard, Sharon S. Denny, Susan Dickinson, Nadine Tatton
First published October 4, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004614
James E. Galvin
From the Institute for Healthy Aging and Lifespan Studies (J.E.G.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton; Emory University (D.H.H.), Atlanta, GA; and Association for Frontotemporal Degeneration (S.S.D., S.D., N.T.), Radnor, PA.
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David H. Howard
From the Institute for Healthy Aging and Lifespan Studies (J.E.G.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton; Emory University (D.H.H.), Atlanta, GA; and Association for Frontotemporal Degeneration (S.S.D., S.D., N.T.), Radnor, PA.
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Sharon S. Denny
From the Institute for Healthy Aging and Lifespan Studies (J.E.G.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton; Emory University (D.H.H.), Atlanta, GA; and Association for Frontotemporal Degeneration (S.S.D., S.D., N.T.), Radnor, PA.
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Susan Dickinson
From the Institute for Healthy Aging and Lifespan Studies (J.E.G.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton; Emory University (D.H.H.), Atlanta, GA; and Association for Frontotemporal Degeneration (S.S.D., S.D., N.T.), Radnor, PA.
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Nadine Tatton
From the Institute for Healthy Aging and Lifespan Studies (J.E.G.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton; Emory University (D.H.H.), Atlanta, GA; and Association for Frontotemporal Degeneration (S.S.D., S.D., N.T.), Radnor, PA.
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Citation
The social and economic burden of frontotemporal degeneration
James E. Galvin, David H. Howard, Sharon S. Denny, Susan Dickinson, Nadine Tatton
Neurology Nov 2017, 89 (20) 2049-2056; DOI: 10.1212/WNL.0000000000004614

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Article Information

vol. 89 no. 20 2049-2056
DOI: 
https://doi.org/10.1212/WNL.0000000000004614
PubMed: 
28978658

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 1, 2017
  • Accepted in final form August 25, 2017
  • First Published October 4, 2017.

Article Versions

  • Previous version (October 4, 2017 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. James E. Galvin, MD, MPH,
    2. David H. Howard, PhD,
    3. Sharon S. Denny, MA,
    4. Susan Dickinson, MSGC and
    5. Nadine Tatton, PhD
  1. James E. Galvin, MD, MPH,
  2. Scientific Advisory Boards:
    1. Phase 2 double-blind, placebo-controlled trial of Nilotinib in patients with mild to moderate AD. PI: R. Scott Turner, MD (Sponsor: Alzheimer Drug Discovery Foundation) 2016-present; Role: Chair, DSMB Glutamatergic Dysfunction in Cognitive Aging: Riluzole in Mild Alzheimer Disease. PI: Ana Pereira, MD (Sponsor: Alzheimer Drug Discovery Foundation) 2012-present; Role: Chair, DSMB A Preliminary Study of Carvedilol for the treatment of Alzheimer?s Disease (R01 AG00035546) PI: Paul Rosenberg, MD. (Sponsor: National Institute on Aging) 2011-present, Role: Member, DSMB

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. Alzheimer disease and associated disorders, editorial board, 2005- present Neurodegenerative disease management, editorial board, 2012-present

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Axovant Biogen Lilly Eisai

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Axovant - clinical trial Biogen - clinical trial

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. David H. Howard, PhD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. International Journal of Health Economics and Management, Editor-in-Chief, 2017

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Association for Frontotemporal Degeneration The Center for Discovery

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. National Institutes of Health, PI, R01CA208758-01A1, 2017- Agency for Healthcare Research and Quality, PI, R03HS24613-01, 2016

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. Robert Wood Johnson Foundation, 73800

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Sharon S. Denny, MA,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Susan Dickinson, MSGC and
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Nadine Tatton, PhD
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. (1) US 7,160,857 Tatton et al. Methods for increasing Schwann cell survival are disclosed. The methods of the invention are useful for the treatment of conditions such as peripheral neuropathies, including diabetic neuropathies.The present invention provides methods for increasing Schwann cell survival in a patient or in vitro, or for treating a peripheral neuropathy in a subject suffering from, or susceptable to, a peripheral neuropathy. (2) US 6,492,427 Shankar et al. Methods for treating multiple sclerosis. Methods for increasing oligodendrocyte survival are disclosed. The methods of the invention are useful for the treatment of Multiple Sclerosis. It has now been discovered that certain compounds are capable of increasing survival of oligodendrocytes. The invention provides methods for increasing survival of oligodendrocytes both in vivo and in vitro, of preventing or inhibiting death of oligodendrocytes, of preventing or inhibiting the progression of Multiple Sclerosis, and methods for treating Multiple Sclerosis.

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Institute for Healthy Aging and Lifespan Studies (J.E.G.), Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton; Emory University (D.H.H.), Atlanta, GA; and Association for Frontotemporal Degeneration (S.S.D., S.D., N.T.), Radnor, PA.
  1. Correspondence to Dr. Galvin: galvinj{at}health.fau.edu
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