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November 28, 2017; 89 (22) Article

Assessing association of comorbidities with treatment choice and persistence in MS

A real-life multicenter study

Alice Laroni, Alessio Signori, Giorgia T. Maniscalco, Roberta Lanzillo, Cinzia Valeria Russo, Eleonora Binello, Salvatore Lo Fermo, Annamaria Repice, Pietro Annovazzi, Simona Bonavita, Marinella Clerico, Damiano Baroncini, Luca Prosperini, Sara La Gioia, Silvia Rossi, Eleonora Cocco, Jessica Frau, Valentina Torri Clerici, Elisabetta Signoriello, Arianna Sartori, Ignazio Roberto Zarbo, Sarah Rasia, Cinzia Cordioli, Raffaella Cerqua, Alessia Di Sapio, Luigi Lavorgna, Simona Pontecorvo, Caterina Barrilà, Francesco Saccà, Barbara Frigeni, Sabrina Esposito, Domenico Ippolito, Fabio Gallo, Maria Pia Sormani
First published November 1, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004686
Alice Laroni
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Alessio Signori
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Giorgia T. Maniscalco
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Roberta Lanzillo
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Cinzia Valeria Russo
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Eleonora Binello
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Salvatore Lo Fermo
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Annamaria Repice
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Pietro Annovazzi
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Simona Bonavita
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Marinella Clerico
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Damiano Baroncini
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Luca Prosperini
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Sara La Gioia
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Silvia Rossi
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Eleonora Cocco
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Jessica Frau
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Valentina Torri Clerici
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Elisabetta Signoriello
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Arianna Sartori
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Ignazio Roberto Zarbo
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Sarah Rasia
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Cinzia Cordioli
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Raffaella Cerqua
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Alessia Di Sapio
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Luigi Lavorgna
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Simona Pontecorvo
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Caterina Barrilà
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Francesco Saccà
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Barbara Frigeni
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Sabrina Esposito
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Domenico Ippolito
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Fabio Gallo
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Maria Pia Sormani
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Citation
Assessing association of comorbidities with treatment choice and persistence in MS
A real-life multicenter study
Alice Laroni, Alessio Signori, Giorgia T. Maniscalco, Roberta Lanzillo, Cinzia Valeria Russo, Eleonora Binello, Salvatore Lo Fermo, Annamaria Repice, Pietro Annovazzi, Simona Bonavita, Marinella Clerico, Damiano Baroncini, Luca Prosperini, Sara La Gioia, Silvia Rossi, Eleonora Cocco, Jessica Frau, Valentina Torri Clerici, Elisabetta Signoriello, Arianna Sartori, Ignazio Roberto Zarbo, Sarah Rasia, Cinzia Cordioli, Raffaella Cerqua, Alessia Di Sapio, Luigi Lavorgna, Simona Pontecorvo, Caterina Barrilà, Francesco Saccà, Barbara Frigeni, Sabrina Esposito, Domenico Ippolito, Fabio Gallo, Maria Pia Sormani
Neurology Nov 2017, 89 (22) 2222-2229; DOI: 10.1212/WNL.0000000000004686

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Abstract

Objective: To assess whether the presence of concomitant diseases at multiple sclerosis (MS) diagnosis is associated with the choice and the treatment persistence in an Italian MS cohort.

Methods: We included newly diagnosed patients (2010–2016) followed in 20 MS centers and collected demographic and clinical data. We evaluated baseline factors related to the presence of comorbidities and the association between comorbidities and the clinical course of MS and the time to the first treatment switch.

Results: The study cohort included 2,076 patients. Data on comorbidities were available for 1,877/2,076 patients (90.4%). A total of 449/1,877 (23.9%) patients had at least 1 comorbidity at MS diagnosis. Age at diagnosis (odds ratio 1.05, 95% confidence interval [CI] 1.04–1.06; p < 0.001) was the only baseline factor independently related to the presence of comorbidities. Comorbidities were not significantly associated with the choice of the first disease-modifying treatment, but were significantly associated with higher risk to switch from the first treatment due to intolerance (hazard ratio 1.42, CI 1.07–1.87; p = 0.014). Association of comorbidities with risk of switching for intolerance was significantly heterogeneous among treatments (interferon β, glatiramer acetate, natalizumab, or fingolimod; interaction test, p = 0.04).

Conclusions: Comorbidities at diagnosis should be taken into account at the first treatment choice because they are associated with lower persistence on treatment.

GLOSSARY

CI=
confidence interval;
DMD=
disease-modifying drug;
EDSS=
Expanded Disability Status Scale;
GA=
glatiramer acetate;
HR=
hazard ratio;
IFN-β=
interferon β;
MS=
multiple sclerosis;
PML=
progressive multifocal leukoencephalopathy

Footnotes

  • Author affiliations are provided at the end of the article.

  • Coinvestigators are listed at Neurology.org.

  • Go to Neurology.org for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Supplemental data at Neurology.org

  • Editorial, page 2218

  • Received January 28, 2017.
  • Accepted in final form August 24, 2017.
  • © 2017 American Academy of Neurology
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