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November 28, 2017; 89 (22) ArticleOpen Access

Early weight loss in parkinsonism predicts poor outcomes

Evidence from an incident cohort study

Kirsten Cumming, Angus D. Macleod, Phyo K. Myint, Carl E. Counsell
First published October 27, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004691
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Article Information

vol. 89 no. 22 2254-2261
DOI: 
https://doi.org/10.1212/WNL.0000000000004691
PubMed: 
29079685
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received May 13, 2017
  • Accepted in final form September 11, 2017
  • First Published October 27, 2017.

Article Versions

Copyright & Usage: 
Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Disclosures

    1. Kirsten Cumming, MBChB*,
    2. Angus D. Macleod, PhD*,
    3. Phyo K. Myint, MD and
    4. Carl E. Counsell, MD
  1. Kirsten Cumming, MBChB*,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Angus D. Macleod, PhD*,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Chief Scientist Office of the Scottish Government, CAF 12/05, Clinical Academic Fellowship, 2012-2015 (2) Chief Scientist Office of the Scottish Government, PCL/17/10, NES/CSO Postdoctoral Clinical Lecturer Scheme, 2017-2019

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Parkinson's UK (G-1302) (2) Wellcome Trust (3) NHS Grampian Endowments (4) Academy of Medical Sciences

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Phyo K. Myint, MD and
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. ? Senior Editorial Board Member: American Journal of Cardiovascular Disease (April 2012-) ? Associate Editor: BMC Health Services Research Journal (2009-) ? International Editorial Board Member: Open Heart Failure Journal (2008- ) ? Editorial Board Member: Geriatrics (2014- ) ? Editorial Board Member: Annals of Translational Medicine (2016- ) ? Editorial Board Member: Scientific Reports (2017- ) ? Associate Editor: Frontiers in Neurology (2017- )

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. received funding support from NIHR (1)Research for Patient Benefit Programme; PB-PG-0212- 27075, Co-PI, 2016-2018 (2) Research for Patient Benefit Programme; PB-PG-0909- 20246, Co-PI, 2013-2017 (3) Programme Grant for Applied Research; RP-PG-0613- 20007, co-applicant, 2015-2020.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Carl E. Counsell, MD
    5. Scientific Advisory Boards:

    1. Served on Steering committee or Data Monitoring Committee for the following non-industry sponsored studies: PDMED (2004 ongoing); PDSURG (2002- 2010); PDCOMM (2016 ongoing). No financial compensation received for any of these except travel expenses.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Honorarium for speaking at Edinburgh Advanced Neurology Course, 2012 (bank transfer)

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. Employed by University of Aberdeen, UK

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Chief Scientist Office/Scottish Government, CZG/2/419, principal investigator, 2009-2011 (2) National Institute of Health Research/UK, RP-PG-0707- 10124, co-investigator, 2009-2014

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) Multiple Sclerosis Society, UK

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the School of Medicine (K.C.), Medical Sciences & Nutrition, and Chronic Disease Research Group (A.D.M., C.E.C.) and Ageing Clinical & Experimental Research Team (P.K.M.), Institute of Applied Health Sciences, University of Aberdeen, Scotland.
  1. Correspondence to Dr. Macleod: Angus.Macleod{at}abdn.ac.uk
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