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August 01, 2017; 89 (5) ArticleOpen Access

Mucuna pruriens in Parkinson disease

A double-blind, randomized, controlled, crossover study

Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Nicolò G. Pozzi, Ioannis U. Isaias, Manuela Contin, Michela Barichella, Gianni Pezzoli
First published July 5, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004175
Roberto Cilia
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Janeth Laguna
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Erica Cassani
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Emanuele Cereda
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Nicolò G. Pozzi
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Ioannis U. Isaias
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Manuela Contin
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Michela Barichella
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Gianni Pezzoli
From the Parkinson Institute (R.C., E. Cassani, M.B., G.P.), ASST Gaetano Pini-CTO, Milan, Italy; Neurology Clinic (J.L.), Clinica Niño Jesus, Santa Cruz, Bolivia; Nutrition and Dietetics Service (E. Cereda), Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Pathophysiology and Transplantation (N.G.P., I.U.I.), LAMB Pierfranco & Luisa Mariani, University of Milan, Italy; Department of Neurology (N.G.P., I.U.I.), University Hospital Würzburg and Julius-Maximilians-University, Würzburg, Germany; IRCCS–Institute of Neurological Sciences of Bologna (M.C.); and Department of Biomedical and Neuromotor Sciences (M.C.), University of Bologna, Italy.
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Full PDF
Citation
Mucuna pruriens in Parkinson disease
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Nicolò G. Pozzi, Ioannis U. Isaias, Manuela Contin, Michela Barichella, Gianni Pezzoli
Neurology Aug 2017, 89 (5) 432-438; DOI: 10.1212/WNL.0000000000004175

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    Figure 1 Changes (mean ± standard error) in Unified Parkinson’s Disease Rating Scale part III (motor score) at 90 and 180 minutes after treatment intake

    DDCI = dopa-decarboxylase inhibitor.

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