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August 01, 2017; 89 (5) Article

Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults

Kate E. Sprecher, Rebecca L. Koscik, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Ozioma C. Okonkwo, Mark A. Sager, Sanjay Asthana, Sterling C. Johnson, Ruth M. Benca, Barbara B. Bendlin
First published July 5, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004171
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Article Information

vol. 89 no. 5 445-453
DOI: 
https://doi.org/10.1212/WNL.0000000000004171
PubMed: 
28679595
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 28, 2016
  • Accepted in final form April 14, 2017
  • First Published July 5, 2017.

Article Versions

Copyright & Usage: 
© 2017 American Academy of Neurology

Author Disclosures

    1. Kate E. Sprecher, MS,
    2. Rebecca L. Koscik, PhD,
    3. Cynthia M. Carlsson, MD,
    4. Henrik Zetterberg, PhD, MD,
    5. Kaj Blennow, PhD, MD,
    6. Ozioma C. Okonkwo, PhD,
    7. Mark A. Sager, MD,
    8. Sanjay Asthana, MD,
    9. Sterling C. Johnson, PhD,
    10. Ruth M. Benca, MD, PhD and
    11. Barbara B. Bendlin, PhD
  1. Kate E. Sprecher, MS,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) National Institute on Aging, National Research Service Award F31 AG048732, PI, 2015-2017

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Rebecca L. Koscik, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Sponsor: NIH Grant Number: R01 AG027161 Role: Collaborator Years: 4/1/13 to 3/31/18

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Cynthia M. Carlsson, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. I receive research funding from the VA (I01 CX001261), NIH (AG033514), and serve as site PI for the A4 study (funded jointly by NIH and Lilly)

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. I am employed by the Madison VA Hospital. I receive research funding from the VA (I01 CX001261), NIH (AG033514), and serve as site PI for the A4 study (funded jointly by NIH and Lilly)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Henrik Zetterberg, PhD, MD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Alzheimer's Disease, Associate Editor Alzheimer's & Dementia, Associate Editor DADM, Associate Senior Editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. HZ is co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform company at the University of Gothenburg.

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) The Swedish Research Council (K2010-63P-21562-01-4, K2011-61X-20401-05-6); (2) Swedish State Support for Clinical Research (ALFGBG-144341); (3) VINNOVA; (4) the Knut and Alice Wallenberg Foundation; (5) the European Research Council; and (6) Frimurarestiftelsen

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Kaj Blennow, PhD, MD,
    6. Scientific Advisory Boards:

    1. Dr Blennow has served at advisory boards or as a consultant for Alzheon, Eli Lilly, Fujirebio Europe, IBL International, and Roche Diagnostics.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Novartis

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform company at the University of Gothenburg

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. The Research Council, Sweden (project # 14002) and LUA/ALF project, V?stra G?talandsregionen, Sweden (project # ALFGBG-11019)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. The Torsten S?derberg Foundation at the royal Swedish Academy of Sciences, the Alzheimer Foundation, Sweden, the Stiftelsen f?r Gamla Tj?narinnor, Stockholm, Sweden and Hj?rnfonden, Sweden.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Ozioma C. Okonkwo, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Associate Editor, Journal of Alzheimer's Disease 2017-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. NIH, P50 AG033514-S1, PI, 14 months. 2. NIH, K23 AG045957, PI, 12 months. 3. NIH R21AG051858

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Alzheimer's Association, NIRGD 305257 Extendicare Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Mark A. Sager, MD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIA RO1 AG 027161, PI, 2007-2011

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Sanjay Asthana, MD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1) Review Editor - Frontiers of Neuroscience; 2009 - Present 2) Associate Editor - Text book, entitled Hazzard's Geriatrics and Gerontology

    Patents:

    1. NONE

    Publishing Royalties:

    1. Associate Editor - Text book, entitled Hazzard's Geriatric Medicine and Gerontology

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Received research grant support as a site PI from the following companies to conduct clinical trials in patients with Alzheimer's disease (1) Wyeth Pharmaceutical, (2) Elan Pharmaceutical, (3) Eli Lilly, (4) Pfizer Pharmaceutical, 5) Merck, 6) Lundbeck, 7) Toyoma Chemicals

    Research Support, Government Entities:

    1. (1) NIH/NIA 1P50 AG033514-01, PI, 5/01/09-3/31/2014; (2) NIH/NIA 1RO1 AG029624-01, PI, 4/15/07-3/31/2012; (3) NIH/NIA 5KO7 AG021582, PI, 4/15/06-1/31/2011; (4) NIH/NIA 2T32 AG00213-17, PI, 7/1/1991-4/30/2012; (5) NIH/NIA 1RO1 AG027161, Co-I, 4/15/07-3/31/2012; (6) NIH/NIA UO1 AG- 10483 Alzheimer?s Disease Cooperative Study, UW Site PI, 10/1/09-6/30/2012; (7) NIH/NIA UO1 Alzheimer?s Disease Cooperative Study, UW Site PI, 7/1/08-6/30/2011; (8) NIH/NIA UO1 127-01-ADNI-024, UW Site Co-I, 6/1/05- Ongoing; (9) NIH/NIA, NACC Subcontract 5 UO1 AG016976, PI, 7/1/2010-3/31/2014; (10) Department of Veterans Affairs (VA), Office of Academic Affiliations, PI, 12/1/06-open; (11) Department of Veterans Affairs (VA), Cooperative Study Program (CSP), Site PI and Member of the Study Executive Committee, 7/1/07-open; (12) State of Wisconsin, PI, 7/1/05-Recurring; (13) ADCS/NIA studies as a site PI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. John A. Hartford Foundation Role: (PI) Period of Funding: 1/1/08-Present

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. Sterling C. Johnson, PhD,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1. Neuropsychology, editorial board member, 2009 to present 2. Journal of the International Neuropsychological Society, editorial board member, 2011 to present 3. Brain Imaging and Behavior, Associate editor

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NIH Study Panel member for >10 review sessions of the past two years

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. NIH R01AG021155, PI, 04-21 2. NIH P50 AG033514, core Leader, 09-19 3. NIH R01AG031790, Coinvestigator, 3 years 4. NIH R01 AG027161, PI, 2014-2018

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  10. Ruth M. Benca, MD, PhD and
    11. Scientific Advisory Boards:

    1. (1) Merck

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Sleep, Deputy Editor through December 2006-2016 (2) UpToDate, Section Editor, 2011-present (3) Editor-in-chief, Current Sleep Medicine Reports, 2014-present

    Patents:

    1. NONE

    Publishing Royalties:

    1. Sleep Disorders: The Clinician's Guide to Diagnosis and Management, Oxford University Press, 2011.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Janssen

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Barbara B. Bendlin, PhD
    12. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Alzheimer's Disease; Associate Editor; term ending 12/31/2018

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) NIH/NIA, Alzheimer's Disease Connectome Project, U01AG051216, 04/01/2016 - 03/31/2020, role: PI 2) NIH/NIA, ADRC Project 2: Midlife Insulin Resistance and obesity: Risk factors for AD-related brain change P50 AG033514 Project, 4/1/2014?3/31/2019, role: PI 3) NIH/NIA, White matter degeneration: biomarkers in preclinical Alzheimer's disease, R01AG037639, 4/1/2012 ? 3/31/2017, role: PI 4) NIH/NIA, Apnea and local sleep: Mechanism and intervention in preclinical Alzheimer's, R56AG052698, 09/30/2016 - 08/31/2017, Role: PI 5) NIH/NIA Diet and Exercise Trial to Improve Insulin Resistance, R21AG053738, 6/1/14 ? 5/31/16, Role: PI 6) NIH/NIA, Wisconsin Alzheimer?s Disease Research Center: NeuroImaging Core, P50 AG033514, 5/1/14 ? 3/31/19 Role: Co-Investigator 7) NIH, Center for Predictive Computational Phenotyping NIH 1U54AI117924, 9/1/14?8/31/19, Role: Project Collaborator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Medicine and Neuroscience Training Program (K.E.S.) and Wisconsin Alzheimer's Disease Research Center (C.M.C., O.C.O., M.A.S., S.A., S.C.J., B.B.B.), University of Wisconsin-Madison; Wisconsin Alzheimer's Institute (R.L.K., C.M.C., O.C.O., M.A.S., S.A., S.C.J., B.B.B.); Geriatric Research Education and Clinical Center (C.M.C., O.C.O., S.A., S.C.J., B.B.B.), Wm. S. Middleton Veterans Hospital, Madison, WI; Institute of Neuroscience and Physiology (H.Z., K.B.), University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; and Department of Psychiatry and Human Behavior (R.M.B.), University of California, Irvine.
  1. Correspondence to K.E. Sprecher: ksprecher{at}wisc.edu
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