Wrist sensor reveals sympathetic hyperactivity and hypoventilation before probable SUDEP
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Article Information
- Received December 11, 2016
- Accepted in final form May 1, 2017
- First Published July 12, 2017.
Article Versions
- Previous version (July 12, 2017 - 13:03).
- You are viewing the most recent version of this article.
Author Disclosures
- Rosalind W. Picard, ScD,
- Matteo Migliorini, PhD,
- Chiara Caborni, MSc,
- Francesco Onorati, PhD,
- Giulia Regalia, PhD,
- Daniel Friedman, MD and
- Orrin Devinsky, MD
- Rosalind W. Picard, ScD,
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Speaker travel expenses and/or honorarium from: ACM IUI, Seoul Digital Forum Korea, Trinity Institute, Society for Ambulatory Assessment, EmTech, CogSci, International Symposium on Pervasive Computing Paradigms for Mental Health, Scripps Mhealth, IEEE BCTM, Current Trends in Autism, University of PA, IEEE HCI, Veritas Forum (Georgia Tech, Harvard Medical School), Continuum, NIH, NIMH, Profectum, ETH Zurich, University of Bern, Florida International University, Lennox- Gastaut Society Foundation, XTech, NeuroTech, Body Sensor Networks, FDA OSEL, Santa Fe Institute, University of Florida, IEEE ISWC, ACM UBICOMP, Roanoke College, University of Notre Dame, Brown University, American Neuromodulation Society, USGov MITRE, ACM AAAI, Imperial College London, Deloitte, and Wharton/U Penn.
IEEE Journal Biomedical and Health Informatics, Guest Editor Special Issue, 2014-2015
(1) Patents related to the sensing of affective physiological data and to how autonomic data can characterize peri-ictal events
(1) Affective Computing, MIT Press, 1997-present
(1) MIT Media Lab, Professor, since 1991 (2) Empatica, Chief Scientist and Chairman, since 2014
(1) Empatica (2) Consultant for Apple & Intel as expert witness (see list below)
(1) SternStrategy
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(1) Media Lab Member Consortium at MIT (2) MedImmune (3) Takeda/Millennium (4) Deloitte (5) Steelcase (6) NEC (7) Cisco (8) LKK (9) Bose
(1) NIH (R01GM105018) PI on Subcontract, 2013-2018
(1) Mass General Hospital/MIT Challenge Award (2) University of Cambridge RG-70353 Marie Curie Award (3) University of Passau
(1) Simons Foundation Autism Research Initiative (2) Robert Wood Johnson Foundation
Empatica Board of Directors, Travel expenses
(1) Affective computing technology patents owned by MIT, payment of sublicense fees by Affectiva
(1) MIT Case no 12957T entitled Wearable Physiological Sensing System with Wireless Communication, 2011- (2) MIT Case no 13335T entitled Apparatus for Real-time and Offline Measurement, Quantifying, Tagging, and Prediction of Person(s) Experiences, 2011- (3) MIT Case no 14177TK entitled An Automated Method for Simultaneous Measurement of Multi-User Physiological Parameters from Digital Color Video, 2011- (4) MIT Case no 13146T entitled A Multi-Modal Affective- Cognitive Technique for Product Evaluation with Computational Models for Predicting Customer Decision, 2011-
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(1) Affectiva, 2009-present (2) Empatica, 2013-present
Intel, consultant and expert witness Apple, consultant and expert witness
- Matteo Migliorini, PhD,
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empatica inc, data scientist, 2
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Empatica Inc
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- Chiara Caborni, MSc,
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Empatica Inc., data scientist, 2
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Empatica Inc., 1
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- Francesco Onorati, PhD,
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(1) Empatica, Data Scientist, 2014-till now
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(1) Empatica, 2015-till now
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- Giulia Regalia, PhD,
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(1) Empatica Inc, data scientist, 2015-now
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(1) Empatica Inc, 2015-till now
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- Daniel Friedman, MD and
1) Marmo Health, scientific advisory board 2) Supernus, advisory board
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1) Neuropace, speaker honorarium 2) Liva Nova, speaker honorarium
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1) Minimally invasive long term seizure monitor
Dr. Friedman receives royalties from the sale of What Do I Do Now: Epilepsy (Oxford University Press, 2011)
Dr. Friedman receives salary support from The Epilepsy Study Consortium, a non-profit organization dedicated to improving the lives of epilepsy patients, and devotes 18% of his time to work done for the Consortium, supported by payments made by the Consortium to NYU. The Consortium receives payments from a large number of pharmaceutical companies for consulting activities. All payments are made to The Consortium and not to Dr. Friedman directly. Within the past year, the Epilepsy Study Consortium received payments from the companies listed below. All payments are reported annually and reviewed by NYU?s Conflict of Interest Committee. Accorda Pharmaceuticals, Alezxa Pharmaceuticals, GW Pharmaceuticals Eisai Medical Research, Pfizer, SK Life Science, Pfizer, Upsher Smith and Zynerba.
1) Cyberonics 2) UCB, Inc 3) GW Pharmaceuticals
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UCB Biosciences Inc
1) NINDS, Site-PI; R01 NS084142 2013-2018 2) NINDS, Site-PI; U01 NS090407 2014-2019 3) NINDS, Co-I; U01 NS090415 2014-2019 4) CDC, Co-I; SIP U48DP005008 2014-2019 5) NIMH, Co-I ; R01MH107396 2015-2020
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Epilepsy Foundation, FACES (finding a cure for epilepsy and seizures).
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- Orrin Devinsky, MD
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Cognitive and Behavioral Neurology; Oxford University Press, 2002 Epilepsy: Patient and Family Guide, Demos Press, 2008 Alternative Therapies for Epilepsy, Demos Press, 2012 Epilepsy In Children, Demos Press, 2015
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Scientific Advisory Board for Pairnomix, Egg Rock, and Tilray. Principal Investigator, North American SUDEP Registry and Sudden Unexplained Childhood Death Registry and Research Collaborative
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Ongoing Support NIH U01 NS090407 (PI: S. Lhatoo) 09/30/14 ? 7/31/2019 Center for SUDEP Research: Autonomic and Imaging Biomarkers of SUDEP The principal aim is to identify the central mechanisms and markers of autonomic and respiratory dysfunction that underlie the fatal scenario in SUDEP, and thus, provide insights into potential interventions. Role: Co-Investigator NIH U01 NS090415 (PIs: M. Thom, O. Devinsky) 9/30/14 ? 7/31/2019 Center for SUDEP Research: The Neuropathology of SUDEP: The central autonomic network, serotonin and adenosine The proposed studies will leverage the world?s largest collection of SUDEP brains to explore the role of specific histopathological and biomolecular abnormalities in the brain, focusing on critical brainstem regions and the neurotransmitters serotonin and adenosine. Role: PI National Center for Chronic Disease Prevention and Promotion U48 DP 005008-01S4 (PIs: T. Spruill, O. Devinsky) 9/1/2014 ? 8/31/2019 Managing Epilepsy Well: Adapting Project UPLIFT for Hispanic Adults with Epilepsy This project proposes to translate and culturally tailor Project UPLIFT for Hispanic patients, then test and disseminate the Spanish version. Project UPLIFT is an evidence-based intervention that incorporates cognitive behavioral and mindfulness techniques to reduce depression in adults with epilepsy. Role: Co-Investigator NIH R01 EB 018308 (PIs: K.T. Block, H. Chandarana) 9/1/2014 - 8/31/2019 Comprehensive Motion-Robust Pediatric MR Imaging Using Radial Acquisitions The proposed project aims to develop novel motion-robust magnetic resonance imaging techniques and evaluate them in clinical studies for imaging of pediatric patients with Tuberous Sclerosis. Role: Co-Investigator
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Pairnomix - Stock Tilray - Stock Egg Rock - Stock
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- From Massachusetts Institute of Technology (R.W.P.); Empatica, Inc. (R.W.P., M.M., C.C., F.O., G.R.), Cambridge, MA; and NYU Langone School of Medicine (D.F., O.D.), New York, NY.
- Correspondence to Dr. Picard: picard{at}media.mit.edu
Article usage
Cited By...
Letters: Rapid online correspondence
- Author response to Dr. Stewart
- Rosalind W. Picard, Professor, Massachusetts Institute of Technologypicard@media.mit.edu
- M Migliorini, C Caborni, F Onorati, G Regalia, D Friedman, O Devinsky
Submitted January 03, 2018 - Precipitous increase in sympathetic activity is consistent with airway obstruction
- Mark Stewart, Professor, Dean, SUNY Downstate Medical Centermark.stewart@downstate.edu
Submitted September 07, 2017
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