Precision therapy for epilepsy due to KCNT1 mutations
A randomized trial of oral quinidine
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Article Information
- Received May 21, 2017
- Accepted in final form September 15, 2017
- First Published December 1, 2017.
Article Versions
- Previous version (December 1, 2017 - 12:40).
- You are viewing the most recent version of this article.
Author Disclosures
- Saul A. Mullen, MBBS, PhD,
- Patrick W. Carney, MBBS, PhD,
- Annie Roten, BAppSc,
- Michael Ching, MPharm, PhD,
- Paul A. Lightfoot, BSc,
- Leonid Churilov, PhD,
- Umesh Nair, BSc,
- Melody Li, PhD,
- Samuel F. Berkovic, MBBS, MD,
- Steven Petrou, PhD and
- Ingrid E. Scheffer, MBBS, PhD
- Saul A. Mullen, MBBS, PhD,
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Florey Institute of Neuroscience and Mental Health, University of Melbourne, Australia Austin Health, Melbourne, Australia Eastern Health, Melbourne, Australia
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NHMRC Early Career Fellowship (1072081) NHMRC Project Grant (1062538)
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- Patrick W. Carney, MBBS, PhD,
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- Annie Roten, BAppSc,
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- Michael Ching, MPharm, PhD,
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- Paul A. Lightfoot, BSc,
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- Leonid Churilov, PhD,
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(1) Journal of Decision Systems, editorial board member, 2006-current (2) International Journal of Stroke, editorial board member, 2008-current (3) Operations Research for Health Care, editorial board member, 2011-current (4) Health Systems, editorial board member, 2012-current (5) Health Care Management Science, editorial board member, 2012-current
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Discrete-event simulation and system dynamics for management decision making, Wiley, 2015
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(1) Australian National Health and Medical Research Council; APP1113352; Associate Investigator; 2017-2022; (2) Australian National Health and Medical Research Council; APP1134495; Chief Investigator I; 2017-2021; (3) Australian National Health and Medical Research Council; APP1126070; Chief Investigator D; 2017-2020; (4) Australian National Health and Medical Research Council; APP1079179; Associate Investigator; 2015-2020; (5) Australian National Health and Medical Research Council; APP1094974; Chief Investigator I; 2015-2020; (6) Australian National Health and Medical Research Council; APP1081718; Associate Investigator; 2015-2018
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Diabetes Australia; MS Research Australia; National Stroke Foundation Australia
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- Umesh Nair, BSc,
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- Melody Li, PhD,
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- Samuel F. Berkovic, MBBS, MD,
UCB Pharma Eisai, Australia
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Brain (Editorial Board ? 2000 - 2004; Advisory Board 2005-2016 ) Epileptic Disorders (1999- ) Lancet Neurology (2011- )
I am one of the inventors listed on a patent held by Bionomics Inc on diagnostic testing of using the SCN1A gene. International publication number WO2006/133508; filed 16/06/2006. I am one of the inventors on pending patent WO61/010176: Therapeutic Compound that relates to discovery of PCDH19 gene as the cause of familial epilepsy with mental retardation limited to females
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UCB unrestricted research grant SciGen unrestricted research grant Eisai unrestricted research grant
National Health and Medical Research Council of Australia (Program Grant #1091593; 2016-2020) NINDS (U01 NS077367-01; 2011-2014)
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- Steven Petrou, PhD and
Pairnomix RogCon Praxis Precision Medicines
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PLOS Genetics Associate Editor, 2013-Present Neurobiology of Disease, Editorial Board Member, 2008-Present
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RogCon. $1.5M
2016 Ion Channel Drug Screening. TIA NCRIS. Petrou and Milligan. $39,000 Chief Investigator 2016-2018 ARC DP160104193. Clarity and MRI. Connelly and Petrou. $455,700 Chief Investigator 2016-2018 NHMRC Project APP1106027. Modelling epileptic encephalopathies using induced stem cells. Petrou and Pera $506,489 Chief Investigator 2016-2020 NHMRC Principal Research Fellowship. Targeted therapy in genetic epilepsy. Petrou. $753,300. Chief Investigator 2016-2021 NHMRC Program Grant Precision Medicine in Genetic Epilepsy. $15,000,000 Chief Investigator 2014-2021 ARC Centre of Excellence for Integrative Brain Function (CIBF). $12,000,000 Chief Investigator
The University of Melbourne, $2.5M
2016 DHB foundation. Glass brain imaging: Building a roadmap to the brain. Petrou S. $300K 2016 SCN2A Research Foundation, $500K
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- Ingrid E. Scheffer, MBBS, PhD
(1) Ramaciotti foundation - Scientific Advisory Committee 2014, 2015
2014 Prime Ministers Prize For Science
Travel (1) Zogenix: USA 2016 (2) Sanofi: China 2015 (3) UCB; Japan 2015 (4) GSK; Japan 2015 Honoraria (1) Eisai: 2015 (2) Sanofi 2015 (3) UCB: 2015, 2014 (4) GSK; Japan 2015
(1) Neurology, Editorial Board, 2014-present (2) Epilepsy Currents, Editorial Board, 2014-present (3) Annals of Neurology, Editorial Board, 2007-2015 (4) Epileptic Disorders, Editorial Board, 2006-present (5) Progress in Epileptic Disorders series, Editorial Board, 2005-present (6) Virtual Neuro Centre, Editorial Board, 2005-present
Has received revenue for: (1) Diagnostic and therapeutic methods for EFMR (2) A Diagnostic Method for Epilepsy Issued
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(1) NHMRC Program Grant 2016-2020 (2) NHMRC Practitioner Fellowship 2016- 2020 (3) NHMRC Project Grant 2016-2020
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(1) Epilepsy Association of Tasmania 2013-2015 (2) Melbourne Neurosciences Institute 2014 (3) Weizmann Institute 2013-2014 (4) March of Dimes 2015-2016 (5) Rebecca L Cooper Medical Research Foundation 2016 (6) Health Research Council New Zealand 2015-2018 (7) March Of Dimes Foundation 2015-2017
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Diagnostic and Therapeutic Methods for EFMR (Epilepsy and Mental Retardation Limited to Females)
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- From The Florey Institute of Neuroscience and Mental Health (S.A.M., P.W.C., L.C., U.N., M.L., S.P.), Epilepsy Research Centre, Department of Medicine (S.A.M., A.R., P.A.L., S.F.B., I.E.S.), and Department of Paediatrics, Royal Children's Hospital (I.E.S.), University of Melbourne; Department of Medicine (S.A.M., A.R., P.A.L., S.F.B., I.E.S.), and Department of Pharmacy (M.C.), Austin Health; and Department of Medicine (P.W.C.), Monash University and Eastern Health, Melbourne, Australia.
- Correspondence
Dr. Scheffer scheffer{at}unimelb.edu.au
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