Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
    • Education
  • Online Sections
    • Neurology Video Journal Club
    • Inclusion, Diversity, Equity, Anti-racism, & Social Justice (IDEAS)
    • Innovations in Care Delivery
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

April 03, 2018; 90 (14) In Focus

Spotlight on the April 3 issue

Robert A. Gross
First published April 2, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005244
Robert A. Gross
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Spotlight on the April 3 issue
Robert A. Gross
Neurology Apr 2018, 90 (14) 629-630; DOI: 10.1212/WNL.0000000000005244

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
207

Share

  • Article
  • Info & Disclosures
Loading

Notable in Neurology this week

This issue features an article that explains the clinical value of the central vein sign on a clinical 3T scanner for the differential diagnosis of multiple sclerosis and neuromyelitis optica spectrum disorder; another details the suitability of atrophy, demyelination, and iron accumulation as markers of therapeutic intervention following spinal cord injury. A featured Special Article outlines the American Academy of Neurology Institute and Society for Neuro-Oncology approved quality measurement set for neuro-oncology.

Articles

Sun exposure over the life course and associations with multiple sclerosis

Sunlight exposure may alter multiple sclerosis (MS) risk; however, its measurement and timing are not well-delineated. The authors reviewed sun exposure in patients with MS and age-matched controls, and found that living in high (vs low) ultraviolet B areas prior to MS onset was associated with a lower MS risk.

Page 638

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

As cannabidiol use increases among patients with epilepsy, pharmacokinetic data are needed. In this study of children with Dravet syndrome, cannabidiol levels and levels of its metabolites increased proportionally with dose. The only antiepileptic drug interaction was an increase in the nordesmethyl metabolite of clobazam. These findings emphasize a need for more cannabidiol data.

Page 640

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

In this article, the authors elucidate a potential new therapy for an underdiagnosed and disabling genetic condition: primary mitochondrial myopathy (PMM). Elamipretide, studied in PMM, improved exercise performance following 5 days of IV treatment without safety concerns. Elamipretide's therapeutic benefits support initiation of a phase 3 program in patients with PMM.

Embedded Image

Page 641

From editorialists Vissing and Angelini: “Remodeling the mitochondrial inner membrane with elamipretide is an interesting new treatment strategy for mitochondrial myopathies, which although not curative, could prove an important treatment option for this patient group, not only as monotherapy, but potentially also in combination with aerobic training or other noncurative therapies.”

Page 633

Arterial stiffness and dementia pathology: Atherosclerosis Risk in Communities (ARIC)-PET Study

Arterial stiffness is underappreciated as a biomarker of dementia risk. The authors show, in a cross-sectional study, that greater arterial stiffness is associated with evidence of dementia pathology seen on MRI and PET. The effects of hemodynamic abnormalities in the pathologic progression of dementia are just beginning to emerge.

Page 645

From editorialists Lopez and Maillard: “These findings confirmed previous observations on the relationship between arterial stiffness and Aβ amyloid deposition, and consolidated the notion that there is an association between systemic vascular disease and Aβ amyloid deposition.”

Page 635

Embedded Image

  • NB: “International Issues: A guide to US academic global health programs in neurology,” p. 662. To check out other Resident & Fellow International Issues articles, point your browser to Neurology.org/N and click on the link to the Resident & Fellow section. At the end of the issue, check out the Resident & Fellow Clinical Reasoning paper discussing the case of a middle-aged woman presenting with headache and an altered mental status. This week also includes a Video NeuroImage titled “Paraneoplastic spinal myoclonus associated with Caspr2 antibodies.”

  • Editor's Summary: NPub.org/edsum

  • © 2018 American Academy of Neurology

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

If you are uploading a letter concerning an article:
You must have updated your disclosures within six months: http://submit.neurology.org

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Articles
  • Info & Disclosures
Advertisement

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published
Neurology: 99 (6)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • Neurology: Education
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2022 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise