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April 10, 2018; 90 (15) Article

Psychiatric comorbidity is associated with disability progression in multiple sclerosis

Kyla A. McKay, Helen Tremlett, John D. Fisk, Tingting Zhang, Scott B. Patten, Lorne Kastrukoff, Trudy Campbell, Ruth Ann Marrie, For the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis
First published March 9, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005302
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Article Information

vol. 90 no. 15 e1316-e1323
DOI: 
https://doi.org/10.1212/WNL.0000000000005302
PubMed: 
29523642
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 29, 2017
  • Accepted in final form January 8, 2018
  • First Published March 9, 2018.

Article Versions

Copyright & Usage: 
© 2018 American Academy of Neurology

Author Disclosures

    1. Kyla A. McKay, PhD,
    2. Helen Tremlett, PhD,
    3. John D. Fisk, PhD,
    4. Tingting Zhang, PhD,
    5. Scott B. Patten, MD, PhD,
    6. Lorne Kastrukoff, MD,
    7. Trudy Campbell, RN,
    8. Ruth Ann Marrie, MD, PhD;
    9. For the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis
  1. Kyla A. McKay, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Canadian Institutes of Health Research Canada Frederick Banting and Charles Best Canada Graduate Scholarship Doctoral Award

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Helen Tremlett, PhD,
    3. Scientific Advisory Boards:

    1. All non-profit: ? National US surveillance system for MS. 2013-present. Invited by the US National MS Society to form an advisory group to enable the development of a national surveillance system capable of tracking the incidence and prevalence of MS. Monthly teleconferences; one face-to-face meeting: Atlanta, Georgia (March 2014) Status: Bipartisan legislation introduced to Congress - ?Advancing Research for Neurological Diseases Act, H.R. 292.?to guide the Centers for Disease Control and Prevention in tracking the incidence and prevalence of neurological diseases, including Multiple Sclerosis and Parkinson?s disease [13th-Jan-2015; http://burgess.house.gov/blog/? postid=397459]

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Helen Tremlett is the Canada Research Chair for Neuroepidemiology and Multiple Sclerosis. She currently receives research support from the National Multiple Sclerosis Society, the Canadian Institutes of Health Research, the Multiple Sclerosis Society of Canada and the Multiple Sclerosis Scientific Research Foundation. In addition, in the last five years she has received research support from the Multiple Sclerosis Society of Canada (Don Paty Career Development Award); the Michael Smith Foundation for Health Research (Scholar Award) and the UK MS Trust; speaker honoraria and/or travel expenses to attend conferences from the Consortium of MS Centres (2013), the National MS Society (2012, 2014, 2016), ECTRIMS (2012, 2013, 2014, 2015, 2016), the Chesapeake Health Education Program, US Veterans Affairs (2012), Novartis Canada (2012), Biogen Idec (2014), American Academy of Neurology (2013, 2014, 2015, 2016). All speaker honoraria are either declined or donated to an MS charity or to an unrestricted grant for use by her research group.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Canada Foundation for Innovation (CFI); Canadian Institutes of Health Research [#363635 (co-PI); #190898 (PI) and #MOP-82738 (PI) and MOP-119393 (PI) and MOP-106607 (PI)]; the US National Multiple Sclerosis Society (Operating grants: 2012-15; 2014-17), the Multiple Sclerosis Society of Canada (2015-18: EGID #2624 (PI); 2016-18: EGID #2680 (co-PI); ) the The Multiple Sclerosis Scientific and Research Foundation (2015-18 (PI)); Canada Research Chair in Neuroepidemiology and Multiple Sclerosis

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. John D. Fisk, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. EMD Serono, Travel expenses and $1500 honourarium for workshop participation (June 2014).

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1)CIHR operating grant, ?Early and preclinical diagnosis of Parkinson's disease using olfactory testing and Diffusion Tensor Imaging of olfactory bulb and substantia nigra.? 2012-2017, Co-investigator. (2)CIHR Team Grant, ?Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease.? 07/2014-06/2019,Co- investigator. (3)CIHR ? Emerging Team Grant: "Co-morbidity of brain disorders and other health problems" 2010?2015, Co- investigator. (4) CIHR operating grant, ?Epidemiology of cognitive dynamics in older adults? 2010 -2015, Co-investigator (5) CIHR catalyst grant (Exploring ADNI and other Neuroimaging Databases to benefit the early detection of Alzheimer's Disease and Related Dementias),?Alternative FDG-PET relative standardized uptake value metrics for the assessment of early metabolic biomarkers of Alzheimer's disease.? 2014-2016, Co-investigator. (6) CIHR catalyst grant (Exploring ADNI and other Neuroimaging Databases to benefit the early detection of Alzheimer's Disease and Related Dementias)?Pre- symptomatic biomarkers for Alzheimer?s disease: Structural and functional changes in white matter and brain connectivity.? 2014-2016, Co-investigator. (7)Nova Scotia Health Authority Research Fund, ?Cognitive dysfunction in SLE: a pilot neuroimaging study? 2016- 2017, Co-Investigator.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1)National MS Society operating Grant ?Prodromal Multiple Sclerosis: The PrOMS Study?. 2016 - 2018, Co- investigator. (2)MS Society of Canada (Clinical and Population Health Operating Grant EGID: 2639), ?Comorbidity, cognition and multiple sclerosis (C-CoMS)? 2016-2019, Co-Investigator. (3)MS Society of Canada (Clinical and Population Health Operating Grant) ?A double-blind placebo controlled study of mixed-amphetamine salts, extended release (Adderall XR) for cognitive impairment in MS? 2016-2018, Co- Investigator.

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License fee payments, Technology or Inventions:

    1. Fatigue Impact Scale and Daily Fatigue Impact Scale, Licensing and Distribution agreement with MAPI Research Trust.

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Tingting Zhang, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Multiple Sclerosis of Canada, Post-Doctoral Fellowship Award (2014/2015-2015/2016)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Scott B. Patten, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Canadian Journal of Psychiatry, Editor-in-Chief, 2014-present. (2) Health Promotion, Chronic Disease and Injury Prevention in Canada, Editorial Advisory Board Member, 2009-present. (3) Clinical Practice and Epidemiology in Mental Health, Editorial Advisory Board Member, 2010-present. (4) Sr. Assoc. Editor, Epidemiology & Psychiatric Sciences

    Patents:

    1. NONE

    Publishing Royalties:

    1. Epidemiology for Canadian Students. Brush Education, 2015.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Hotchkiss Brain Institute. Depression in the Community, 2013-2016. (2) Hotchkiss Brain Institute/Pfizer Research Competition. Building a Foundation for a Depression eHub for Neurological Patients, 2015 - 2016.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Lorne Kastrukoff, MD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Trudy Campbell, RN,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Commercial travel support and speaker honoraria from ROCHE, BIOGEN, TEVA Canada Innovation, EMD Serono, Sanofi- Genzyme.

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) Biogen Idec Canada (2) Genzyme Canada (3) Novartis Canada

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Ruth Ann Marrie, MD, PhD;
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurology, Editorial Board Multiple Sclerosis Journal, Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Received support as principal investigator from the Canadian Institutes of Health Research (2010-2019), and Research Manitoba (2014-2019).

    Research Support, Academic Entities:

    1. Waugh Family Chair in Multiple Sclerosis

    Research Support, Foundations and Societies:

    1. Received support as principal investigator from Multiple Sclerosis Society of Canada (2009-2016) and the National Multiple Sclerosis Society (2013-2017), and as co-principal investigator from Multiple Sclerosis Scientific Foundation (2009-2018). Received support from Consortium of Multiple Sclerosis Centers (2004-2009, 2011-2014, 2016-2017), Crohn's and Colitis Canada (2014- 2019)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. For the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis
    1. From the Department of Medicine (K.A.M., H.T., L.K.), Division of Neurology and Centre for Brain Health, University of British Columbia, Vancouver; Department of Medicine (J.D.F., T.C.) and School of Nursing, Faculty of Health Professions (T.C.), Dalhousie University, Halifax, Canada; Department of Health Services, Policy & Practice (T.Z.), Brown University School of Public Health, Providence, RI; Departments of Psychiatry and Community Health Sciences (S.B.P.), Cumming School of Medicine, University of Calgary; and Departments of Internal Medicine and Community Health Sciences (R.A.M.), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
    1. Correspondence
      Dr. Marrie rmarrie{at}hsc.mb.ca

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