Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

April 10, 2018; 90 (15 Supplement) April 26, 2018

The relationship between Mini-Mental State Examination (MMSE) & Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog) using real world data in US & Europe (P5.178)

Rezaul Khandker, Christopher Black, James Pike, Joseph Husbands, Baishali Ambegaonkar, Eddie Jones
First published April 9, 2018,
Rezaul Khandker
1Merck North Wales PA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher Black
1Merck North Wales PA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James Pike
2Adelphi Manchester United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph Husbands
2Adelphi Manchester United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Baishali Ambegaonkar
1Merck North Wales PA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eddie Jones
2Adelphi Manchester United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Citation
The relationship between Mini-Mental State Examination (MMSE) & Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog) using real world data in US & Europe (P5.178)
Rezaul Khandker, Christopher Black, James Pike, Joseph Husbands, Baishali Ambegaonkar, Eddie Jones
Neurology Apr 2018, 90 (15 Supplement) P5.178;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
0

Share

  • Article
  • Info & Disclosures
Loading

Abstract

Objective: To investigate the relationship between MMSE and ADAS-cog.

Background: There is a need to understand how the burden of cognitive impairment changes with severity. This will help target interventions to the most appropriate patients. Across western regions MMSE is the most widely used severity assessment in real world clinical practice, however many RCTs make use of the ADAS-cog. In order to understand the potential impact of new interventions in the real world we need to understand the comparability of these two severity assessments, before burden can be assessed.

Design/Methods: Data were drawn from the Adelphi ADAS-cog Study, a retrospective cross-sectional study of cognitively impaired patients in France, Germany, Italy, Spain, U.K., and the U.S. Patients with recently assessed ADAS-cog (most recent in last six months and second most recent in last 24 months), and recently assessed MMSE (within one month of ADAS-cog assessments) were identified. Generalized estimating equation regression with Gaussian errors, identity link, and exchangeable correlation was used to model the relationship between MMSE and ADAS-cog, with ADAS-cog as dependent variable and MMSE as independent variable. Analysis was repeated utilizing restricted cubic splines of MMSE, to allow for a non-linear relationship between ADAS-cog and MMSE. R-squared was calculated for recorded ADAS-cog and regression-predicted ADAS-cog.

Results: Analysis was conducted on 813 patients and 1520 paired MMSE/ADAS-cog assessments. There was a significant association between MMSE and ADAS-cog (p<0.001, R-squared =0.561). A decrease of one in MMSE was associated with an increase of 2.01 (95% CI [1.90, 2.11]) in ADAS-cog. Cubic spline terms for MMSE were not significant (p=0.298) indicating a linear relationship.

Conclusions: There is a strong association between the MMSE and ADAS-cog, indicating that where disease burden has been measured for one of these severity assessments, similar conclusions may be drawn for the other.

Disclosure: Dr. Khandker has nothing to disclose. Dr. Black has nothing to disclose. Dr. Pike has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Employees of Adelphi Real World and paid consultants for Biogen. Dr. Husbands has nothing to disclose. Dr. Ambegaonkar has nothing to disclose. Dr. Jones has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with employee of Adelphi Real World and paid consultants for Biogen.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Info & Disclosures
Advertisement

Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias

Dr. Sevil Yaşar and Dr. Behnam Sabayan

► Watch

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published
Neurology: 101 (13)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise