Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

April 10, 2018; 90 (15 Supplement) April 22, 2018

Automatic Detection of ON/OFF states in Parkinson Disease Patients Using Wearable Sensor Technology (S3.007)

Vibha Anand, Erhan Bilal, Vesper Ramos, Melissa Naylor, Charmaine Demauele, Hao Zhang, Stephen Amato, Paul Wacnik, Farhan Hameed, Tairmae Kangarloo, Bryan Ho, Kelley Erb, Daniel Karlin
First published April 9, 2018,
Vibha Anand
1IBM T.J. Watson Research Center Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Erhan Bilal
1IBM T.J. Watson Research Center Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vesper Ramos
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Melissa Naylor
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charmaine Demauele
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hao Zhang
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen Amato
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Wacnik
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Farhan Hameed
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tairmae Kangarloo
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bryan Ho
3Movement Disorders Program, Department of Neurology, Tufts Medical Center Boston MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kelley Erb
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Karlin
2Pfizer Inc., Early Clinical Development, Worldwide Research and Development Cambridge MA United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Citation
Automatic Detection of ON/OFF states in Parkinson Disease Patients Using Wearable Sensor Technology (S3.007)
Vibha Anand, Erhan Bilal, Vesper Ramos, Melissa Naylor, Charmaine Demauele, Hao Zhang, Stephen Amato, Paul Wacnik, Farhan Hameed, Tairmae Kangarloo, Bryan Ho, Kelley Erb, Daniel Karlin
Neurology Apr 2018, 90 (15 Supplement) S3.007;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
0

Share

  • Article
  • Info & Disclosures
Loading

Abstract

Objective: To detect self-reported ON and OFF states in Parkinson Disease (PD) patients from wearable sensor technology.

Background: Reliably detecting ON/OFF states is important for monitoring PD treatment and progression. Currently, subjective patient diaries capture this information. We investigate if detection of motor signs of ON/OFF states can be achieved by using kinematic measurements from wearable sensor technology combined with a machine learning (ML) pipeline.

Design/Methods: Twenty-five PD subjects (19 males, 69±7 years) taking levodopa performed 10-meter Instrumented Stand and Walk (ISAW) tests in their ON and OFF states while wearing Ambulatory Parkinson Disease Monitoring (APDM) sensors on their sternum, wrists, lumbar and lower extremities. A neurologist scored each ISAW according to the MDS-UPDRS-III. We analyzed 98 kinematic features for significance to neurologist total motor score and ON/OFF using both statistical (repeated-measures ANOVA, step-wise mixed-model regression, likelihood-ratio test, ridge regression) and ML methods.

Results: Twenty-two features significantly differed between patient reported ON/OFF states, with the most significant being trunk transverse range-of-motion (RofM), arm RofM, mid-swing elevation, stride length, turn velocity, steps in turn and toe out angles. Estimates from regression model showed average difference of 14 points between OFF/ON states in total UPDRS score and 9 points when adjusted for 5 significant features for individual baseline (mean trunk transverse RofM, right arm RofM, and toe out angle having highest effect; coeff. −8.67, −5.25, −3.36 respectively). Several approaches were employed for predicting ON/OFF states based on these features: direct binary classification (acc=0.56), regression to total UPDRS score (acc=0.76), regression to PIGD sub-score (acc=0.64), and classification of ON-OFF/OFF-ON transitions using feature differences (Naïve Bayes: acc=0.74, AUC=0.78; Random Forest: acc=0.76, AUC=0.90).

Conclusions: Wearable sensor technology holds promise for detecting ON/OFF states in PD patients using an augmented ML approach. This could be particularly useful for monitoring response to therapy in an outpatient setting.

Disclosure: Dr. Anand has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with IBM. Dr. Bilal has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with IBM. Dr. Ramos has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer, Inc. Dr. Naylor has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer, Inc. Dr. Demauele has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer Inc., Biogen. Dr. Zhang has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer Inc. Dr. Amato has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer, Inc. Dr. Wacnik has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer, inc. Dr. Hameed has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer, Inc. Dr. Kangarloo has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer Inc. Dr. Ho has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer, Inc. Dr. Erb has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer, Inc. Dr. Karlin has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Pfizer Inc.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
  • Info & Disclosures
Advertisement

Related Articles

  • No related articles found.

Alert Me

  • Alert me when eletters are published
Neurology: 96 (16)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise