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May 01, 2018; 90 (18) Article

Interfacility transfers for US ischemic stroke and TIA, 2006–2014

Benjamin P. George, Sara J. Doyle, George P. Albert, Ania Busza, Robert G. Holloway, Kevin N. Sheth, Adam G. Kelly
First published April 4, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005419
Benjamin P. George
From the Department of Neurology (B.P.G., A.B., R.G.H., A.G.K.), University of Rochester Medical Center, NY; Department of Neurology (S.J.D.), Northwestern University School of Medicine, Chicago, IL; College of Arts & Sciences (G.P.A.), University of Rochester, NY; and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (K.N.S.), Yale School of Medicine, New Haven, CT.
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Sara J. Doyle
From the Department of Neurology (B.P.G., A.B., R.G.H., A.G.K.), University of Rochester Medical Center, NY; Department of Neurology (S.J.D.), Northwestern University School of Medicine, Chicago, IL; College of Arts & Sciences (G.P.A.), University of Rochester, NY; and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (K.N.S.), Yale School of Medicine, New Haven, CT.
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George P. Albert
From the Department of Neurology (B.P.G., A.B., R.G.H., A.G.K.), University of Rochester Medical Center, NY; Department of Neurology (S.J.D.), Northwestern University School of Medicine, Chicago, IL; College of Arts & Sciences (G.P.A.), University of Rochester, NY; and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (K.N.S.), Yale School of Medicine, New Haven, CT.
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Ania Busza
From the Department of Neurology (B.P.G., A.B., R.G.H., A.G.K.), University of Rochester Medical Center, NY; Department of Neurology (S.J.D.), Northwestern University School of Medicine, Chicago, IL; College of Arts & Sciences (G.P.A.), University of Rochester, NY; and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (K.N.S.), Yale School of Medicine, New Haven, CT.
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Robert G. Holloway
From the Department of Neurology (B.P.G., A.B., R.G.H., A.G.K.), University of Rochester Medical Center, NY; Department of Neurology (S.J.D.), Northwestern University School of Medicine, Chicago, IL; College of Arts & Sciences (G.P.A.), University of Rochester, NY; and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (K.N.S.), Yale School of Medicine, New Haven, CT.
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Kevin N. Sheth
From the Department of Neurology (B.P.G., A.B., R.G.H., A.G.K.), University of Rochester Medical Center, NY; Department of Neurology (S.J.D.), Northwestern University School of Medicine, Chicago, IL; College of Arts & Sciences (G.P.A.), University of Rochester, NY; and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (K.N.S.), Yale School of Medicine, New Haven, CT.
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Adam G. Kelly
From the Department of Neurology (B.P.G., A.B., R.G.H., A.G.K.), University of Rochester Medical Center, NY; Department of Neurology (S.J.D.), Northwestern University School of Medicine, Chicago, IL; College of Arts & Sciences (G.P.A.), University of Rochester, NY; and Division of Neurocritical Care and Emergency Neurology, Department of Neurology (K.N.S.), Yale School of Medicine, New Haven, CT.
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Citation
Interfacility transfers for US ischemic stroke and TIA, 2006–2014
Benjamin P. George, Sara J. Doyle, George P. Albert, Ania Busza, Robert G. Holloway, Kevin N. Sheth, Adam G. Kelly
Neurology May 2018, 90 (18) e1561-e1569; DOI: 10.1212/WNL.0000000000005419

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Abstract

Objective To investigate changes in emergency department (ED) transfers for ischemic stroke (IS) and TIA.

Methods We performed a retrospective observational study using the US Nationwide Emergency Department Sample to identify changes in interfacility ED transfers for IS and TIA from the perspective of the transferring ED (2006–2014). We calculated nationwide transfer rates and individual ED transfer rates for IS/TIA by diagnosis and hospital characteristics. Hospital-level fractional logistic regression examined changes in transfer rates over time.

Results The population-estimated number of transfers for IS/TIA increased from 22,576 patient visits in 2006 to 54,485 patient visits in 2014 (p trend < 0.001). The rate of IS/TIA transfer increased from 3.4 (95% confidence interval [CI] 3.0–3.8) in 2006 to 7.6 (95% CI 7.2–7.9) in 2014 per 100 ED visits. Among individual EDs, mean transfer rates for IS/TIA increased from 8.2 per 100 ED visits (median 2.0, interquartile range [IQR] 0–10.2) to 19.4 per 100 ED visits (median 8.1, IQR 1.1–33.3) (2006–2014) (p trend < 0.001). Transfers were more common among IS. Transfer rates were greatest among rural (adjusted odds ratio [AOR] 3.05, 95% CI 2.56–3.64) vs urban/teaching and low-volume EDs (AOR 7.49, 95% CI 6.58–8.53, 1st vs 4th quartile). The adjusted odds of transfer for IS/TIA increased threefold (2006–2014).

Conclusions Interfacility ED transfers for IS/TIA more than doubled from 2006 to 2014. Further work should determine the necessity of IS/TIA transfers and seek to optimize the US stroke care system.

Glossary

AOR=
adjusted odds ratio;
CI=
confidence interval;
ED=
emergency department;
HCUP=
Healthcare Cost and Utilization Project;
ICD-9=
International Classification of Disease, 9th Revision;
IQR=
interquartile range;
IS=
ischemic stroke;
NEDS=
Nationwide Emergency Department Sample;
tPA=
tissue plasminogen activator

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • CME Course: NPub.org/cmelist

  • Editorial, page 821

  • Received September 25, 2017.
  • Accepted in final form January 8, 2018.
  • © 2018 American Academy of Neurology
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