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May 08, 2018; 90 (19) ArticleOpen Access

Prevalence of preclinical Alzheimer disease

Comparison of current classification systems

Silke Kern, Henrik Zetterberg, Jürgen Kern, Anna Zettergren, Margda Waern, Kina Höglund, Ulf Andreasson, Hanna Wetterberg, Anne Börjesson-Hanson, Kaj Blennow, Ingmar Skoog
First published April 13, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005476
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    Figure Venn diagram

    Venn diagram of the ATN distribution of amyloid and tau pathology according to the A/T/N classification scheme in a representative population-based sample of 70-year-olds with a Clinical Dementia Rating score of 0. A+ refers to Aβ pathology (CSF Aβ42 levels ≤530 pg/mL), T+ to pathologic p-tau (CSF p-tau ≥ 80 pg/mL), and N+ to neurodegeneration biomarker (CSF total tau ≥350 pg/mL) in 259 cognitively normal elderly all 70 years of age. Aβ = β-amyloid; p-tau = phosphorylated tau.

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