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Abstract
Objective To investigate the optimal combination of dietary polyphenols associated with the long-term risk of dementia in a large prospective French cohort of older persons, the Three-City (3C) Study.
Methods We included 1,329 older adults without dementia from the 3C study with assessment of intake of 26 polyphenol subclasses who were followed up for 12 years for dementia. Using partial least squares for Cox models, we identified a pattern of polyphenol intake associated with dementia risk.
Results The pattern combined several flavonoids (dihydroflavonols, anthocyanins, isoflavonoids, flavanones), stilbenes (including resveratrol), lignans, and other subclasses (hydroxybenzaldehydes, naphthoquinones, furanocoumarins). Compared with participants in the lower quintile of pattern score, those in the higher quintile had a 50% lower risk of dementia (95% confidence interval 20%–68%, p for trend <0.01) in multivariate models.
Conclusions In this French cohort, a polyphenol pattern provided by a diet containing specific plant products (nuts, citrus, berries, leafy vegetables, soy, cereals, olive oil) accompanied by red wine and tea was associated with lower dementia risk.
Glossary
- AD=
- Alzheimer disease;
- DSM-IV=
- Diagnostic and Statistical Manual of Mental Disorders, 4th edition;
- MIND=
- Mediterranean-Dietary Approach to Stop Hypertension Intervention for Neurodegenerative Delay;
- MMSE=
- Mini-Mental State Examination;
- PAQUID=
- Personnes Agées Quid;
- PLS-Cox=
- partial least squares regression for Cox model;
- SU.VI.MAX=
- Supplémentation en Vitamines et. Minéraux Antioxydants;
- 3C=
- Three-City
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
- Received October 16, 2017.
- Accepted in final form March 13, 2018.
- © 2018 American Academy of Neurology
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