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January 16, 2018; 90 (3) Article

Comparative effect of statins on the risk of incident Alzheimer disease

Liliya Sinyavskaya, Serge Gauthier, Christel Renoux, Sophie Dell'Aniello, Samy Suissa, Paul Brassard
First published December 15, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004818
Liliya Sinyavskaya
From the Centre for Clinical Epidemiology (L.S., C.R., S.D., S.S., P.B.), Jewish General Hospital; McGill University Research Centre for Studies in Aging (S.G.), Douglas Mental Health University Institute; and Departments of Neurology and Neurosurgery (C.R.) and Medicine and Epidemiology, Biostatistics, and Occupational Health (C.R., S.S., P.B.), McGill University, Montreal, Canada.
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Serge Gauthier
From the Centre for Clinical Epidemiology (L.S., C.R., S.D., S.S., P.B.), Jewish General Hospital; McGill University Research Centre for Studies in Aging (S.G.), Douglas Mental Health University Institute; and Departments of Neurology and Neurosurgery (C.R.) and Medicine and Epidemiology, Biostatistics, and Occupational Health (C.R., S.S., P.B.), McGill University, Montreal, Canada.
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Christel Renoux
From the Centre for Clinical Epidemiology (L.S., C.R., S.D., S.S., P.B.), Jewish General Hospital; McGill University Research Centre for Studies in Aging (S.G.), Douglas Mental Health University Institute; and Departments of Neurology and Neurosurgery (C.R.) and Medicine and Epidemiology, Biostatistics, and Occupational Health (C.R., S.S., P.B.), McGill University, Montreal, Canada.
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Sophie Dell'Aniello
From the Centre for Clinical Epidemiology (L.S., C.R., S.D., S.S., P.B.), Jewish General Hospital; McGill University Research Centre for Studies in Aging (S.G.), Douglas Mental Health University Institute; and Departments of Neurology and Neurosurgery (C.R.) and Medicine and Epidemiology, Biostatistics, and Occupational Health (C.R., S.S., P.B.), McGill University, Montreal, Canada.
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Samy Suissa
From the Centre for Clinical Epidemiology (L.S., C.R., S.D., S.S., P.B.), Jewish General Hospital; McGill University Research Centre for Studies in Aging (S.G.), Douglas Mental Health University Institute; and Departments of Neurology and Neurosurgery (C.R.) and Medicine and Epidemiology, Biostatistics, and Occupational Health (C.R., S.S., P.B.), McGill University, Montreal, Canada.
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Paul Brassard
From the Centre for Clinical Epidemiology (L.S., C.R., S.D., S.S., P.B.), Jewish General Hospital; McGill University Research Centre for Studies in Aging (S.G.), Douglas Mental Health University Institute; and Departments of Neurology and Neurosurgery (C.R.) and Medicine and Epidemiology, Biostatistics, and Occupational Health (C.R., S.S., P.B.), McGill University, Montreal, Canada.
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Citation
Comparative effect of statins on the risk of incident Alzheimer disease
Liliya Sinyavskaya, Serge Gauthier, Christel Renoux, Sophie Dell'Aniello, Samy Suissa, Paul Brassard
Neurology Jan 2018, 90 (3) e179-e187; DOI: 10.1212/WNL.0000000000004818

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Article Information

vol. 90 no. 3 e179-e187
DOI: 
https://doi.org/10.1212/WNL.0000000000004818
PubMed: 
29247073

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 20, 2017
  • Accepted in final form September 19, 2017
  • First Published December 15, 2017.

Article Versions

  • Previous version (December 15, 2017 - 12:40).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2017 American Academy of Neurology

Author Disclosures

    1. Liliya Sinyavskaya, MD, MPH,
    2. Serge Gauthier, MD,
    3. Christel Renoux, MD, MSc, PhD,
    4. Sophie Dell'Aniello, MSc,
    5. Samy Suissa, PhD and
    6. Paul Brassard, MD, MSc
  1. Liliya Sinyavskaya, MD, MPH,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1)Non-profit organization Canadian Network for Observational Drug Effect Studies (CNODES), A scholarships for participation and poster presentation at the 33rd ICPE International Conference of Pharmacoepidemiology and therapeutic Risk Management

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other activities:
    1. (1)Non-profit organization Canadian Network for Observational Drug Effect Studies (CNODES), A scholarships for participation in the University of McGill summer courses on pharmacoepidemiology (Montreal, Canada) (2)Non-profit organization Canadian Network for Observational Drug Effect Studies (CNODES), PhD scholarship (3)Non-profit organization National Institute of Health, US Department of Health and Human Services. Fogarty International Center. Fogarty international training and research program. Graduate scholarship for MPH program

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Serge Gauthier, MD,
  4. Scientific Advisory Boards:
    1. DSMB (1) Commercia entity: Eisai (2) Non-commercial entities: ATRI, ADCS, Banner-Health Scientific advisor, commercial entities: Boeringer- Ingelheim, TauRx, Lilly

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Commercial entity support for lectures at International congress: Schwabe

    Editorial Boards:
    1. Alzheimer's & Dementia, member of editorial board, 2017-, no compensation

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. 1. Non-profit entity: Kalgene

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Commercial entities: Lundbeck, Roche, Lilly

    Research Support, Government Entities:
    1. CIHR grant support

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Christel Renoux, MD, MSc, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Sophie Dell'Aniello, MSc,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Samy Suissa, PhD and
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Paul Brassard, MD, MSc
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Centre for Clinical Epidemiology (L.S., C.R., S.D., S.S., P.B.), Jewish General Hospital; McGill University Research Centre for Studies in Aging (S.G.), Douglas Mental Health University Institute; and Departments of Neurology and Neurosurgery (C.R.) and Medicine and Epidemiology, Biostatistics, and Occupational Health (C.R., S.S., P.B.), McGill University, Montreal, Canada.
  1. Correspondence
    Dr. Brassard paul.brassard{at}mcgill.ca
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