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January 16, 2018; 90 (3) Article

Nutrients and bioactives in green leafy vegetables and cognitive decline

Prospective study

Martha Clare Morris, Yamin Wang, Lisa L. Barnes, David A. Bennett, Bess Dawson-Hughes, Sarah L. Booth
First published December 20, 2017, DOI: https://doi.org/10.1212/WNL.0000000000004815
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Article Information

vol. 90 no. 3 e214-e222
DOI: 
https://doi.org/10.1212/WNL.0000000000004815
PubMed: 
29263222
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received February 20, 2017
  • Accepted in final form September 29, 2017
  • First Published December 20, 2017.

Article Versions

Copyright & Usage: 
Copyright © 2017 American Academy of Neurology

Author Disclosures

    1. Martha Clare Morris, ScD,
    2. Yamin Wang, PhD,
    3. Lisa L. Barnes, PhD,
    4. David A. Bennett, MD,
    5. Bess Dawson-Hughes, MD and
    6. Sarah L. Booth, PhD
  1. Martha Clare Morris, ScD,
    2. Scientific Advisory Boards:

    1. 1. University of Chicago, $3,000 CTSA executive committee 2. Natrol, $1,666.66 Scientific advisory board 3. Global Council for Brain Health (AARP) scientific advisory board ($200)

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. 1. Physicians' Committee for Responsible Medicine, $1000

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. NIH/NIA - AG052583, PI, 2016-2021 2.NIH/NIA - AG054476, PI, 2017-2022 3. NIH/NIA - AG054057, MPI, 2016-2021 4. NIH/NIA - AG051641, MPI, 2016-2021

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. Consolidated Anti-Aging Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Yamin Wang, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Lisa L. Barnes, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Aging And Health, member of editorial board, 2006 - present. No compensation received.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1)NIA, P30-AG10161, PI of Clinical Core, 9/30/91 ? 6/30/21 (2)NIA, RF1-AG22018, PI, 8/01/2010-7/31/2021 (3)NIMHD,P20-MD6886, PI 6/15/2012 - 2/1/2017 (4)NIA, P30AG17917, Co-I 9/30/01-3/31/19 (5) NIA, RF1AG51641, Co-I 9/1/16-6/30/21 (6) NIA, U2CAAG54397, Co-I 9/30/16-4/30/20 (7) NIA, R01AG51635, Co-I 6/1/16-5/31/21 (8) NIA, R01AG52583, Co-I 4/1/16-3/31/21 (9) NIA, RF1AG54057, Co-I 9/1/16-5/31/21

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. David A. Bennett, MD,
    5. Scientific Advisory Boards:

    1. (1) Vigorous Minds, Scientific Advisory Board (2) Takeda Pharm - Adjudication committee AD4833/TOMM40_301 study (3) AbbVie - Data Monitoring Committee

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Neurology, Editorial Board; (2) Current Alzheimer Research, Editorial Board; (3) Neuroepidemiology, Editorial Board

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH: P30AG10161, PI; RF1AG15819, PI; R01AG17917, PI; R01AG36042, PI; R01AG54058, PI; U01AG46152, MPI; U01AG46161, MPI; R01AG33678, co-I; R01AG34374, co-I;

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Bess Dawson-Hughes, MD and
    6. Scientific Advisory Boards:

    1. Amgen - scientific advisory board Triceda - scientific advisory board DSMB - MrOS (NIH)

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Pfizer- gave 2 lectures in China on calcium; expenses covered and honorarium to be received

    Editorial Boards:

    1. Osteoporosis International editorial board 2005-current Bone - editorial board 2004 - current Calcified Tissue International - editorial board 2015 - current

    Patents:

    1. NONE

    Publishing Royalties:

    1. Up-to-Date author of Vitamin D section,MASS Med Soc, updated online twice yearly

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultancies only as listed in question 1.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Pfizer and DSM have co-funded an investigator-initiated research project on vitamin D and muscle in my lab

    Research Support, Government Entities:

    1. Research grant, NIH, PI, R21 AR067528 8/5/16-7/31/18 Research grant, NIH, PI, RO1 AR060261 9/1/11-8/31/15 Research grant, NIH, co-inv, UO1 DK098245 6/1/13-5/31/18 Research grant, NIH, mentor, KO1 AR067894 3/1/15-2/28/20 Research grant, NIH, co-inv, ROI AG051641 7/1/16-6/30/21 USDA research funding, PI, 9/15/14-9/14/19 Pfizer-DSM, PI, 1/15/15-12/30/18

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. International Osteoporosis Foundation - Trustee since 2004 and General Secretariat since 2008

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Sarah L. Booth, PhD
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Current Developments in Nutrition, Deputy Editor, 2016 to current

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 08/16/15-07/31/17 Abbott Laboratories Biomarkers of Healthy Brain Aging in the Illinois Elderly Adult Cohort The major goal of the project is to identify distinct nutrient biomarker patterns and examine association between these patterns and cognitive indices of brain health Role: Co-Investigator JohnsonIllinois2017 Johnson (PI)

    Research Support, Government Entities:

    1. 1R01AG051641-01A1 Booth/Morris (MPI) 09/01/16-08/30/21 NIH/NIA Vitamins D and K and Neuropathologically-Defined Alzheimer and Other Dementias in Older Persons The major goal of this project is to understand vitamin D and K?s role in Alzheimer's disease and related dementias of aging. Role: Contact PI 1950-51000-069-02S Booth (PI) 09/15/14-09/14/19 USDA/ARS Vitamin K and Vitamin K-Dependent Proteins During Aging The major goal of this project is to enhance scientific knowledge on the physiological benefits of increased vitamin K consumption in order to develop more precise vitamin K intake recommendations. Role: PI R01AR066378 McAlindon (PI) 04/01/15- 09/30/18 NIH/ NIAMS Constitutional and Metabolic Factors associated with the development of Hand OA The goal of this project is to evaluate and contrast the roles of structural and metabolic characteristics in the development of radiographic, symptomatic and erosive hand osteoarthritis. Role: Consortium PI Illinois2017 Booth (PI) K01 AR063167 Shea (PI) 08/01/12-07/31/17 NIH/NIAMS Identifying Vitamin K Dependent Pathways in Osteoarthritis Progression The purpose of the study is to determine the effect of vitamin K and D on osteoarthritis progression and elucidate mechanisms through which vitamins D & K influences cartilage homeostasis. Role: Mentor and Co-Investigator

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Internal Medicine (M.C.M., Y.W.), Preventive Medicine (Y.W.), Behavioral Sciences (L.L.B.), and Neurological Sciences (L.L.B., D.A.B.), and Rush Alzheimer Disease Center (L.L.B., D.A.B.), Rush University, Chicago, IL; and Tufts Human Nutrition Research Center on Aging (B.D.-H., S.L.B.), Tufts University, Boston, MA.
  1. Correspondence
    Dr. Morris Martha_C_Morris{at}rush.edu
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