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January 16, 2018; 90 (3) Resident and Fellow Section

Teaching NeuroImages: Gasperini syndrome

Raffaele Iorio
First published January 15, 2018, DOI: https://doi.org/10.1212/WNL.0000000000004836
Raffaele Iorio
From the Institute of Neurology, Fondazione Policlinico Universitario “Agostino Gemelli,” Università Cattolica del Sacro Cuore, Rome, Italy.
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Teaching NeuroImages: Gasperini syndrome
Raffaele Iorio
Neurology Jan 2018, 90 (3) e261; DOI: 10.1212/WNL.0000000000004836

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A 62-year-old woman acutely developed left facial weakness, diplopia on left gaze, and right-sided numbness including her face. Brain MRI revealed an ischemic lesion of the lower pontine tegmentum (figure 1).

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Figure 1 Brain MRI

Brain MRI shows restricted diffusion in the caudal portion of the left pons (A) with corresponding hyperintensity on axial fluid-attenuated inversion recovery (B) and coronal T2-weighted images (C).

Gasperini syndrome is a rare crossed brainstem syndrome characterized by ipsilateral impairment of the VI, VII, and occasionally VIII cranial nerves and contralateral sensory loss. The syndrome, initially described by Ubaldo Gasperini in 1912, results from a lesion of the caudal pons tegmentum1,2 (figure e-1, links.lww.com/WNL/A47). The most frequent cause is the occlusion of the long circumferential branch of the anterior inferior cerebellar artery.

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No targeted funding reported.

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R. Iorio reports no disclosures relevant to the manuscript. Got to Neurology.org for full disclosures.

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  • Go to Neurology.org/N for full disclosures.

  • Teaching slides: links.lww.com/WNL/A47

  • Copyright © 2018 American Academy of Neurology

References

  1. 1.↵
    1. Tacik P,
    2. Alfieri A,
    3. Kornhuber M,
    4. Dressler D
    . Gasperini's syndrome: its neuroanatomical basis now and then. J Hist Neurosc 2012;21:17–30.
    OpenUrl
  2. 2.↵
    1. Hayashi-Hayata M,
    2. Nakayasu H,
    3. Doi M,
    4. Fukada Y,
    5. Murakami T,
    6. Nakashima K
    . Gasperini syndrome, a report of two cases. Intern Med 2007;46:129–133.
    OpenUrlPubMed

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