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February 27, 2018; 90 (9) Article

Prescription of antihypertensive medication at discharge influences survival following stroke

Nadine E. Andrew, Joosup Kim, Amanda G. Thrift, Monique F. Kilkenny, Natasha A. Lannin, Craig S. Anderson, Geoffrey A. Donnan, Kelvin Hill, Sandy Middleton, Christopher Levi, Steven Faux, Rohan Grimley, Nisal Gange, Richard Geraghty, Sharan Ermel, Dominique A. Cadilhac
First published January 31, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005023
Nadine E. Andrew
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Joosup Kim
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Amanda G. Thrift
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Monique F. Kilkenny
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Natasha A. Lannin
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Craig S. Anderson
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Geoffrey A. Donnan
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Kelvin Hill
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Sandy Middleton
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Christopher Levi
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Steven Faux
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Rohan Grimley
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Nisal Gange
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Richard Geraghty
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Sharan Ermel
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Dominique A. Cadilhac
From Stroke & Ageing Research (N.E.A., J.K., A.G.T., M.F.K., R.G., D.A.C.), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton; Department of Medicine (N.E.A), Peninsula Clinical School, Central Clinical School, Monash University, Frankston; Florey Institute of Neuroscience and Mental Health (J.K., M.F.K., G.A.D., D.A.C.), University of Melbourne, Heidelberg; School of Allied Health (Occupational Therapy) (N.A.L.), La Trobe University, Bundoora; Occupational Therapy Department (N.A.L.), Alfred Health, Melbourne; Faculty of Medicine (C.S.A.), The University of New South Wales, Sydney; Stroke Foundation (K.H.), Melbourne; Nursing Research Institute (S.M.), St Vincent's Health Australia, Sydney and Australian Catholic University, Sydney; University of New South Wales and the Partnership for Health Education, Research and Enterprise (SPHERE) (C.L.), Sydney; Faculty of Medicine (S.F.), The University of New South Wales, Sydney and St Vincent's Health Australia, Sydney; Statewide Stroke Clinical Network (R.G.), Queensland Health, Brisbane; Sunshine Coast Clinical School (R.G), The University of Queensland, Birtinya; Toowoomba Hospital (N.G.), Toowoomba; Redcliffe Hospital (R.G.), Brisbane; and Bendigo Health (S.E.), Bendigo, Australia.
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Full PDF
Citation
Prescription of antihypertensive medication at discharge influences survival following stroke
Nadine E. Andrew, Joosup Kim, Amanda G. Thrift, Monique F. Kilkenny, Natasha A. Lannin, Craig S. Anderson, Geoffrey A. Donnan, Kelvin Hill, Sandy Middleton, Christopher Levi, Steven Faux, Rohan Grimley, Nisal Gange, Richard Geraghty, Sharan Ermel, Dominique A. Cadilhac
Neurology Feb 2018, 90 (9) e745-e753; DOI: 10.1212/WNL.0000000000005023

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Abstract

Objective To investigate the risk of death from cardiovascular disease between patients who were and were not prescribed antihypertensive medication following stroke or TIA.

Methods This was a large cohort study using routinely collected prospective data from the Australian Stroke Clinical Registry. Patients registered between 2009 and 2013 who were discharged to the community or rehabilitation were included. Cases were linked to the National Death Index to determine the date and cause of death. Propensity score matching with stratification was utilized to compare between similar subgroups of patients. Multivariable competing risks regression, with noncardiovascular death as a competing risk, was conducted to investigate the association between the prescription of antihypertensive medications and cardiovascular death at 180 days after admission.

Results Among 12,198 patients from 40 hospitals, 70% were prescribed antihypertensive medications. Patients who were older, were treated in a stroke unit, and had better socioeconomic position were more often discharged from hospital with an antihypertensive medication. Including only patients within propensity score quintiles with acceptable levels of balance in covariates between groups (n = 8,786), prescription of antihypertensive medications was associated with a 23% greater reduction in the subhazard of cardiovascular death compared to those who were not prescribed these agents (subhazard ratio 0.77; 95% confidence interval 0.61 to 0.97).

Conclusions People who are prescribed antihypertensive medications at discharge from hospital after a stroke or TIA demonstrate better cardiovascular and all-cause survival outcomes than those not prescribed these agents.

Glossary

AHA=
American Heart Association;
AuSCR=
Australian Stroke Clinical Registry;
CI=
confidence interval;
CVD=
cardiovascular disease;
ICD-10=
International Classification of Diseases–10;
ICH=
intracerebral hemorrhage;
IRSAD=
Index of Relative Advantage and Disadvantage;
NDI=
National Death Index;
SHR=
subhazard ratio

Footnotes

  • ↵* These authors contributed equally to this work.

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Coinvestigators are listed at http://links.lww.com/WNL/A266.

  • Received June 1, 2017.
  • Accepted in final form November 27, 2017.
  • © 2018 American Academy of Neurology
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