Skip to main content
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

September 25, 2018; 91 (13) Article

Surgery and risk of Guillain-Barré syndrome

A French nationwide epidemiologic study

Jérémie Rudant, Axelle Dupont, Yann Mikaeloff, Francis Bolgert, Joël Coste, Alain Weill
First published August 24, 2018, DOI: https://doi.org/10.1212/WNL.0000000000006246
Jérémie Rudant
From Caisse Nationale de l'Assurance Maladie (J.R., A.D., J.C., A.W.), Direction de la Stratégie des Études et des Statistiques, Département Études en Santé Publique, Paris; Assistance Publique–Hôpitaux de Paris (Y.M.), Hôpital Bicêtre, Unité de Rééducation Neurologique Infantile, Bicêtre; Université Paris-Saclay (Y.M.), Université Paris-Sud, CESP, Inserm, Villejuif; and Assistance Publique–Hôpitaux de Paris (F.B.), Hôpital Pitié-Salpêtrière, Réanimation Neurologique, Neurologie 1, Paris, France.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Axelle Dupont
From Caisse Nationale de l'Assurance Maladie (J.R., A.D., J.C., A.W.), Direction de la Stratégie des Études et des Statistiques, Département Études en Santé Publique, Paris; Assistance Publique–Hôpitaux de Paris (Y.M.), Hôpital Bicêtre, Unité de Rééducation Neurologique Infantile, Bicêtre; Université Paris-Saclay (Y.M.), Université Paris-Sud, CESP, Inserm, Villejuif; and Assistance Publique–Hôpitaux de Paris (F.B.), Hôpital Pitié-Salpêtrière, Réanimation Neurologique, Neurologie 1, Paris, France.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yann Mikaeloff
From Caisse Nationale de l'Assurance Maladie (J.R., A.D., J.C., A.W.), Direction de la Stratégie des Études et des Statistiques, Département Études en Santé Publique, Paris; Assistance Publique–Hôpitaux de Paris (Y.M.), Hôpital Bicêtre, Unité de Rééducation Neurologique Infantile, Bicêtre; Université Paris-Saclay (Y.M.), Université Paris-Sud, CESP, Inserm, Villejuif; and Assistance Publique–Hôpitaux de Paris (F.B.), Hôpital Pitié-Salpêtrière, Réanimation Neurologique, Neurologie 1, Paris, France.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francis Bolgert
From Caisse Nationale de l'Assurance Maladie (J.R., A.D., J.C., A.W.), Direction de la Stratégie des Études et des Statistiques, Département Études en Santé Publique, Paris; Assistance Publique–Hôpitaux de Paris (Y.M.), Hôpital Bicêtre, Unité de Rééducation Neurologique Infantile, Bicêtre; Université Paris-Saclay (Y.M.), Université Paris-Sud, CESP, Inserm, Villejuif; and Assistance Publique–Hôpitaux de Paris (F.B.), Hôpital Pitié-Salpêtrière, Réanimation Neurologique, Neurologie 1, Paris, France.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joël Coste
From Caisse Nationale de l'Assurance Maladie (J.R., A.D., J.C., A.W.), Direction de la Stratégie des Études et des Statistiques, Département Études en Santé Publique, Paris; Assistance Publique–Hôpitaux de Paris (Y.M.), Hôpital Bicêtre, Unité de Rééducation Neurologique Infantile, Bicêtre; Université Paris-Saclay (Y.M.), Université Paris-Sud, CESP, Inserm, Villejuif; and Assistance Publique–Hôpitaux de Paris (F.B.), Hôpital Pitié-Salpêtrière, Réanimation Neurologique, Neurologie 1, Paris, France.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alain Weill
From Caisse Nationale de l'Assurance Maladie (J.R., A.D., J.C., A.W.), Direction de la Stratégie des Études et des Statistiques, Département Études en Santé Publique, Paris; Assistance Publique–Hôpitaux de Paris (Y.M.), Hôpital Bicêtre, Unité de Rééducation Neurologique Infantile, Bicêtre; Université Paris-Saclay (Y.M.), Université Paris-Sud, CESP, Inserm, Villejuif; and Assistance Publique–Hôpitaux de Paris (F.B.), Hôpital Pitié-Salpêtrière, Réanimation Neurologique, Neurologie 1, Paris, France.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Short Form
Citation
Surgery and risk of Guillain-Barré syndrome
A French nationwide epidemiologic study
Jérémie Rudant, Axelle Dupont, Yann Mikaeloff, Francis Bolgert, Joël Coste, Alain Weill
Neurology Sep 2018, 91 (13) e1220-e1227; DOI: 10.1212/WNL.0000000000006246

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
772

Share

  • Article
  • Figures & Data
  • Info & Disclosures
  • CME Course
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective To assess the association between Guillain-Barré syndrome (GBS) and recent surgery based on French nationwide data.

Methods Data were extracted from the French health administrative databases (SNIIRAM/PMSI). All patients hospitalized for GBS between 2009 and 2014 were identified by ICD-10 code G61.0 as main diagnosis. Patients previously hospitalized for GBS in 2006, 2007, and 2008 were excluded. Surgical procedures were identified from the hospital database. Hospitalizations for surgery with no infection diagnosis code entered during the hospital stay were also identified. The association between GBS and a recent surgical procedure was estimated using a case-crossover design. Case and referent windows were defined as 1–60 days and 366–425 days before GBS hospitalization, respectively. Analyses were adjusted for previous episodes of gastroenteritis and respiratory tract infection, identified by drug dispensing data.

Results Of the 8,364 GBS cases included, 175 and 257 patients had undergone a surgical procedure in the referent and case windows, respectively (adjusted odds ratio [OR] = 1.53, 95% confidence interval [CI]: 1.25–1.88). A slightly weaker association was observed for surgical procedures with no identified infection during the hospitalization (OR = 1.40, 95% CI: 1.12–1.73). Regarding the type of surgery, only surgical procedures on bones and digestive organs were significantly associated with GBS (OR and 95% CI = 2.78 [1.68–4.60] and 2.36 [1.32–4.21], respectively).

Conclusion In this large nationwide epidemiologic study, GBS was moderately associated with any type of recent surgery and was more strongly associated with bone and digestive organ surgery.

Glossary

CI=
confidence interval;
GBS=
Guillain-Barré syndrome;
ICD-10=
International Classification of Diseases, Tenth Revision;
OR=
odds ratio;
PMSI=
Programme de Médicalisation des Systèmes d'Information;
SNIIRAM=
Système National d'Information Interrégimes de l'Assurance Maladie

Footnotes

  • ↵* These authors contributed equally to this work.

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • CME Course: NPub.org/cmelist

  • Received February 19, 2018.
  • Accepted in final form June 28, 2018.
  • © 2018 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

  • Author response to Dr. Steiner
    • Jérémie Rudant, Epidemiologist, Caisse Nationale de l’Assurance Maladie
    • Axelle Dupont, Epidemiologist, Caisse Nationale de l’Assurance Maladie
    • Yann Mikaeloff, Neurologist, Hopital Bicetre, Unite de Reeducation Neurologique Infantile
    • Francis Bolgert, Neurologist, Hopital Pitie-Salpetriere, Reanimation Neurologique, Neurologie 1
    • Joël Coste, Epidemiologist, Caisse Nationale de l’Assurance Maladie
    • Alain Weill, Epidemiologist, Caisse Nationale de l’Assurance Maladie
    Submitted January 08, 2019
  • Guillain-Barré syndrome following surgery
    • Israel Steiner, Neurologist, Rabin Medical Center
    Submitted December 18, 2018
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Author contributions
    • Study funding
    • Disclosure
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures
  • CME Course

More Online

CME Course

Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials

Dr. Nicole Sur and Dr. Mausaminben Hathidara

► Watch

Topics Discussed

  • Guillain-Barre syndrome
  • Risk factors in epidemiology

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Article
    Association of Hospital-Diagnosed Infections and Antibiotic Use With Risk of Developing Guillain-Barré Syndrome
    Lotte S. Levison, Reimar W. Thomsen, Søren H. Sindrup et al.
    Neurology, December 14, 2020
  • Null Hypothesis
    Seasonal influenza vaccine and Guillain-Barré syndrome
    A self-controlled case series study
    Clémence Grave, Pauline Boucheron, Jérémie Rudant et al.
    Neurology, February 25, 2020
  • Research
    Clinical factors associated with Guillain-Barré syndrome following surgery
    Sara Hocker, Elanagan Nagarajan, Mark Rubin et al.
    Neurology: Clinical Practice, May 24, 2018
  • Articles
    The spectrum of antecedent infections in Guillain-Barré syndrome
    A case-control study
    B. C. Jacobs, P. H. Rothbarth, F.G.A. van der Meché et al.
    Neurology, October 01, 1998
Neurology: 100 (23)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise