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October 23, 2018; 91 (17) Article

Global and regional brain hypometabolism on FDG-PET in treated HIV-infected individuals

Dima A. Hammoud, Sanhita Sinharay, Sally Steinbach, Paul G. Wakim, Katrina Geannopoulos, Katherine Traino, Amit K. Dey, Edmund Tramont, Stanley I. Rapoport, Joseph Snow, Nehal N. Mehta, Bryan R. Smith, Avindra Nath
First published September 26, 2018, DOI: https://doi.org/10.1212/WNL.0000000000006398
Dima A. Hammoud
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Sanhita Sinharay
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Sally Steinbach
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Paul G. Wakim
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Katrina Geannopoulos
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Katherine Traino
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Amit K. Dey
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Edmund Tramont
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Stanley I. Rapoport
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Joseph Snow
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Nehal N. Mehta
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Bryan R. Smith
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Avindra Nath
From the Center for Infectious Disease Imaging, Radiology and Imaging Sciences (D.A.H., S. Sinharay), Clinical Center, National Institute of Neurological Diseases and Stroke (S. Steinbach, K.G., B.R.S., A.N.), Biostatistics and Clinical Epidemiology Service (P.G.W.), Clinical Center, National Institute of Mental Health (K.T., J.S.), National Heart, Lung, and Blood Institute (A.K.D., N.N.M.), National Institute for Allergy and Infectious Diseases (E.T.), and National Institute on Alcohol Abuse and Alcoholism (S.I.R.), NIH, Bethesda, MD.
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Citation
Global and regional brain hypometabolism on FDG-PET in treated HIV-infected individuals
Dima A. Hammoud, Sanhita Sinharay, Sally Steinbach, Paul G. Wakim, Katrina Geannopoulos, Katherine Traino, Amit K. Dey, Edmund Tramont, Stanley I. Rapoport, Joseph Snow, Nehal N. Mehta, Bryan R. Smith, Avindra Nath
Neurology Oct 2018, 91 (17) e1591-e1601; DOI: 10.1212/WNL.0000000000006398

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Abstract

Objective To quantitatively measure brain glucose metabolism in treated HIV-positive individuals with [18F]-labeled fluorodeoxyglucose (FDG) PET/CT.

Methods We performed a cross-sectional comparison of FDG uptake in 47 treated HIV+ individuals, 10 age-matched controls (HIV−) sharing many of the comorbid conditions seen in the HIV+ group, and 19 age-matched healthy controls (HCs). We compared whole-brain (WB) and regional FDG standardized uptake values (SUVs) of select subcortical/central structures among the groups and correlated the values to clinical and neuropsychological assessments. A variable selection model was used to predict SUVs in HIV+ (n = 47) and in combined HIV+ and HIV− participants (n = 57).

Results We found lower WB SUVmax in HIV+ participants compared to HCs but not to HIV− participants. Among the relative SUVmean measurements (regional SUVmean/WB SUVmean), only relative thalamic uptake values were lower in HIV+ compared to HIV− participants. When HIV+ and HIV− participants were grouped, cardiovascular disease risk scores best predicted WB SUVmean and SUVmax, while HIV status best predicted thalamic relative SUVmean.

Conclusions We identified an important role for cardiovascular disease in neuronal loss/dysfunction, as measured by FDG-PET, in treated HIV+ patients. This underscores the need for shifting the focus of clinical intervention in this vulnerable population from HIV effects alone to a wider set of comorbid conditions, mainly cardiovascular disease. Only the thalamus showed significantly lower relative uptake in the HIV+ compared to the HC and HIV− groups. This needs to be further evaluated for underlying pathophysiology and potential association with memory, executive functioning, and attention deficits seen in the HIV+ population.

Glossary

ART=
antiretroviral therapy;
ASCVD=
atherosclerotic cardiovascular disease;
BMI=
body mass index;
CI=
confidence interval;
DBP=
diastolic blood pressure;
FBS=
fasting blood sugar;
FDG=
[18F]-labeled fluorodeoxyglucose;
HAND=
HIV-associated neurocognitive disorders;
HC=
healthy control;
HCV=
hepatitis C;
SBP=
systolic blood pressure;
SUV=
standardized uptake value;
VL=
viral load;
VOI=
volume of interest;
WB=
whole brain

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received May 10, 2018.
  • Accepted in final form July 16, 2018.
  • © 2018 American Academy of Neurology
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