Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

November 06, 2018; 91 (19) Views & Reviews

Clinical correlates of quantitative EEG in Parkinson disease

A systematic review

Victor J. Geraedts, Lennard I. Boon, Johan Marinus, Alida A. Gouw, Jacobus J. van Hilten, Cornelis J. Stam, Martijn R. Tannemaat, Maria Fiorella Contarino
First published October 5, 2018, DOI: https://doi.org/10.1212/WNL.0000000000006473
Victor J. Geraedts
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lennard I. Boon
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Johan Marinus
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alida A. Gouw
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jacobus J. van Hilten
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cornelis J. Stam
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martijn R. Tannemaat
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Fiorella Contarino
From the Department of Neurology (V.J.G., J.M., J.J.v.H., M.R.T., M.F.C.), Leiden University Medical Center; Department of Clinical Neurophysiology and MEG Center (V.J.G., L.I.B., A.A.G., C.J.S.) and Alzheimer Center, Department of Neurology (A.A.G.), VU University Medical Center, Amsterdam; and Department of Neurology (M.F.C.), Haga Teaching Hospital, The Hague, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Clinical correlates of quantitative EEG in Parkinson disease
A systematic review
Victor J. Geraedts, Lennard I. Boon, Johan Marinus, Alida A. Gouw, Jacobus J. van Hilten, Cornelis J. Stam, Martijn R. Tannemaat, Maria Fiorella Contarino
Neurology Nov 2018, 91 (19) 871-883; DOI: 10.1212/WNL.0000000000006473

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
692

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective To assess the relevance of quantitative EEG (qEEG) measures as outcomes of disease severity and progression in Parkinson disease (PD).

Methods Main databases were systematically searched (January 2018) for studies of sufficient methodologic quality that examined correlations between clinical symptoms of idiopathic PD and cortical (surface) qEEG metrics.

Results Thirty-six out of 605 identified studied were included. Results were classified into 4 domains: cognition (23 studies), motor function (13 studies), responsiveness to interventions (7 studies), and other (10 studies). In cross-sectional studies, EEG slowing correlated with global cognitive impairment and with diffuse deterioration in other domains. In longitudinal studies, decreased dominant frequency and increased θ power, reflecting EEG slowing, were biomarkers of cognitive deterioration at an individual level. Results on motor dysfunction and treatment yielded contrasting findings. Studies on functional connectivity at an individual level and longitudinal studies on other domains or on connectivity measures were lacking.

Conclusion qEEG measures reflecting EEG slowing, particularly decreased dominant frequency and increased θ power, correlate with cognitive impairment and predict future cognitive deterioration. qEEG could provide reliable and widely available biomarkers for nonmotor disease severity and progression in PD, potentially promoting early diagnosis of nonmotor symptoms and an objective monitoring of progression. More studies are needed to clarify the role of functional connectivity and network analyses.

Glossary

BRF=
background rhythm frequency;
DBS=
deep brain stimulation;
EWCI=
edge-wise connectivity index;
FFT=
fast Fourier transformation;
H&Y=
Hoehn & Yahr;
JBI=
Joanna Briggs Institute;
LFP=
local field potentials;
MCI=
mild cognitive impairment;
MDS-UPDRS III=
Movement Disorders Society–Unified Parkinson's Disease Rating Scale III;
MEG=
magnetoencephalography;
MST=
minimum spanning trees;
NCOG=
cognitively normal;
PD=
Parkinson disease;
PDD=
Parkinson disease dementia;
PLI=
phase-lag index;
PLV=
phase-locking value;
PRISMA=
Preferred Reporting Items for Systematic Reviews and Meta-Analyses;
qEEG=
quantitative EEG;
RBD=
REM sleep behavior disorder;
WN=
weighted network

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • © 2018 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Author contributions
    • Study funding
    • Disclosure
    • Publication history
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures
Advertisement

Related Articles

  • No related articles found.

Topics Discussed

  • Parkinson's disease/Parkinsonism

Alert Me

  • Alert me when eletters are published
Neurology: 96 (15)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise