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July 10, 2018; 91 (2) Article

Incidence of sudden unexpected death in epilepsy in children is similar to adults

Anne E. Keller, Robyn Whitney, Shelly-Anne Li, Michael S. Pollanen, Elizabeth J. Donner
First published June 8, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005762
Anne E. Keller
From the Division of Neurology (A.E.K.) and Child Health Evaluative Sciences (S.-A.L.), Hospital for Sick Children, Toronto; Division of Neurology (R.W., E.J.D.), Department of Paediatrics, Hospital for Sick Children, University of Toronto; and Department of Laboratory Medicine and Pathobiology (M.S.P.), University of Toronto, Canada.
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Robyn Whitney
From the Division of Neurology (A.E.K.) and Child Health Evaluative Sciences (S.-A.L.), Hospital for Sick Children, Toronto; Division of Neurology (R.W., E.J.D.), Department of Paediatrics, Hospital for Sick Children, University of Toronto; and Department of Laboratory Medicine and Pathobiology (M.S.P.), University of Toronto, Canada.
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Shelly-Anne Li
From the Division of Neurology (A.E.K.) and Child Health Evaluative Sciences (S.-A.L.), Hospital for Sick Children, Toronto; Division of Neurology (R.W., E.J.D.), Department of Paediatrics, Hospital for Sick Children, University of Toronto; and Department of Laboratory Medicine and Pathobiology (M.S.P.), University of Toronto, Canada.
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Michael S. Pollanen
From the Division of Neurology (A.E.K.) and Child Health Evaluative Sciences (S.-A.L.), Hospital for Sick Children, Toronto; Division of Neurology (R.W., E.J.D.), Department of Paediatrics, Hospital for Sick Children, University of Toronto; and Department of Laboratory Medicine and Pathobiology (M.S.P.), University of Toronto, Canada.
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Elizabeth J. Donner
From the Division of Neurology (A.E.K.) and Child Health Evaluative Sciences (S.-A.L.), Hospital for Sick Children, Toronto; Division of Neurology (R.W., E.J.D.), Department of Paediatrics, Hospital for Sick Children, University of Toronto; and Department of Laboratory Medicine and Pathobiology (M.S.P.), University of Toronto, Canada.
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Incidence of sudden unexpected death in epilepsy in children is similar to adults
Anne E. Keller, Robyn Whitney, Shelly-Anne Li, Michael S. Pollanen, Elizabeth J. Donner
Neurology Jul 2018, 91 (2) e107-e111; DOI: 10.1212/WNL.0000000000005762

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Abstract

Objective To determine the incidence of sudden unexpected death in epilepsy (SUDEP) in children in Ontario, Canada.

Methods Cases of suspected pediatric SUDEP occurring between January 1, 2014, and December 31, 2015, in Ontario, Canada, were eligible for inclusion. Potential cases were identified through 3 sources: a national pediatrician surveillance program, child neurologist report, and screening of provincial forensic autopsies. Cases were classified as definite, definite plus, probable, possible, and near/near plus according to criteria described by Nashef et al. (Epilepsia 2012). Overall crude pediatric SUDEP incidence and the incidence of definite or probable pediatric SUDEP were calculated using estimates of the prevalence of pediatric epilepsy in Canada drawn from government survey data and the number of children living in Ontario. Capture-recapture analysis was used to estimate the number of missing cases and determine an adjusted definite/probable SUDEP incidence.

Results Seventeen cases of pediatric SUDEP resulted in an overall incidence of 1.17 (95% confidence interval 0.68–1.88) per 1,000 pediatric epilepsy person-years. The definite/probable incidence, including definite (n = 11), definite plus (n = 2), or probable (n = 3) SUDEP cases, was 1.11 (0.63–1.79). Capture-recapture analysis indicated an estimated 21 (16–39) definite/probable SUDEP cases occurred during the study period, giving an adjusted incidence of definite/probable SUDEP of 1.45 (0.90–2.22) per 1,000 pediatric epilepsy person-years.

Conclusion SUDEP may be more common in children than widely reported, with the incidence rate of definite/probable SUDEP in children being similar to rates reported in adults.

Glosssary

AAN=
American Academy of Neurology;
AES=
American Epilepsy Society;
SUDEP=
sudden unexpected death in epilepsy

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Editorial Page 57

  • Received October 26, 2017.
  • Accepted in final form March 26, 2018.
  • © 2018 American Academy of Neurology
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