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December 11, 2018; 91 (24) Article

Body mass index, but not vitamin D status, is associated with brain volume change in MS

Ellen M. Mowry, Christina J. Azevedo, Charles E. McCulloch, Darin T. Okuda, Robin R. Lincoln, Emmanuelle Waubant, Stephen L. Hauser, Daniel Pelletier
First published November 14, 2018, DOI: https://doi.org/10.1212/WNL.0000000000006644
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Article Information

vol. 91 no. 24 e2256-e2264
DOI: 
https://doi.org/10.1212/WNL.0000000000006644
PubMed: 
30429274
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received April 14, 2018
  • Accepted in final form August 27, 2018
  • First Published November 14, 2018.

Article Versions

Copyright & Usage: 
© 2018 American Academy of Neurology

Author Disclosures

    1. Ellen M. Mowry, MD, MCR,
    2. Christina J. Azevedo, MD, MPH,
    3. Charles E. McCulloch, PhD,
    4. Darin T. Okuda, MD,
    5. Robin R. Lincoln, BS,
    6. Emmanuelle Waubant, MD, PhD,
    7. Stephen L. Hauser, MD and
    8. Daniel Pelletier, MD
  1. Ellen M. Mowry, MD, MCR,
    2. Scientific Advisory Boards:

    1. DSMB for liothyronine study (non-profit)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial board, Frontiers in Neuroepidemiomology, 2017- present

    Patents:

    1. NONE

    Publishing Royalties:

    1. UptoDate chapter editor (Pathogenesis and epidemiology of multiple sclerosis)

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1)Free glatiramer acetate for a clinical trial from Teva Neuroscience. (2)Research funding paid to my institution from Biogen Idec and Genzyme (for investigator-initiated studies). (3) Site PI of two trials sponsored by Sun Pharma and Biogen

    Research Support, Government Entities:

    1. (1)Department of Defense

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1. National Multiple Sclerosis Society RG4407A22. 2. National Multiple Sclerosis Society JF2164A7 3. Patient- Centered Outcomes Research Institute (PCORI)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Christina J. Azevedo, MD, MPH,
    3. Scientific Advisory Boards:

    1. In the past two years, I have received honoraria for serving on scientific advisory boards for: (1) Genentech (2) Guerbet, L.L.C. (3) Biogen-Idec (4) Genzyme

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. I am supported by a 3-year Institutional Career Development Award through the Southern California Clinical and Translational Science Institute (Grant # UL1TR001855 from the National Center for Advancing Translational Science) My role is an Institutional Scholar.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Charles E. McCulloch, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) NIH, KL2 RR024130, Biostatistics mentor, 2010-2012

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Darin T. Okuda, MD,
    5. Scientific Advisory Boards:

    1. DSMB Chair (Osmotica)

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. 1. Acorda, travel and speaker fees 2. Genzyme, travel and speaker fees 3. Teva, travel and speaker fees

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1). Celgene (2). Bayer (3). EMD Serono (4). Genzyme (5). Novartis

    Speakers' Bureaus:

    1. (1). Acorda Therapeutics (2). Genzyme (3). TEVA

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Biogen

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Robin R. Lincoln, BS,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Emmanuelle Waubant, MD, PhD,
    7. Scientific Advisory Boards:

    1. I volunteer on a Novartis advisory board (pharmaceutical company)for a clinical trial

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. AAN has covered my travel and provided an honorarium in 2018 for my talk in Frontiers in Neurosciences

    Editorial Boards:

    1. -Section editor for Annals of Clinical and Translational Neurology since 2017 -Co-chief Editor for MSARD since 2016

    Patents:

    1. NONE

    Publishing Royalties:

    1. Demyelinating disorders of the central nervous system in childhood. Cambridge University. 2011 Pediatric MS and related disorders. 2017

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. I am site PI for trials of ocrelizumab in PPMS (Roche, company), and fingolimod in pediatric MS (Novartis, company)

    Research Support, Government Entities:

    1. I am co-PI for a trial sponsored by PCORI

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. I am supported by the National MS Society RG4861A3/1 (PI Waubant), and the Race to Erase MS (medical director)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Stephen L. Hauser, MD and
    8. Scientific Advisory Boards:

    1. Dr. Stephen L. Hauser serves on the scientific advisory boards for Bionure,Annexon,Alector, Symbiotix, and Molecular Stethoscope. He serves on the board of trustees for Neurona.

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. (1) Harrison's Principles of Internal Medicine, McGraw-Hill Publishers, 1994-present

    Employment, Commercial Entity:

    1. (1)University of California, San Francisco, Professor of Neurology, Director of the Weill Institute for Neurosciences.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH Funding, Grant # R01 NS092835 NIH Funding, Grant # R01 NS026799 NIH Funding, Grant # R01 NS099240

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National Multiple Sclerosis Society (NMSS), Grant # RR 2005-A-13 (G-1510-06785); RG-1611-26299 Conrad Hilton Foundation, 16850

    Stock/Stock Options/Board of Directors Compensation:

    1. (1)Bionure, Dr. Hauser received stock options from Bionure, all of which were transferred to his institution (UCSF) (2) Annexon, Dr. Hauser received stock options from Annexon, all of which were transferred to his institution (UCSF) (3) Symbiotix, Dr. Hauser received stock options from Symbiotix, all of which were transferred to his institution (UCSF)

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Daniel Pelletier, MD
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Dr. Pelletier received consulting fees from Biogen, Sanofi-Genzyme, Novartis, Hoffmann LaRoche, and Actelion.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. National Multiple Sclerosis Society

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Department of Neurology (E.M.M.), Johns Hopkins University, Baltimore, MD; Department of Neurology (C.A., D.P.), University of Southern California, Los Angeles; Department of Epidemiology and Biostatistics (C.E.M.) and MS Center (R.R.L., E.W., S.L.H.), Department of Neurology, University of California, San Francisco; and Department of Neurology (D.T.O.), University of Texas Southwestern, Dallas.
  1. Correspondence
    Dr. Mowry emowry1{at}jhmi.edu
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