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July 17, 2018; 91 (3) Article

Gray matter volume modifications in migraine

A cross-sectional and longitudinal study

Roberta Messina, Maria A. Rocca, Bruno Colombo, Elisabetta Pagani, Andrea Falini, Peter J. Goadsby, Massimo Filippi
First published June 20, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005819
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Article Information

vol. 91 no. 3 e280-e292
DOI: 
https://doi.org/10.1212/WNL.0000000000005819
PubMed: 
29925551
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received November 9, 2017
  • Accepted in final form April 16, 2018
  • First Published June 20, 2018.

Article Versions

Copyright & Usage: 
© 2018 American Academy of Neurology

Author Disclosures

    1. Roberta Messina, MD,
    2. Maria A. Rocca, MD,
    3. Bruno Colombo, MD,
    4. Elisabetta Pagani, MSc,
    5. Andrea Falini, MD, PhD,
    6. Peter J. Goadsby, MD and
    7. Massimo Filippi, MD, FEAN
  1. Roberta Messina, MD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Maria A. Rocca, MD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Serves as consultant to Biogen idec, Novartis, and ExceMed

    Speakers' Bureaus:

    1. Received speaker honoraria from Biogen Idec, Novartis, Genzyme, Sanofi-Aventis, Teva Pharmaceutical Industries and Excemed

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Italian Ministry of Health

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Fondazione Italiana Sclerosi Multipla

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Bruno Colombo, MD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Elisabetta Pagani, MSc,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. 1) ExceMED ? Excellence in Medical Education, speaker honoraria 2) ACCMED (Accademia Nazionale di Medicina),speaker honoraria 3) Biogen Idec, speaker honoraria

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Andrea Falini, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Peter J. Goadsby, MD and
    7. Scientific Advisory Boards:

    1. I have consulted for the following commercial entities Alder Bio Allergan Amgen Autonomic Technologies Inc Dr Reddy's Laboratories Eli-Lilly Electrocore LLC eNeura Inc Novartis Scion Teva Pharmaceuticals Trigemina

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal Watch Neurology Up-to-Date Massachusetts Medical Society

    Patents:

    1. NONE

    Publishing Royalties:

    1. Lance JW, Goadsby PJ. Mechanism and Management of Headache. (7th ed.) New York: Elsevier, 2005

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Amgen, Eli-Lilly

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Trigemina, Inc, stock options

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. MedicoLegal work

  7. Massimo Filippi, MD, FEAN
    8. Scientific Advisory Boards:

    1. Teva Pharmaceutical Industries

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Biogen Idec, Merck-Serono, Novartis, and Teva Pharmaceutical Industries

    Editorial Boards:

    1. Editor-in-Chief (2012-2018), Journal of Neurology

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Biogen Idec, Novartis, and Teva Pharmaceutical Industries

    Speakers' Bureaus:

    1. Biogen Idec, Merk-Serono, Novartis, and Teva Pharmaceutical Industries

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. 1) Commercial entity: Biogen-Idec 2) Commercial entity: Novartis 5) Commercial entity: Teva Pharmaceutical Industries

    Research Support, Government Entities:

    1. 1) Italian Ministry of Health; grant number: RF-2010- 2313220; role: P.I.; duration: December 2012-November 2015 2) Italian Ministry of Health; grant number: RF-2011- 02351193; role: P.I., duration: November 2014- November 2017 3) Italian Ministry of Health; grant number: RF-2011- 02350374; role: co-investigator; duration: November 2014- November 2017

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) Fondazione Italiana Sclerosi Multipla (FISM) 2) ARiSLA (Fondazione Italiana di Ricerca per la SLA) 3) Alzheimer's Drug Discovery Foundation (ADDF)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience (R.M., M.A.R., E.P., M.F.) and Departments of Neurology (R.M., M.A.R., B.C., M.F.) and Neuroradiology (A.F.), San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy; and NIHR–Wellcome Trust King's Clinical Research Facility (P.J.G.), King's College London, UK.
  1. Correspondence
    Prof. Filippi, MD, FEAN filippi.massimo{at}hsr.it
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