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March 05, 2019; 92 (10) ArticleOpen Access

Validation of an algorithm for identifying MS cases in administrative health claims datasets

William J. Culpepper, Ruth Ann Marrie, Annette Langer-Gould, Mitchell T. Wallin, Jonathan D. Campbell, Lorene M. Nelson, Wendy E. Kaye, Laurie Wagner, Helen Tremlett, Lie H. Chen, Stella Leung, Charity Evans, Shenzhen Yao, Nicholas G. LaRocca, on behalf of the United States Multiple Sclerosis Prevalence Workgroup (MSPWG)
First published February 15, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007043
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  • Figure 1
    Figure 1 Performance of algorithm MS_E-1 [(IP + OP + DMT) ≥ 3] stratified by sex across the VA, KPSC, and MB datasets

    (A) Men and women, (B) men only, and (C) women only.Data are presented as a proportion that can range between 0 and 1. DMT = disease-modifying therapy; IP = inpatient; KPSC = Kaiser Permanente Southern California; MB = Manitoba; MS = multiple sclerosis; NPV = negative predictive value; OP = outpatient; PPV = positive predictive value; VA = Department of Veterans Affairs.

  • Figure 2
    Figure 2 Performance of algorithm MS_E-1 [(IP + OP + DMT) ≥ 3] stratified by age group across the VA, KPSC, and MB datasets

    (A) Sensitivity, (B) specificity, (C) positive predictive value, (D) negative predictive value, (E) accuracy, and (F) Youden J statistic.Data from Manitoba (MB) for the 55- to 64- and 64- to 74-year age groups are suppressed due to small cell sizes. Data are presented as a proportion that can range between 0 and 1. DMT = disease-modifying therapy; IP = inpatient; KPSC = Kaiser Permanente Southern California; MS = multiple sclerosis; NPV = negative predictive value; OP = outpatient; PPV = positive predictive value; VA = Department of Veterans Affairs.

  • Figure 3
    Figure 3 Comparison of prevalence based on a 3- vs 10-year ascertainment period as of 2010 in the (A) VA and (B) MB datasets

    CI = confidence interval; MB = Manitoba; VA = Department of Veterans Affairs.

  • Figure 4
    Figure 4 Comparison of prevalence based on a 3- vs 9-year ascertainment period as of 2015 in the IMS (validation) dataset

    CI = confidence interval; IMS = Intercontinental Marketing Services.

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