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March 05, 2019; 92 (10) ArticleOpen Access

The prevalence of MS in the United States

A population-based estimate using health claims data

Mitchell T. Wallin, William J. Culpepper, Jonathan D. Campbell, Lorene M. Nelson, Annette Langer-Gould, Ruth Ann Marrie, Gary R. Cutter, Wendy E. Kaye, Laurie Wagner, Helen Tremlett, Stephen L. Buka, Piyameth Dilokthornsakul, Barbara Topol, Lie H. Chen, Nicholas G. LaRocca
First published February 15, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007035
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Figures

  • Figure 1
    Figure 1 Average annual prevalence of MS in the United States for 2008, 2009, and 2010 per 100,000 population for private (OP and TH, black lines) and government (Medicaid, Medicare, and VA, red lines) health insurance datasets

    Multiple sclerosis (MS) cases acquired from the MS algorithm in year 1 are displayed, along with new cases added cumulatively in subsequent years. OP = Optum; TH = Truven Health; VA = Department of Veterans Affairs.

  • Figure 2
    Figure 2 2010 Prevalence for MS cumulated over 10 years in the United States per 100,000 population by age and sex

    Higher and lower estimates adjusted to 2010 US Census based on combined datasets from the multiple sclerosis (MS) algorithm inclusive of the following: Truven, Optum, Department of Veterans Affairs, Medicare, and Medicaid (full data available for all age and sex estimates in data table e-7 available from Dryad, https://doi.org/10.5061/dryad.pm793v8). (A) Lower-estimate and (B) higher-estimate 2010 MS prevalence in the United States per 100,000 population.

  • Figure 3
    Figure 3 High-estimate 2010 prevalence of MS in the United States per 100,000 population (2010 US Census) by Census region with 95% CI and F:M prevalence ratio

    CI = confidence interval; F:M = female:male; MS = multiple sclerosis.

Tables

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