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Abstract
Objective To compare recognition of facial expression (FE) vs recognition of facial identity (FI) in posterior cortical atrophy (PCA), with the hypothesis that FE recognition would be relatively preserved in PCA.
Methods In this observational study, FI and expression recognition tasks were performed by 194 participants in 4 groups, including 39 with Alzheimer disease (AD) (non-PCA), 49 with behavioral variant frontotemporal dementia (bvFTD), 15 with PCA, and 91 healthy controls. Between-group differences in test scores were compared.
Results Patients with PCA performed worse than healthy controls in FI and emotion recognition tasks (p < 0.001 for all). Patients with PCA also performed worse than AD and bvFTD groups in FI recognition, with no difference in FE recognition.
Conclusions Patients with PCA have relatively preserved FE recognition compared to FI recognition, as seen in affective blindsight.
Glossary
- AD=
- Alzheimer disease;
- bvFTD=
- behavioral variant frontotemporal dementia;
- CATS=
- Comprehensive Affect Testing System;
- CI=
- confidence interval;
- HC=
- healthy controls;
- MAC=
- Memory and Aging Center;
- MMSE=
- Mini-Mental State Examination;
- MNI=
- Montreal Neurological Institute;
- PCA=
- posterior cortical atrophy;
- UCSF=
- University of California, San Francisco;
- V1=
- primary visual cortex;
- VBM=
- voxel-based morphometry
Footnotes
Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.
- Received January 29, 2018.
- Accepted in final form October 26, 2018.
- © 2019 American Academy of Neurology
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