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March 05, 2019; 92 (10) Article

Somatosensory system integrity explains differences in treatment response after stroke

Morgan L. Ingemanson, Justin R. Rowe, Vicky Chan, Eric T. Wolbrecht, David J. Reinkensmeyer, Steven C. Cramer
First published February 6, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007041
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Article Information

vol. 92 no. 10 e1098-e1108
DOI: 
https://doi.org/10.1212/WNL.0000000000007041
PubMed: 
30728310
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received July 11, 2018
  • Accepted in final form October 31, 2018
  • First Published February 6, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Morgan L. Ingemanson, PhD,
    2. Justin R. Rowe, PhD,
    3. Vicky Chan, MSPT,
    4. Eric T. Wolbrecht, PhD,
    5. David J. Reinkensmeyer, PhD and
    6. Steven C. Cramer, MD
  1. Morgan L. Ingemanson, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Justin R. Rowe, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. (1) Flint Rehabilitation Devices, LLC, Design Engineer, 3 years

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Vicky Chan, MSPT,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Eric T. Wolbrecht, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Edwards, Dean B. (PI), Anderson, Michael J. (CO-PI), Canning, Roger (CO-PI), , Wolbrecht, Eric (Co-PI), Frenzel, James (CO-PI), Soule, Terence (CO-PI), ?Configurable UUV Sensor Network?, sponsored by Office of Naval Research (N00014-16-1-3013), $1.838,547.00. (January 1, 2017 ? December 31st, 2019). Edwards, Dean B. (PI), Anderson, Michael J. (CO-PI), Canning, Roger (CO-PI), , Wolbrecht, Eric (Co-PI), Frenzel, James (CO-PI), Soule, Terence (CO-PI), ?Configurable UUV Sensor Network?, sponsored by Office of Naval Research (N00014-16-1-3013), $147,999.99. (March 1, 2016 ? December 31st, 2016). Edwards, Dean B. (PI), Anderson, Michael J. (CO-PI), Frenzel, James (CO-PI), Soule, Terence (CO-PI), Wolbrecht, Eric (Co-PI), ?Configurable UUV Sensor Network?, sponsored by Office of Naval Research (N00014-14-1-0662), $564,766.00. (May 5, 2014 ? April 31st, 2016).

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. David J. Reinkensmeyer, PhD and
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editor-in-Chief, Journal of Neuroengineering and Rehabilitation, 2015-current

    Patents:

    1. NONE

    Publishing Royalties:

    1. Neurorehabilitation Technology, Springer, 2017

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant to Flint Rehabilitation Devices, LLC

    Speakers' Bureaus:

    1. NONE

    Other activities:

    1. Founder and member of the Board of Directors, Flint Rehabilitation Devices

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Flint Rehabilitation Devices, NIH Small Business Innovation Research Grant, subcontract to UCI

    Research Support, Government Entities:

    1. NIH-R01HD062744-01

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. Flint Rehabilitation Devices. Hocoma A.G.

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. Royalty for arm exoskeleton invention, paid by Hocoma AG to UC Irvine

    Stock/Stock Options, Research Sponsor:

    1. Flint Rehabilitation Devices Stock/Stock Options, Medical Equipment & Materials: Hocoma AG

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Steven C. Cramer, MD
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Neurorehab and Neural Repair, Editorial Board

    Patents:

    1. A US patent is pending for a telerehabilitation device. This device provides post-stroke rehabilitation therapy in a home-based setting.

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Dr. Cramer is a consultant for MicroTransponder, Dart Neuroscience, Neurolutions, Regenera, Abbvie, SanBi, and TRCare.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. (1) American Heart Association, (2) Medtronics, and (3) SanBio.

    Research Support, Government Entities:

    1. National Institutes of Health 9/13-8/18 Principal Investigator, K24 HD074722, ?Brain plasticity and rehabilitation after stroke? 10/13-9/18 co-Principal Investigator, U01 NS086872, ?National Stroke Trial Network National Clinical Coordinating Center? (Joe Broderick overall PI) 9/14-7/18 Principal Investigator, U01 NS091951, ?Telerehabilitation for Patients with Stroke? 9/15-8/20 Principal Investigator (with E. Alison Holman, multiple PI), R01 NR015591, ?Genetic variation, stress, and functional outcomes after stroke rehabilitation? 8/15 - 3/19 sub-investigator, UL1 TR001414, ?Institute for Clinical And Translational Science? (Dan Cooper overall PI) 9/15-8/16 Site Principal Investigator, R44 HD082882, ?Lever actuated rehabilitation of the arm using wheelchair propulsion and computer gaming? (Danny Zondervan, overall PI) Calif. Inst. for Regenerative Medicine 4/15-3/20 co- Principal Investigator, AC1-07675, ?UCLA ? UC Irvine Alpha Stem Cell Consortium? (John Adams, UCLA, PI)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. TRCare

    License fee payments, Technology or Inventions:

    1. University of California, for stroke training and treatment technology

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Departments of Anatomy and Neurobiology (M.L.I., D.J.R., S.C.C.), Biomedical Engineering (J.R.R., D.J.R.), Neurology (V.C. , S.C.C.), Mechanical and Aerospace Engineering (D.J.R.), and Physical Medicine and Rehabilitation (D.J.R. , S.C.C.), University of California at Irvine; and Department of Mechanical Engineering (E.T.W.), University of Idaho, Moscow.
  1. Correspondence
    Dr. Cramer scramer{at}uci.edu
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