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March 26, 2019; 92 (13) Article

Levodopa-induced dyskinesia is closely linked to progression of frontal dysfunction in PD

View ORCID ProfileHan Soo Yoo, Seok Jong Chung, Yang Hyun Lee, Hye Sun Lee, Byoung Seok Ye, Young H. Sohn, Phil Hyu Lee
First published February 22, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007189
Han Soo Yoo
From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
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  • ORCID record for Han Soo Yoo
Seok Jong Chung
From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
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Yang Hyun Lee
From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
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Hye Sun Lee
From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
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Byoung Seok Ye
From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
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Young H. Sohn
From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
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Phil Hyu Lee
From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
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Levodopa-induced dyskinesia is closely linked to progression of frontal dysfunction in PD
Han Soo Yoo, Seok Jong Chung, Yang Hyun Lee, Hye Sun Lee, Byoung Seok Ye, Young H. Sohn, Phil Hyu Lee
Neurology Mar 2019, 92 (13) e1468-e1478; DOI: 10.1212/WNL.0000000000007189

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Article Information

vol. 92 no. 13 e1468-e1478
DOI: 
https://doi.org/10.1212/WNL.0000000000007189
PubMed: 
30796137

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received August 30, 2018
  • Accepted in final form November 21, 2018
  • First Published February 22, 2019.

Article Versions

  • Previous version (February 22, 2019 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Han Soo Yoo, MD,
    2. Seok Jong Chung, MD,
    3. Yang Hyun Lee, MD,
    4. Hye Sun Lee, PhD,
    5. Byoung Seok Ye, MD, PhD,
    6. Young H. Sohn, MD, PhD and
    7. Phil Hyu Lee, MD, PhD
  1. Han Soo Yoo, MD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Seok Jong Chung, MD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant number: NRF- 2018R1D1A1B07048959).

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Yang Hyun Lee, MD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Hye Sun Lee, PhD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Byoung Seok Ye, MD, PhD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Young H. Sohn, MD, PhD and
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Samil Pharmaceuticals, funding for travel to conference (2) Glaxo-Smith-Klein Korea, funding for travel to conference (3) Eisai Korea, funding for travel to conference (4) Novartis Korea, funding for travel to conference (5) Lundbeck Korea, funding for travel to conference

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Phil Hyu Lee, MD, PhD
  14. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI14C0093).

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology (H.S.Y., S.J.C., Y.H.L., B.S.Y., Y.H.S., P.H.L.), Severance Biomedical Science Institute (P.H.L.), and Biostatistics Collaboration Unit (H.S.L), Yonsei University College of Medicine, Seoul, South Korea.
  1. Correspondence
    Dr. Lee phee{at}yuhs.ac
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Online ISSN:1526-632X

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