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April 02, 2019; 92 (14) Article

Dietary patterns during adulthood and cognitive performance in midlife

The CARDIA study

Claire T. McEvoy, Tina Hoang, Stephen Sidney, Lyn M. Steffen, David R. Jacobs, James M. Shikany, John T. Wilkins, Kristine Yaffe
First published March 6, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007243
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Article Information

vol. 92 no. 14 e1589-e1599
DOI: 
https://doi.org/10.1212/WNL.0000000000007243
PubMed: 
30842290
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received April 13, 2018
  • Accepted in final form November 28, 2018
  • First Published March 6, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Claire T. McEvoy, PhD,
    2. Tina Hoang, MSPH,
    3. Stephen Sidney, MD,
    4. Lyn M. Steffen, PhD,
    5. David R. Jacobs Jr, PhD,
    6. James M. Shikany, DrPH,
    7. John T. Wilkins, MD and
    8. Kristine Yaffe, MD
  1. Claire T. McEvoy, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Dr McEvoy is supported by a Beeson-CARDI Fellowship from the American Federation of Aging Research. Grant Ref LP3-04

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Tina Hoang, MSPH,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Stephen Sidney, MD,
    4. Scientific Advisory Boards:

    1. All Non-Profit Entities: (1) National Forum for Heart Disease and Stroke Prevention (2) GRADE DSMB

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. All Non-Profit Entities: (1) National Forum for Heart Disease and Stroke Prevention (2) GRADE DSMB

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. The Permanente Medical Group, Senior Research Scientist and Director of Research Clinics. 35 years in research scientist position

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Funded as principal investigator on NHLBI Contract N01 HC-48050 12/30/83-6/30/18; Funded as principal investigator on NINDS U54NS081760 10/1/12-9/30/17; Funded as co-investigator on NINDS U54NS081760 10/1/12-9/30/17; Funded as principal investigator on 1R01HL122658 12/1/2014-11/30/2018; Funded as co-investigator on NIDDK/ GHRI R01DK092317 10/1/12-9/30/16.

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Lyn M. Steffen, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Current Nutrition Reports (Springer); section editor for 3 years (2014-2017)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. research grant funding: California Walnut Commission research grant funding: Dairy Management

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. grant funding from NIH/NHLBI

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. David R. Jacobs Jr, PhD,
    6. Scientific Advisory Boards:

    1. 1) Scientific Advisory Board, California Walnut Commission

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Clinical Chemistry, long term, Editorial advisory board member Circulation, long term, Statistical reviewer JAHA, long term, Statistical reviewer

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant, California Walnut Commission

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Multiple (usually >10) R01 grants and contracts from the National Institutes of Health

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. James M. Shikany, DrPH,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. Title: Science Dialogue Mapping of Knowledge and Knowledge Gaps Related to the Effects of Dairy Intake on Human Health Principal Investigator: David B. Allison, PhD Role: Investigator Period of funding: 06/01/2016-03/31/2018 Total costs: $251,062 Source: Dairy Management, Inc. Title: Science Dialogue Mapping of Knowledge and Knowledge Gaps Related to the Effects of Dairy Intake on Human Health Principal Investigator: David B. Allison, PhD Role: Investigator Period of funding: 06/01/2016-03/31/2018 Total costs: $251,062 Source: Dairy Management, Inc. Title: Heart Failure with Preserved EF: Female Sex Hormones and Cyclic GMP-PKG Modulation of Cardiac Disease and Metabolism Principal Investigator: Wendy Post, MD Role: Principal Investigator of UAB subcontract Period of funding: 02/01/2017-01/31/2018 Total costs: $6,155 Source American Heart Association/Johns Hopkins University (UAB Subcontract)

    Research Support, Government Entities:

    1. Title: Coronary Artery Risk Development in Young Adults ? Coordinating Center Principal Investigator: James M. Shikany, DrPH Period of funding: 07/01/2018-06/31/2023 Total costs: $13,810,098 Source: NIH (NHLBI) Title: Osteoporotic Fractures in Men (MrOS) Renewal ? Birmingham Principal Investigator: James M. Shikany, DrPH Period of funding: 08/01/2013-04/30/2019 Total costs: $2,633,235 Source: NIH (NIAMS) Title: National Transdisciplinary Collaborative Center for Research on African American Men?s Health Principal Investigator: James M. Shikany, DrPH Period of funding: 07/01/2013-06/30/2019 Total costs: $2,674,163 Source: NIH (NIMHD) Title: Molecular Markers of Early Cardiometabolic Health Transitions in the CARDIA Study Principal Investigator: Role: Principal Investigator of UAB subcontract Period of funding: 04/01/2017-02/28/2022 Total costs: $53,626 Source: NIH (NHLBI)/Harvard University (UAB subcontract) Title: Dairy Consumption, Dietary Patterns and Cardiac Phenotypes Principal Investigator: Lyn Steffen, PhD Role: Principal Investigator of UAB subcontract Period of funding: 06/01/2017-02/28/2019 Total costs: $53,555 Source: NIH (NHLBI)/University of Minnesota (UAB subcontract) Title: Caloric and Non-caloric Sweeteners and the Distribution of Adipose Tissue Principal Investigator: Lyn Steffen, PhD Role: Principal Investigator of UAB subcontract Period of funding: 01/01/2017-12/31/2018 Total costs: $46,767 Source: NIH (NHLBI)/University of Minnesota (UAB subcontract) Title: Lung Function Decline and Disease Risk from Young Adulthood to Middle Age Principal Investigator: Ravi Kalhan, MD Role: Co-Principal Investigator of UAB subcontract Period of funding: 08/01/2014-07/31/2019 Total costs: $210,683 Source: NIH (NHLBI)/Northwestern University (UAB subcontract) Title: Pregnancy-Related Risk Factors and Glucose Tolerance in Women during Midlife Principal Investigator: Erica Gunderson, PhD Role: Principal Investigator of UAB subcontract Period of funding: 08/27/2015-07/31/2019 Total costs: $221,565 Source: NIH (NHLBI)/Kaiser Permanente (UAB subcontract) Title: Determinants of Midlife & Longitudinal Change in Cognitive Function: CARDIA Study Principal Investigators: Steve Sidney, MD and Kristine Yaffe, MD Role: Principal Investigator of UAB subcontract Period of funding: 12/01/2014-11/30/2018 Total costs: $177,486 Source: NIH/Kaiser Permanente (UAB subcontract) Title: Transdisciplinary Collaborative Center (TCC) for Colorectal Cancer Research Principal Investigator: Mona N. Fouad, MD Role: Investigator Period of funding: 07/01/2016-06/30/2019 Total costs: $399,956 Source: National Academy of Sciences Title: Diabetes Research Center Principal Investigator: Timothy W. Garvey, MD Role: Investigator Period of funding: 03/01/2013-02/28/2019 Total costs: $1,076,289 Source: NIH (NIDDK) Title: Collaboration to Improve Blood Pressure in the US Black Belt ? Addressing the Triple Threat Principal Investigator: Andrea Cherrington, MD Role: Investigator Period of Funding: 09/15/2016-08/31/2020 Total costs: $8,450,038 Source: NIH (NHLBI)/Weill Cornell University (UAB subcontract) Title: Trajectory of Anti-Mullerian Hormone Decline and CVD Risk in CARDIA Women Principal Investigator: Melissa Wellons, MD Role: Principal Investigator of UAB subcontract Period of funding: 09/01/2016-08/31/2018 Total costs: $17,671 Source NIH (NHLBI)/Vanderbilt University (UAB Subcontract) Title: Trans-Omics for Precision Medicine (TOPMed) Data Coordinating Center (DCC) Principal Investigator: James M. Shikany, DrPH Period of funding: 03/01/2018-08/31/2018 Total costs: $30,000 Source: NIH/University of Washington Title: Biomarker Associations with Cerebral Structure and Function in a Young-to-Middle Age Cohort: CARDIA Brain MRI Sub-Study Principal Investigator: James M. Shikany, DrPH Period of funding: 11/01/2014-10/31/2017 Total costs: $1,163,869 Source: NIH (NHLBI) Title: The Role of Plasminogen Activator Inhibitor-1 in the Development and Progression of Obesity Principal Investigator: Sadiya Khan, MD Role: Principal Investigator of UAB subcontract Period of funding: 08/01/2015-07/31/2017 Total costs: $17,784 Source: NIH/Northwestern University (UAB subcontract) Title: Determination of Skeletal Muscle Mass by Creatine Dilution Principal Investigator: Peggy Cawthon, PhD Role: Principal Investigator of UAB subcontract Period of funding: 09/01/2013-08/31/2017 Total costs: $79,646 Source: NIH (NIAMS)/California Pacific Medical Center (UAB subcontract) Title: Reasons for Geographic and Racial Disparities in Stroke ? Myocardial Infarction Study ? 2 (REGARDS-MI-2) Role: Principal Investigator Period of funding: 04/01/2005-01/31/2017 Total costs: $3,710,904 Source: NIH (NHLBI)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. John T. Wilkins, MD and
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NMG Biopharmaceuticals

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NHLBI LRP (Recipient) NHLBI K23 HL133601 (PI)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Kristine Yaffe, MD
    9. Scientific Advisory Boards:

    1. 1)DSMB for Takeda, Inc 2)DSMBs for NIH sponsored study 3)Beeson Scientific Advisory Board 4)DZNE Senate Member

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. -Associate Editor, 2011-, International Review of Psychiatry -Associate Editor 2012-16, Journal of Gerontology: Medical Sciences -Editorial Board Member 2014-, Journal of Prevention of Alzheimer?s Disease - Editorial Board Member 2017-, Alzheimer?s & Dementia: Translational Research & Clinical Interventions

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. R01 AG026720 (Multiple PI: Yaffe and Stone) NIA Change in Sleep & Cognition in Older Women 07/06-03/19 2. K24 AG031155 (PI) NIA Predictors of cognitive aging across the lifecourse 06/13-11/20 3. P50 AG023501 (PI) NIA Alzheimer?s Disease Research Centers: Data and Statistical Core 04/14-03/19 4. Director Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center Psychiatric Fellowship 10/09-09/23 5. R01 AG05407 (Multiple PI: Yaffe and Cummings) NIA Study of Osteoporotic Fractures: Successful Aging 09/11-05/18 6. PI of Dementia Research at SF VA Medical Center Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center 10/09-09/23 7. R01 MD007019 (Co-investigator, PI: Byers) NIH: National Institute on Minority Health and Health Disparities Epidemiology of Suicidal Behavior in Racially/Ethnically Diverse Older Americans 04/12-10/17 8. P30 AG044281 (Co-Investigator, PI: Covinsky) NIA UCSF Older American Independence Center 07/13-06/18 9. (Co-Investigator, PI: Cifu) Department of Defense/VA Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 07/13-09/18 10. W81XWH-14-2-0137 (PI: Yaffe) Department of Defense Blood biomarker profile of TBI-associated cognitive impairment among old & young veterans 10/14-09/18 11. W81XWH-14-2-0176 (Co-Investigator, PI: Manley) Department of Defense Traumatic Brain Injury Endpoints Development (TED) Award 10/14-09/19 12. R01 HL122658 (Multiple PI: Yaffe and Sidney) NHLBI Determinants of Midlife & Longitudinal Change in Cognitive Function 12/14-11/18 13. W81XWH-12-PHTBI-CENC (PI: Yaffe) Department of Defense/VA Epidemiology Project. Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 02/15-09/18 14. R01 AG048234 (Co-investigator, PI: Kramer) NIA Effects of Chronic Inflammation on Brain Structure and Function 04/15-01/20 15. R01 AG032289 (Co-investigator, PI: Kramer) NIA Biological predictors of brain aging trajectories 09/15-05/20 16. W81XWH-14-1-0467 (Co-investigator, PI: Sierks) Department of Defense Oligomeric Protein Variants as Biomarkers for AD and TBI Susceptibility 09/15-09/17 17. R01 AG052964 (Co-investigator, PI: Cummings) NIA Comprehensive Evaluation of Aging-Related Clinical Outcomes and Geroproteins 06/16-05/21 18. RF1 G050745 (Co-investigator, PI: Spira) NIA The ARIC study of midlife sleep and late-life brain amyloid 06/16-05/21 19. UL1 TR991872 (Director of Pilot Grants Program, PI: Grandis) National Center for Advancing Translational Sciences Clinical and Translational Science Institute 07/16-06/21 20. W81XWH-16-1-0507 (PI: Yaffe) Department of Defense Risk and Resiliency for Dementia: Comparison of Male and Female Veterans 08/16-08/19 21. RF1 AG054443 (Multiple PI: Yaffe and Zeki-Al Hazzouri) NIA Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment 05/17-04/21 22. R01 AG054073 (Multiple PI: Yaffe/O?Bryant/Toga) NIA Health Disparities in Alzheimer?s Disease and Mild Cognitive Impairment among Mexican Americans 09/17-05/22 23. R01 AG057508 (Multiple PI: Yaffe/Larson) NIA Systematic Multi-Domain Alzheimer?s Risk Reduction Trial 09/17-05/21 24. R01 AG058537 (Multiple PI: Yaffe/O?Bryant) NIA An Alzheimer?s Blood Test for Primary Care 6/18-5/21

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1)Doris Duke Charitable Foundation Doris Duke Fund to Retain Clinical Scientists 2) Alzheimer?s Drug Discovery Foundation Connection Between Depressive Symptoms and Dementia:When Best to Intervene?

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the Centre for Public Health (C.T.M.), School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland, UK; Global Brain Health Institute (C.T.M., K.Y.), Department of Neurology (K.Y.), and Department of Epidemiology and Biostatistics (K.Y.), University of California, San Francisco; Trinity College Dublin (C.T.M.), Ireland; Northern California Institute for Research and Education (T.H.), San Francisco; Division of Research (S.S.), Kaiser Permanente Northern California, Oakland; Division of Epidemiology and Community Health (L.M.S., D.R.J.), School of Public Health, University of Minnesota, Minneapolis; Division of Preventive Medicine (J.M.S.), School of Medicine, University of Alabama at Birmingham; Department of Preventive Medicine and Medicine (Cardiology) (J.T.W.), Northwestern University Feinberg School of Medicine, Chicago, IL; and San Francisco Veterans Affairs Medical Center (K.Y.), CA.
  1. Correspondence
    Dr. McEvoy c.mcevoy{at}qub.ac.uk
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