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April 02, 2019; 92 (14) Resident & Fellow Section

Teaching NeuroImages: In vivo visualization of Edinger comb and Wilson pencils

Andreas Horn, Siobhán Ewert, Eduardo J.L. Alho, Markus Axer, Helmut Heinsen, Erich T. Fonoff, Jonathan R. Polimeni, Todd M. Herrington
First published April 1, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007252
Andreas Horn
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Siobhán Ewert
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Eduardo J.L. Alho
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Markus Axer
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Helmut Heinsen
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Erich T. Fonoff
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Jonathan R. Polimeni
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Todd M. Herrington
From the Department of Neurology, Neuromodulation and Movement Disorders Unit (A.H., S.E.), Charité–University Medicine (CCM), Berlin, Germany; Department of Neurology (S.E., T.M.H.) and Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (J.R.P.), Massachusetts General Hospital, and Department of Radiology (J.R.P.), Harvard Medical School, Boston; Department of Neurology (E.J.L.A., E.T.F.), University of São Paulo Medical School, Brazil; Institute of Neuroscience and Medicine (INM-1) (M.A.), Forschungszentrum Jülich GmbH; and Morphological Brain Research Unit, Department of Psychiatry (H.H.), University of Würzburg, Germany.
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Citation
Teaching NeuroImages: In vivo visualization of Edinger comb and Wilson pencils
Andreas Horn, Siobhán Ewert, Eduardo J.L. Alho, Markus Axer, Helmut Heinsen, Erich T. Fonoff, Jonathan R. Polimeni, Todd M. Herrington
Neurology Apr 2019, 92 (14) e1663-e1664; DOI: 10.1212/WNL.0000000000007252

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The “direct” and “indirect” pathways play crucial roles in movement disorder pathophysiology. Both traverse from the striatum to the internal pallidum and substantia nigra, the latter detouring to external pallidum and subthalamic nucleus. Anatomically, the pathways manifest within the striatofugal bundle that passes radially through the pallidum in the form of pencil-like tracts (first described by Wilson1; figure 1) before leaving the pallidum toward the substantia nigra in the form of a comb described by Edinger in 18962 (figure 2). A century later, these structures can be visualized in the living human brain (figures 1D and 2A).

Figure 1
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Figure 1 Wilson pencils

(A) Histologic depiction (image courtesy of Dr. Michael Bonert, McMaster University, CCBY-SA3.0). (B) Polarized light imaging in vervet monkey. (C) First description by Wilson (Brain), reproduced with permission from S.A. Kinnier Wilson. An experimental research into the anatomy and physiology of the corpus striatum. Brain 1914;36:427–492. By permission of Oxford University Press, available at: academic.oup.com/brain/article/36/3-4/427/309802?searchresult=1. For permissions, please email journals.permissions{at}oup.com. (D) Cardiac-gated T2*-weighted fast low angle shot sequence acquired using 7T MRI shows Wilson pencils.

Figure 2
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Figure 2 Edinger comb

(A) Cardiac-gated fast low angle shot sequence shows Edinger comb. (B) First description: “The pedunculus cerebri is traversed by striatal fibers that enter dorsally and connect peduncle and tegmentum—bundle between peduncle and tegmentum, comb system of the peduncle.” (C) Axial histologic section in dark-field microscopy demonstrates the human comb system.

Author contributions

A. Horn: drafting/revising the manuscript, data acquisition, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data, study supervision. Siobhan G. Ewert: drafting/revising the manuscript, data acquisition, accepts responsibility for conduct of research and final approval, acquisition of data. Eduardo Joaquim Lopes Alho: drafting/revising the manuscript, accepts responsibility for conduct of research and final approval, acquisition and analysis of the dark field microscopy footage. M. Axer: data acquisition, accepts responsibility for conduct of research and final approval, acquisition of data, interpretation of measurements. H. Heinsen: drafting/revising the manuscript, data acquisition, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data. Erich Talamoni Fonoff: drafting/revising the manuscript, data acquisition, accepts responsibility for conduct of research and final approval, acquisition of data. J.R. Polimeni: drafting/revising the manuscript, data acquisition, accepts responsibility for conduct of research and final approval, acquisition of data, study supervision, obtaining funding. T.M. Herrington: data acquisition, drafting/revising the manuscript, study concept or design, accepts responsibility for conduct of research and final approval, study supervision.

Study funding

No targeted funding reported.

Disclosure

A. Horn, S. Ewert, E. Alho, M. Axer, H. Heinsen, and E. Fonoff report no disclosures relevant to the manuscript. J. Polimeni reports funding by NIH NIMH R01-MH111438 and NIBIB P41-EB015896 and by the Athinoula A. Martinos Center for Biomedical Imaging. T. Herrington reports funding by NINDS grant K23NS099380 and an American Academy of Neurology/American Brain Foundation Clinical Research Training Fellowship. Go to Neurology.org/N for full disclosures.

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Teaching slides links.lww.com/WNL/A850

  • © 2019 American Academy of Neurology

References

  1. 1.↵
    1. Wilson SAK
    . An experimental research into the anatomy and physiology of the corpus striatum. Brain 1914;36:427–492.
    OpenUrlCrossRef
  2. 2.↵
    1. Edinger L
    . Vorlesungen über den Bau der nervösen Centralorgane des Menschen und der Thiere. Für Ärzte und Studirende. Leipzig: F.C.W. Vogel; 1896.

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