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April 09, 2019; 92 (15 Supplement) May 6, 2019

ENIGMA Military Brain Injury: Altered Subcortical Volume in Chronic TBI Revealed by Mega-Analysis (P2.9-061)

Emily Dennis, Elisabeth Wilde, Artemis Zavaliangos-Petropulu, Mary Newsome, Randall Scheibel, Maya Troyanskaya, Carmen Velez, Benjamin Wade, Ann Marie Drennon, Gerald York, Erin Bigler, Tracy Abildskov, Brian Taylor, Carlos Jaramillo, Blessen Eapen, Heather Belanger, Rajendra Morey, Courtney Haswell, Heather Bouchard, Maheen Adamson, Xiaojian Kang, Inga Koerte, Martha Shenton, Harvey Levin, Sidney Hinds, William Walker, Paul Thompson, David Tate
First published April 16, 2019,
Emily Dennis
1Brigham and Women’s Hospital, Harvard Medical School Mountain View CA United States
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Elisabeth Wilde
2University of Utah Salt Lake City UT United States
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Artemis Zavaliangos-Petropulu
3Imaging Genetics Center, SNII, Keck SOM Marina del Rey CA United States
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Mary Newsome
4Baylor College of Medicine Houston TX United States
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Randall Scheibel
4Baylor College of Medicine Houston TX United States
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Maya Troyanskaya
4Baylor College of Medicine Houston TX United States
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Carmen Velez
5Missouri Institute of Mental Health St Louis MO United States
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Benjamin Wade
5Missouri Institute of Mental Health St Louis MO United States
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Ann Marie Drennon
6DVBIC San Antonio San Antonio TX United States
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Gerald York
7Alaska Radiology Associates Anchorage AK United States
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Erin Bigler
8Brigham Young University Provo UT United States
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Tracy Abildskov
8Brigham Young University Provo UT United States
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Brian Taylor
9Department of Biomedical Engineering, Virginia Commonwealth University Richmond VA United States
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Carlos Jaramillo
10Polytrauma Rehabilitation Center, South Texas Veterans Health Care System San Antonio TX United States
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Blessen Eapen
11VA Greater Los Angeles Los Angeles CA United States
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Heather Belanger
12James A. Haley Veterans Hospital Tampa FL United States
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Rajendra Morey
13Duke University Durham NC United States
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Courtney Haswell
13Duke University Durham NC United States
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Heather Bouchard
13Duke University Durham NC United States
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Maheen Adamson
14DVBIC Palo Alto Palo Alto CA United States
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Xiaojian Kang
14DVBIC Palo Alto Palo Alto CA United States
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Inga Koerte
1Brigham and Women’s Hospital, Harvard Medical School Mountain View CA United States
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Martha Shenton
1Brigham and Women’s Hospital, Harvard Medical School Mountain View CA United States
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Harvey Levin
4Baylor College of Medicine Houston TX United States
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Sidney Hinds
15Department of Defense/United States Army Medical Research and Materiel Command FT Detrick MD United States
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William Walker
16Department of Physical Medicine & Rehabilitation, Virginia Commonwealth University Richmond VA United States
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Paul Thompson
3Imaging Genetics Center, SNII, Keck SOM Marina del Rey CA United States
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David Tate
5Missouri Institute of Mental Health St Louis MO United States
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Citation
ENIGMA Military Brain Injury: Altered Subcortical Volume in Chronic TBI Revealed by Mega-Analysis (P2.9-061)
Emily Dennis, Elisabeth Wilde, Artemis Zavaliangos-Petropulu, Mary Newsome, Randall Scheibel, Maya Troyanskaya, Carmen Velez, Benjamin Wade, Ann Marie Drennon, Gerald York, Erin Bigler, Tracy Abildskov, Brian Taylor, Carlos Jaramillo, Blessen Eapen, Heather Belanger, Rajendra Morey, Courtney Haswell, Heather Bouchard, Maheen Adamson, Xiaojian Kang, Inga Koerte, Martha Shenton, Harvey Levin, Sidney Hinds, William Walker, Paul Thompson, David Tate
Neurology Apr 2019, 92 (15 Supplement) P2.9-061;

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Abstract

Objective: To identify alterations in subcortical gray matter (GM) volume in Active Duty Service Members (ADSM) and Veterans of the United States military with history of traumatic brain injury (TBI), with greater power from multi-site mega-analysis.

Background: TBI is one of the most common injuries affecting armed service members across the world. Injuries can affect combat readiness and can lead to long-term cognitive impairments and adverse health consequences. Altered subcortical GM volume may contribute to poor outcome. Reliable neuroimaging biomarkers of TBI have been elusive, often due to small sample size.

Design/Methods: Participants were assessed through three different projects – DoD Alzheimer’s Disease Neuroimaging Initiative, Imaging Support of Study of Cognitive Rehabilitation Effectiveness in Mild Traumatic Brain Injury, and Chronic Effects of Neurotrauma Consortium, totaling 199 participants reporting at least one TBI (178M/21F) and 170 participants without history of TBI (153M/17F). Participants were between 18–83 years old. T1-weighted MR images were processed using FreeSurfer v5.3 and volume estimates of the thalamus, caudate, putamen, hippocampus, amygdala, nucleus accumbens, globus pallidus, and lateral ventricles were extracted using a standard protocol (http://enigma.usc.edu). TBI versus control effect sizes were calculated across sites using random effects to control for site effects, including age, sex, education, and intracranial volume as covariates.

Results: We found significantly smaller left thalamic volume in the TBI group (t(367)=−3.0, p=0.0025). Within female participants (21 TBI/17 controls), those with TBI showed a larger putamen (t(36)=2.3, p=0.03). There was a sex-by-diagnosis effect in the left and right thalamus (left t(367)=2.8, p=0.0054; right t(367)=2.7, p=0.0066).

Conclusions: We report reduced thalamic volume in Veterans and ADSM with history of TBI. Altered thalamic volume may contribute to motor, cognitive and other symptoms post-injury. Future studies on a larger sample need to verify a potential effect of sex. Future work will also examine associations of subcortical GM volume with clinical outcome measures.

Disclosure: Dr. Dennis has nothing to disclose. Dr. Wilde has nothing to disclose. Dr. Zavaliangos-Petropulu has nothing to disclose. Dr. Newsome has nothing to disclose. Dr. Scheibel has nothing to disclose. Dr. Troyanskaya has nothing to disclose. Dr. Velez has nothing to disclose. Dr. Wade has nothing to disclose. Dr. Drennon has nothing to disclose. Dr. York has nothing to disclose. Dr. Bigler has nothing to disclose. Dr. Abildskov has nothing to disclose. Dr. Taylor has nothing to disclose. Dr. Jaramillo has nothing to disclose. Dr. Eapen has nothing to disclose. Dr. Belanger has nothing to disclose. Dr. Morey has nothing to disclose. Dr. Haswell has nothing to disclose. Dr. Bouchard has nothing to disclose. Dr. Adamson has nothing to disclose. Dr. Kang has nothing to disclose. Dr. Koerte has nothing to disclose. Dr. Shenton has nothing to disclose. Dr. Levin has nothing to disclose. Dr. Hinds has nothing to disclose. Dr. Walker has nothing to disclose. Dr. Thompson has nothing to disclose. Dr. Tate has nothing to disclose.

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