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April 09, 2019; 92 (15 Supplement) May 7, 2019

Infection and Parkinson’s Disease: a Systematic Review and Meta-analysis (P3.8-047)

Muhammed Khaled Elfaituri, Sherief Ghozy, Eman El-Sayed Sakr, Salma Said Elkolaly, Mohamed Magdy Khattab, Mariam Abdelmageed Mahmoud, Mariam Abdelmageed Mahmoud, Samar Muhammad Mehyar, Mansour Antar Alhattab, Ahmed Mahmoud Ahmed Ismail, Mohamed Abdelmongy, Mostafa Mahmoud Fahmy, Esraa Mamdouh Gharib, Asma Hallab, Mostafa Ebraheem Morra, Kenji Hirayama, Nguyen Tien Huy
First published April 16, 2019,
Muhammed Khaled Elfaituri
1Faculty of Medicine, University of Tripoli Tripoli Egypt
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Sherief Ghozy
2Neurosurgery Departement, El Sheikh zayed specialized hospital Giza Egypt
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Eman El-Sayed Sakr
3Faculty of Medicine, Menoufia University Menoufia, Egypt
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Salma Said Elkolaly
3Faculty of Medicine, Menoufia University Menoufia, Egypt
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Mohamed Magdy Khattab
4Faculty of Medicine, Al-Azhar University Cairo Egypt
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Mariam Abdelmageed Mahmoud
5Faculty of Medicine, Tanta University Cairo Egypt
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Mariam Abdelmageed Mahmoud
5Faculty of Medicine, Tanta University Cairo Egypt
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Samar Muhammad Mehyar
6Al istishari hospita Amman Jordan
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Mansour Antar Alhattab
7Faculty of Medicine, Alexandria University Alexandria Egypt
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Ahmed Mahmoud Ahmed Ismail
8Faculty of Medicine, Minia University Minia Egypt
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Mohamed Abdelmongy
9Faculty of Medicine, Misr University for Science & Technology 6th of October City Egypt
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Mostafa Mahmoud Fahmy
5Faculty of Medicine, Tanta University Cairo Egypt
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Esraa Mamdouh Gharib
10Faculty of Medicine, October 6 university 6th of October City Egypt
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Asma Hallab
11Psychiatry department, Johanniter Hospital Brandenburg Treuenbrietzen Germany
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Mostafa Ebraheem Morra
4Faculty of Medicine, Al-Azhar University Cairo Egypt
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Kenji Hirayama
12Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences Nagasaki Japan
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Nguyen Tien Huy
13Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University Nagasaki Japan
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Citation
Infection and Parkinson’s Disease: a Systematic Review and Meta-analysis (P3.8-047)
Muhammed Khaled Elfaituri, Sherief Ghozy, Eman El-Sayed Sakr, Salma Said Elkolaly, Mohamed Magdy Khattab, Mariam Abdelmageed Mahmoud, Mariam Abdelmageed Mahmoud, Samar Muhammad Mehyar, Mansour Antar Alhattab, Ahmed Mahmoud Ahmed Ismail, Mohamed Abdelmongy, Mostafa Mahmoud Fahmy, Esraa Mamdouh Gharib, Asma Hallab, Mostafa Ebraheem Morra, Kenji Hirayama, Nguyen Tien Huy
Neurology Apr 2019, 92 (15 Supplement) P3.8-047;

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Abstract

Objective: Therefore, we conducted a meta-analysis to quantitatively assess the association of several infectious diseases with the risk of PD.

Background: Parkinson Disease (PD) is a progressive age-related neurodegenerative disorder that presents with tremors, cogwheel rigidity, bradykinesia, postural instability, and cognitive symptoms. Different etiologies leading to the neurodegenerative pathology of the substantia nigra compacta have been suggested. Different inflammatory and immunological factors were proposed as a potential cause of the neurodegenerative process in PD patients. This hypothesis is supported by the increased incidence of PD after different infections such as bacteria, parasites, and viruses.

Design/Methods: A systematic search of 13 databases was performed to ultimately include studies that address the association between infections and PD in humans. The databases included PubMed, Embase, Cochrane, Scopus, Google Scholar, Web of Science (ISI), Popline, New York Academy of Medicine (NYAM), System for Information on Grey Literature in Europe (SIGLE), Global Health Library (GHL), Virtual Health Library (VHL), Clinical Trials (mRCT) and WHO International Trials Registry Platform (ICTRP). Methodological quality was assessed via the National Institute of Health quality assessment tools. Our primary endpoint was assessing the statistical and clinical associations between PD and different infections. The study protocol has been registered in PROSPERO with registration number CRD42017079452.

Results: 60,493 records were identified in our literature search, and 20 articles were finally included in the meta-analysis. Bacterial infections showed an overall significant association with PD (OR= 2.45; 95% CI= 1.52–3.93). None of the parasitic infections nor the overall viral infections showed a significant result; however, individual viral infections including CMV, HBV, measles, rubella, and VZV showed statistical significance (OR= 4.56; 95% CI= 2.44–8.54, OR= .74; 95% CI= .56–.98, OR= .64; 95% CI= 1.37–5.09, OR= 2.69; 95% CI= 1.23–5.88, OR= 1.2; 95% CI= 1.04–1.39, respectively).

Conclusions: Certain bacterial and viral infections are associated with higher rates of PD.

Disclosure: Dr. Elfaituri has nothing to disclose. Dr. Ghozy has nothing to disclose. Dr. Sakr has nothing to disclose. Dr. Elkolaly has nothing to disclose. Dr. Khattab has nothing to disclose. Dr. Mahmoud has nothing to disclose. Dr. Mahmoud has nothing to disclose. Dr. Mehyar has nothing to disclose. Dr. Alhattab has nothing to disclose. Dr. Ahmed Ismail has nothing to disclose. Dr. Abdelmongy has nothing to disclose. Dr. Fahmy has nothing to disclose. Dr. Gharib has nothing to disclose. Dr. Hallab has nothing to disclose. Dr. Morra has nothing to disclose. Dr. Hirayama has nothing to disclose. Dr. Huy has nothing to disclose.

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