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April 16, 2019; 92 (16)

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Listen: Audio summary of highlighted articles

In Focus

  • Spotlight on the April 16 issue
    Robert A. Gross
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Editorials

  • Leveraging human genetics to inform intervention strategies for multiple sclerosis
    An Goris, Bénédicte Dubois
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  • Effectiveness of oral multiple sclerosis therapies in clinical context
    Tomas Kalincik
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  • A nurse-led model increases quality of care in Parkinson disease
    Paolo Calabresi, Pasquale Nigro, Heidi Beck Schwarz
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  • Turning the tide on targeted treatments for neurodevelopmental disorders
    Randi Hagerman, Roberto Tuchman
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Articles

  • Effect of age at puberty on risk of multiple sclerosisA mendelian randomization study
    Adil Harroud, John A. Morris, Vincenzo Forgetta, Ruth Mitchell, George Davey Smith, Stephen J. Sawcer, J. Brent Richards
    • Abstract
    • Full Text
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  • Comparative effectiveness of teriflunomide and dimethyl fumarateA nationwide cohort study
    Mathias Due Buron, Thor Ameri Chalmer, Finn Sellebjerg, Jette Frederiksen, Monika Katarzyna Góra, Zsolt Illes, Matthias Kant, Zsolt Mezei, Thor Petersen, Peter Vestergaard Rasmussen, Homayoun Roshanisefat, Houry Hassanpour-Kalam-Roudy, Tobias Sejbæk, Anna Tsakiri, Arkadiusz Weglewski, Per Soelberg Sorensen, Melinda Magyari
    • Abstract
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  • Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies
    Aron S. Buchman, Lei Yu, Robert S. Wilson, Sue E. Leurgans, Sukriti Nag, Joshua M. Shulman, Lisa L. Barnes, Julie A. Schneider, David A. Bennett
    • Abstract
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  • Randomized trial of care management to improve Parkinson disease care quality
    Karen I. Connor, Eric M. Cheng, Frances Barry, Hilary C. Siebens, Martin L. Lee, David A. Ganz, Brian S. Mittman, Megan K. Connor, Lisa K. Edwards, Michael G. McGowan, Barbara G. Vickrey
    • Abstract
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  • Top-down alteration of functional connectivity within the sensorimotor network in focal dystonia
    Giovanni Battistella, Kristina Simonyan
    • Abstract
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  • X-linked myotubular myopathyA prospective international natural history study
    Mélanie Annoussamy, Charlotte Lilien, Teresa Gidaro, Elena Gargaun, Virginie Chê, Ulrike Schara, Andrea Gangfuß, Adele D'Amico, James J. Dowling, Basil T. Darras, Aurore Daron, Arturo Hernandez, Capucine de Lattre, Jean-Michel Arnal, Michèle Mayer, Jean-Marie Cuisset, Carole Vuillerot, Stéphanie Fontaine, Rémi Bellance, Valérie Biancalana, Ana Buj-Bello, Jean-Yves Hogrel, Hal Landy, Laurent Servais
    • Abstract
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  • Increase of arginine dimethylation correlates with the progression and prognosis of ALS
    Kensuke Ikenaka, Naoki Atsuta, Yasuhiro Maeda, Yuji Hotta, Ryoichi Nakamura, Kaori Kawai, Daichi Yokoi, Akihiro Hirakawa, Akira Taniguchi, Mitsuya Morita, Kouichi Mizoguchi, Hideki Mochizuki, Kazunori Kimura, Masahisa Katsuno, Gen Sobue
    • Abstract
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  • KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD
    Claire M. Erickson, Stephanie A. Schultz, Jennifer M. Oh, Burcu F. Darst, Yue Ma, Derek Norton, Tobey Betthauser, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin, Sanjay Asthana, Bruce P. Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Corinne D. Engelman, Bradley T. Christian, Sterling C. Johnson, Dena B. Dubal, Ozioma C. Okonkwo
    • Abstract
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  • Comment: Longevity gene KLOTHO may play a role in Alzheimer disease
    Argonde C. van Harten
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  • Open Access
    A prospective study of serum metabolites and risk of ischemic stroke
    Daokun Sun, Steffen Tiedt, Bing Yu, Xueqiu Jian, Rebecca F. Gottesman, Thomas H. Mosley, Eric Boerwinkle, Martin Dichgans, Myriam Fornage
    • Abstract
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  • Open Access
    Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine
    Gerrit L.J. Onderwater, Lannie Ligthart, Mariska Bot, Ayse Demirkan, Jingyuan Fu, Carla J.H. van der Kallen, Lisanne S. Vijfhuizen, René Pool, Jun Liu, Floris H.M. Vanmolkot, Marian Beekman, Ke-xin Wen, Najaf Amin, Carisha S. Thesing, Judith A. Pijpers, Dennis A. Kies, Ronald Zielman, Irene de Boer, Marleen M.J. van Greevenbroek, Ilja C.W. Arts, Yuri Milaneschi, Miranda T. Schram, Pieter C. Dagnelie, Lude Franke, M. Arfan Ikram, Michel D. Ferrari, Jelle J. Goeman, P. Eline Slagboom, Cisca Wijmenga, Coen D.A. Stehouwer, Dorret I. Boomsma, Cornelia M. van Duijn, Brenda W. Penninx, Peter A.C. 't Hoen, Gisela M. Terwindt, Arn M.J.M. van den Maagdenberg, on behalf of the BBMRI Metabolomics Consortium
    • Abstract
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  • Open Access
    Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome
    Daniel G. Glaze, Jeffrey L. Neul, Walter E. Kaufmann, Elizabeth Berry-Kravis, Sean Condon, George Stoms, Sean Oosterholt, Oscar Della Pasqua, Larry Glass, Nancy E. Jones, Alan K. Percy
    • Abstract
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    CME Course
  • Characteristics and predictors of 7- and 30-day hospital readmissions to pediatric neurology
    Annie Hong, Yash Shah, Kanwaljit Singh, Shefali Karkare, Sanjeev Kothare
    • Abstract
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    CME Course

What's Happening in Neurology® Genetics

  • What's Happening in Neurology® Genetics
    • Full Text
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Clinical Implications of Neuroscience Research

  • Nucleocytoplasmic transportMechanisms and involvement in neurodegenerative disease
    Eduardo E. Benarroch
    • Full Text
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Clinical/Scientific Notes

  • Tocilizumab treatment in severe recurrent anti-MOG-associated optic neuritis
    Helen Hayward-Koennecke, Markus Reindl, Roland Martin, Sven Schippling
    • Full Text
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Visions

  • Persistent connection
    Andrew Silverman
    • Full Text
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NeuroImages

  • Exceptional involvement of medulla oblongata in Wilson disease
    Aurélia Poujois, Antoine Guillonnet, France Woimant
    • Full Text
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Resident & Fellow Section

  • Right Brain: Silence
    Ricardo Varela
    • Full Text
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  • Teaching NeuroImages: The curious case of the brainstem kink
    Ratika Srivastava, Francois-Dominique Morneau-Jacob
    • Full Text
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  • Teaching NeuroImages: Waardenburg syndrome type 2
    Marcos Rosa Júnior, Larissa Marques Santana, Bernardo Faria Ramos, Henrique Faria Ramos
    • Full Text
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  • Teaching NeuroImages: A disintegrating rock
    Maximiliano A. Hawkes, Alejandro A. Rabinstein
    • Full Text
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Disputes & Debates: Editors' Choice

  • Editors' note: The systolic blood pressure sweet spot after intracerebral hemorrhage: 130 mm Hg?
    Aravind Ganesh, Steven Galetta
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  • Reader response: The systolic blood pressure sweet spot after intracerebral hemorrhage: 130 mm Hg?
    Sunil Munakomi
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  • Author response: The systolic blood pressure sweet spot after intracerebral hemorrhage: 130 mm Hg?
    Gregory Kapinos, Daniel F. Hanley
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  • Editors' note: Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage
    James E. Siegler, Steven Galetta
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  • Reader response: Cerebral ischemia and deterioration with lower blood pressure target in intracerebral hemorrhage
    Simona Lattanzi, Mauro Silvestrini
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