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April 23, 2019; 92 (17) Article

Cognitive phenotypes in temporal lobe epilepsy are associated with distinct patterns of white matter network abnormalities

Anny Reyes, Erik Kaestner, Naeim Bahrami, Akshara Balachandra, Manu Hegde, Brianna M. Paul, Bruce Hermann, Carrie R. McDonald
First published March 27, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007370
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Article Information

vol. 92 no. 17 e1957-e1968
DOI: 
https://doi.org/10.1212/WNL.0000000000007370
PubMed: 
30918094
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received September 28, 2018
  • Accepted in final form December 31, 2018
  • First Published March 27, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Anny Reyes, MS,
    2. Erik Kaestner, PhD,
    3. Naeim Bahrami, PhD,
    4. Akshara Balachandra, BS,
    5. Manu Hegde, MD, PhD,
    6. Brianna M. Paul, PhD,
    7. Bruce Hermann, PhD and
    8. Carrie R. McDonald, PhD
  1. Anny Reyes, MS,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Erik Kaestner, PhD,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Naeim Bahrami, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Akshara Balachandra, BS,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Manu Hegde, MD, PhD,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. 1) Insys - funding for travel to meeting of epilepsy specialists at Insys headquarters

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1) San Francisco VA Medical Center, staff physician (part-time), 2012- present 2) NIH/NINDS, Discovery of Novel Molecular Abnormalities Underlying Non-lesional Focal Epilepsy, 130817A (subcontract), site principal investigator, 8/1/2016-12/1/2018 3) NIH/NINDS, Multimodal imaging of cognitive networks in epilepsy: Implications for surgery, A126506 R01NS065838, site co-investigator, 2015-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1) Epilepsy Study Consortium 2) Finding a Cure for Epilepsy and Seizures

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Brianna M. Paul, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH/NINDS, R01 NS065838, Co-PI/Consortium PI, 07/01/10-09/14/15 NIH/NICHD, RO1 HD079568, Co-PI, 04/01/15-01/31/20

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Simons Foundation, Simons Variation in Individuals Project (F-CAP), Co-PI, 08/01/10-06/31/14

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Bruce Hermann, PhD and
    8. Scientific Advisory Boards:

    1. Treasurer, International Neuropsychological Society (2014- -current). Member of DSMB for Medtronics (Slate Study)

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Epilepsy & Behavior, Associate Editor, 2013-current Journal of the International Neuropsychological Society, Editorial Board, 2015--present. Neuropsychology Review, Editorial Board, 2015-present.

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH (NINDS 3RO1 NS44351 [PI], R01 AG027161 [Co-I], P50AG3314 [Co-I], 1R01NS064034 [Co-I], and RO1AG031790 [Co-I]).

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Citizens United for Epilepsy Research (Co-PI).

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Carrie R. McDonald, PhD
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Epilepsy & Behavior, editorial board member, 2016-present (no compensation)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. GE Healthcare investigator's grant, 2017-present (not related to this study)

    Research Support, Government Entities:

    1. 1. NIH (NS056091), PI, 2006-2011 2. NIH (NS065838), PI, 2010-present

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. American Cancer Society IRG: 2015-2019

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From the San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology (A.R.); Center for Multimodal Imaging and Genetics (A.R., E.K., N.B., A.B., C.R.M.) and Department of Psychiatry (C.R.M.), University of California, San Diego; Department of Neurology (M.H., B.M.P.), University of California, San Francisco; UCSF Comprehensive Epilepsy Center (M.H., B.M.P.), San Francisco; Matthews Neuropsychology Section (B.H.), University of Wisconsin–Madison; and UCSD Comprehensive Epilepsy Center (C.R.M.), San Diego, CA.
  1. Correspondence
    Dr. McDonald camcdonald{at}ucsd.edu
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