Article Figures & Data
Figures
- Figure 1 Consort flow
Fragile cognitive status indicates individuals with cognitive deficits suggestive of early mild cognitive impairment. GI = gastrointestinal; mITT = modified intent-to-treat; SAE = serious adverse event.
- Figure 2 Trial timeline
Full assessment (on site): baseline (BL), 3 months, 12 months, 24 months. Safety follow-up (on site): 1 month, 6 months, 18 months. Safety follow-up (telephone): 9 months, 15 months, 21 months. ** T1-weighted (EN, BL, 3 months, 12 months, 24 months), fluid-attenuated inversion recovery (EN, 24 months), diffusion-weighted imaging (EN, 24 months), arterial spin labeling (BL, 3 months, 12 months, 24 months), resting-state fMRI (BL, 3 months, 12 months, 24 months), gradient echo quantitative T2* task (BL, 3 months, 12 months, 24 months), task fMRI (BL, 3 months, 12 months, 24 months). EN = enrollment; LP = lumbar puncture; RBANS = repeatable battery for assessment of neuropsychological status; UPSIT = University of Pennsylvania Smell Identification Test.
- Figure 3 Treatment effects on Alzheimer Progression Score (APS)
Results for primary and exploratory secondary outcomes are represented. (A) There was no meaningful difference in APS rate of change between treatment groups. (B) Mean change from baseline (± standard error of the mean) in APS did not differ between the 2 treatment groups at any time during the treatment interval. However, APS for both groups increased after 12 and 24 months (*p < 0.05). Data are represented as point estimates (group means) with error bars (standard error of the mean). BL = Baseline; M = months.
- Figure 4 Treatment effects on neurosensory and CSF biomarker measures
Linear mixed effect models did not indicate any difference between naproxen- and placebo-assigned groups in rate of change of (A) cognitive or neurosensory or (B) biological markers of Alzheimer disease. University of Pennsylvania Smell Identification Test (UPSIT) scores decreased over the 2-year trial period for the whole group (*p < 0.05). Data are represented as point estimates (group means) with error bars (standard error of the mean). BL = baseline; p-tau = phosphorylated tau; RBANS = Repeatable Battery for the Assessment of Neuropsychological Status; t-tau = total tau.
Tables
Letters: Rapid online correspondence
- Author response: INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease
- Reader response: INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease
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