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May 07, 2019; 92 (19) Article

Lipid levels and the risk of hemorrhagic stroke among women

Pamela M. Rist, Julie E. Buring, Paul M Ridker, Carlos S. Kase, View ORCID ProfileTobias Kurth, Kathryn M. Rexrode
First published April 10, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007454
Pamela M. Rist
From the Division of Preventive Medicine, Department of Medicine (P.M. Rist, J.E.B., P.M Ridker), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (C.S.K.), Emory University, Atlanta, GA; Institute of Public Health (T.K.), Charité–Universitätsmedizin, Berlin, Germany; and Division of Women's Health, Department of Medicine (K.M.R.), Brigham and Women's Hospital, Boston, MA.
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Julie E. Buring
From the Division of Preventive Medicine, Department of Medicine (P.M. Rist, J.E.B., P.M Ridker), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (C.S.K.), Emory University, Atlanta, GA; Institute of Public Health (T.K.), Charité–Universitätsmedizin, Berlin, Germany; and Division of Women's Health, Department of Medicine (K.M.R.), Brigham and Women's Hospital, Boston, MA.
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Paul M Ridker
From the Division of Preventive Medicine, Department of Medicine (P.M. Rist, J.E.B., P.M Ridker), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (C.S.K.), Emory University, Atlanta, GA; Institute of Public Health (T.K.), Charité–Universitätsmedizin, Berlin, Germany; and Division of Women's Health, Department of Medicine (K.M.R.), Brigham and Women's Hospital, Boston, MA.
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Carlos S. Kase
From the Division of Preventive Medicine, Department of Medicine (P.M. Rist, J.E.B., P.M Ridker), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (C.S.K.), Emory University, Atlanta, GA; Institute of Public Health (T.K.), Charité–Universitätsmedizin, Berlin, Germany; and Division of Women's Health, Department of Medicine (K.M.R.), Brigham and Women's Hospital, Boston, MA.
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Tobias Kurth
From the Division of Preventive Medicine, Department of Medicine (P.M. Rist, J.E.B., P.M Ridker), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (C.S.K.), Emory University, Atlanta, GA; Institute of Public Health (T.K.), Charité–Universitätsmedizin, Berlin, Germany; and Division of Women's Health, Department of Medicine (K.M.R.), Brigham and Women's Hospital, Boston, MA.
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  • ORCID record for Tobias Kurth
Kathryn M. Rexrode
From the Division of Preventive Medicine, Department of Medicine (P.M. Rist, J.E.B., P.M Ridker), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (C.S.K.), Emory University, Atlanta, GA; Institute of Public Health (T.K.), Charité–Universitätsmedizin, Berlin, Germany; and Division of Women's Health, Department of Medicine (K.M.R.), Brigham and Women's Hospital, Boston, MA.
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Lipid levels and the risk of hemorrhagic stroke among women
Pamela M. Rist, Julie E. Buring, Paul M Ridker, Carlos S. Kase, Tobias Kurth, Kathryn M. Rexrode
Neurology May 2019, 92 (19) e2286-e2294; DOI: 10.1212/WNL.0000000000007454

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Article Information

vol. 92 no. 19 e2286-e2294
DOI: 
https://doi.org/10.1212/WNL.0000000000007454
PubMed: 
30971484

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received July 25, 2018
  • Accepted in final form January 14, 2019
  • First Published April 10, 2019.

Article Versions

  • Previous version (April 10, 2019 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Pamela M. Rist, ScD,
    2. Julie E. Buring, ScD,
    3. Paul M Ridker, MD, MPH,
    4. Carlos S. Kase, MD,
    5. Tobias Kurth, MD, ScD* and
    6. Kathryn M. Rexrode, MD, MPH*
  1. Pamela M. Rist, ScD,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Charit? ? Universit?tsmedizin Berlin, funding for travel and speaker honoraria

    Editorial Boards:
    1. Stroke, statistical editor, 2016-present

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NHLBI, K01HL128791, Principle investigator, 2016-present NHLBI, R01HL088521, Project director, 2015-2016

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NCMIC Foundation

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Julie E. Buring, ScD,
  4. Scientific Advisory Boards:
    1. Husband - Scientific Advisory Board of Pharmavite

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. honorarium from Bayer for presenting Women's Health Study trial results at a symposium at national meeting, 2005

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Research support for pills and/or packaging was provided by Bayer HeathCare and the Natural Source Vitamin E Association for the Women's Health Study.

    Research Support, Government Entities:
    1. NIH grants supporting the Women's Health Study

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Paul M Ridker, MD, MPH,
  6. Scientific Advisory Boards:
    1. 1). Corvidia, BioCivi 2). NHLBI

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. 1). Novartis, Amgen, Jannsen, Merck - consultant

    Editorial Boards:
    1. 1. Circulation Research, AHA 5 years

    Patents:
    1. 1. Patents related to the use of inflammatory biomarkers in cardiovascular disease held by the Brigham and Women's Hospital and licensed to Seimens.

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. 1). Novartis, Amgen, Jannsen, Merck - consultant

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Novartis, Kowa, Pfizer - unrelated research grants

    Research Support, Government Entities:
    1. NHLBI, NCI - unrelated research grants

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License fee payments, Technology or Inventions:
    1. 1. Patents related to the use of inflammatory biomarkers in cardiovascular disease held by the Brigham and Women's Hospital and licensed to Seimens.

    Royalty Payments, Technology or Inventions:
    1. 1. Patents related to the use of inflammatory biomarkers in cardiovascular disease held by the Brigham and Women's Hospital and licensed to Seimens.

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Carlos S. Kase, MD,
  8. Scientific Advisory Boards:
    1. Boehringer-Ingelheim

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Boehringer-Ingelheim

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. Boehringer-Ingelheim

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Tobias Kurth, MD, ScD* and
  10. Scientific Advisory Boards:
    1. (1) Commercial (Lilly, Newsenselab), for providing methodological advice.

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) Commercial (Novartis, Daiichi Sankyo), for providing a lecture on neuroepidemiology and research methods

    Editorial Boards:
    1. (1) BMJ, for duties as consulting clinical epidemiology editor.

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. (1) The Federal Joint Committee Germany, PI of evaluations (ANNOTeM, TNAMSE, SMARTGEM).

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Kathryn M. Rexrode, MD, MPH*
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Invited speaker for the International Magnesium conference in Rome 2017 ($500 to cover travel)

    Editorial Boards:
    1. Neuology and JAMA Internal Medicine editorial advisory boards

    Patents:
    1. NONE

    Publishing Royalties:
    1. Editor, Women and Health 2012 (2016 <600$)

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. Quincy Bioscience- review of safety reports on over the counter supplements. Prenatal multivitamin review

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NHLBI R01- "risk factors for ischemic stroke" ongoing

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. Scientific Board for Tegterra/ Inside Tracker. Stock options only with 0$ worth (no stock currently available- not publicly traded- I think unlikely to be ever stock)

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Division of Preventive Medicine, Department of Medicine (P.M. Rist, J.E.B., P.M Ridker), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Neurology (C.S.K.), Emory University, Atlanta, GA; Institute of Public Health (T.K.), Charité–Universitätsmedizin, Berlin, Germany; and Division of Women's Health, Department of Medicine (K.M.R.), Brigham and Women's Hospital, Boston, MA.
  1. Correspondence
    Dr. Rist prist{at}mail.harvard.edu
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Cited By...

  • 52 Citations
  • Google Scholar

Letters: Rapid online correspondence

  • Author response: Lipid levels and the risk of hemorrhagic stroke among women
    • Pamela M. Rist, Assistant Professor, Brigham and Women's Hospital and Harvard Medical School
    • Tobias Kurth, Professor, Charite–Universitatsmedizin
    • Kathryn M. Rexrode, Associate Professor, Brigham and Women's Hospital and Harvard Medical School
    Submitted December 11, 2019
  • Author response: Lipid levels and the risk of hemorrhagic stroke among women
    • Pamela M. Rist, Assistant Professor, Brigham and Women's Hospital and Harvard Medical School
    • Tobias Kurth, Professor, Charite–Universitatsmedizin
    • Kathryn M. Rexrode, Associate Professor, Brigham and Women's Hospital and Harvard Medical School
    Submitted December 11, 2019
  • Reader response: Lipid levels and the risk of hemorrhagic stroke among women
    • Laurens F. Reeskamp, MD, PhD Candidate, Department of Vascular Medicine, Amsterdam UMC
    • Renate M. Hoogeveen, MD, PhD Candidate, Department of Vascular Medicine, Amsterdam UMC
    Submitted July 01, 2019
  • Reader response: Lipid levels and the risk of hemorrhagic stroke among women
    • Akif Gani, Consultant Stroke Physician, Newcastle upon Tyne Hospitals
    Submitted April 17, 2019
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