Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

January 29, 2019; 92 (5) Editorial

Heterogeneity, urgency, generalizability, and enrollment

The HUGE balance in ALS trials

Chafic Karam, James D. Berry
First published January 9, 2019, DOI: https://doi.org/10.1212/WNL.0000000000006837
Chafic Karam
From the Department of Neurology (C.K.), Oregon Health & Science University, Portland; and Department of Neurology (J.D.B.), Massachusetts General Hospital, Boston.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James D. Berry
From the Department of Neurology (C.K.), Oregon Health & Science University, Portland; and Department of Neurology (J.D.B.), Massachusetts General Hospital, Boston.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Heterogeneity, urgency, generalizability, and enrollment
The HUGE balance in ALS trials
Chafic Karam, James D. Berry
Neurology Jan 2019, 92 (5) 215-216; DOI: 10.1212/WNL.0000000000006837

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
85

Share

  • Article
  • Info & Disclosures
Loading

Article Information

vol. 92 no. 5 215-216
DOI: 
https://doi.org/10.1212/WNL.0000000000006837
PubMed: 
30626648

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • First Published January 9, 2019.

Article Versions

  • Previous version (January 9, 2019 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Chafic Karam, MD and
    2. James D. Berry, MD, MPH
  1. Chafic Karam, MD and
  2. Scientific Advisory Boards:
    1. I serve on DMSB for a Phase 2/3 Trial of Arimoclomol in Inclusion Body Myositis (IBM)

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. I have received speaker honoraria from Akcea, Alnylam, Alexion and CSL behring.

    Editorial Boards:
    1. I served on the editorial board of the Neurology Resident and Fellow section. I served as Deputy Editor, Neurology Write Click, Dispute and Debate.

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. I have received consulting honoraria from Akcea, Alnylam, Alexion, Biogen, Cytokinetics, Genzyme and CSL Behring.

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. James D. Berry, MD, MPH
  4. Scientific Advisory Boards:
    1. (1) MT Pharma (commercial entity) - attended one-day scientific advisory meeting (2) Denali Therapeutics (commercial entity) - attended one-day scientific advisory meeting (3) Orion Corporation (commercial entity) - attended one- day scientific advisory meeting (4) Anelixis Therapeutics (commercial entity) - advisor to company (5) Mayo Clinic (non-profit entity) - DSMB member for ALS stem cell trial

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. (1) ALS Association (non-profit entity) - reimbursed for travel to ALS patient symposium (2) MDA (non-profit entity) - reimbursed for travel to scientific conference (3) ALS One (non-profit entity) - reimbursed for travel to ALS advocacy meeting (4) ALS Finding a Cure (non-profit entity) - reimbursed for travel to ALS research meetings

    Editorial Boards:
    1. Wife (Ann Shinn) - Neuropsychopharmacology - Editorial Board Member

    Patents:
    1. MicroRNAs in neurodegenerative disorders (WO2013055865)

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. (1) Voyager Therapeutics - Commercial Entity - Fellowship Funding (2) Neuraltus Pharmaceuticals - Commercial entity - Site Investigator for Trial (3) Cytokinetics - Commercial entity - Site Investigator for Trial (4) Brainstorm Cell Therapeutics - Commercial entity - Site Investigator for Trial (5) Amylyx Pharmaceuticals - Commercial entity - Site Investigator for Trial (6)

    Research Support, Government Entities:
    1. (1) NIH/NINDS (PI: Steven M. Greenberg) Co-Investigator, 2011-2018 (2) NIH R01DC013547 (PI: Jordan Green) Co-PI, 2014-2019 (3) NIH/NINDS R21 NS101673 (PI: Butovsky) Co-PI, 2017-2019 (4) NIH/NINDS R21 NS104609 (PI: Butovsky) Co-PI, 2018-2020 (5) NIH-R01 DC017291 (PIs: Green and Yunusova) Co-I, 2018- 2023

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. (1) Muscular Dystrophy Association (2) ALS Finding a Cure (3) ALS Association (4) ALS One

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. MicroRNAs in neurodegenerative disorders (WO2013055865) - Licensing royalty

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology (C.K.), Oregon Health & Science University, Portland; and Department of Neurology (J.D.B.), Massachusetts General Hospital, Boston.
  1. Correspondence
    Dr. Karam chafickaram{at}gmail.com
View Full Text

Article usage

Article usage: January 2019 to March 2021

AbstractFullPdfSource
Jan 20193992931Highwire
Feb 20191301114Highwire
Mar 20195269Highwire
Apr 20192745Highwire
May 20193210Highwire
Jun 20193112Highwire
Jul 20193121Highwire
Aug 20191910Highwire
Sep 20193513Highwire
Oct 20192011Highwire
Nov 20193314Highwire
Dec 20191211Highwire
Jan 20201423Highwire
Feb 20202233Highwire
Mar 20203100Highwire
Apr 20201633Highwire
May 20201500Highwire
Jun 20201100Highwire
Jul 20201521Highwire
Aug 20201212Highwire
Sep 20201010Highwire
Oct 20202410Highwire
Nov 20201710Highwire
Dec 20202511Highwire
Jan 20211200Highwire
Feb 20212200Highwire
Mar 20211621Highwire

Cited By...

  • 2 Citations
  • Google Scholar

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Study funding
    • Disclosure
    • Footnotes
    • References
  • Info & Disclosures
Advertisement

Related Articles

  • Refining eligibility criteria for amyotrophic lateral sclerosis clinical trials

Topics Discussed

  • All Clinical trials
  • Amyotrophic lateral sclerosis
  • Clinical trials Methodology/study design
  • Prognosis

Alert Me

  • Alert me when eletters are published
Neurology: 96 (15)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise