Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Specialty Sites
    • COVID-19
    • Practice Current
    • Practice Buzz
    • Without Borders
    • Equity, Diversity and Inclusion
    • Innovations in Care Delivery
  • Collections
    • Topics A-Z
    • Residents & Fellows
    • Infographics
    • Patient Pages
    • Null Hypothesis
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit a Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Residents & Fellows

Share

January 29, 2019; 92 (5) ArticleOpen Access

Refining eligibility criteria for amyotrophic lateral sclerosis clinical trials

Ruben P.A. van Eijk, Henk-Jan Westeneng, Stavros Nikolakopoulos, Iris E. Verhagen, Michael A. van Es, Marinus J.C. Eijkemans, Leonard H. van den Berg
First published January 9, 2019, DOI: https://doi.org/10.1212/WNL.0000000000006855
Ruben P.A. van Eijk
From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henk-Jan Westeneng
From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stavros Nikolakopoulos
From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Iris E. Verhagen
From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael A. van Es
From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marinus J.C. Eijkemans
From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonard H. van den Berg
From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Short Form
Citation
Refining eligibility criteria for amyotrophic lateral sclerosis clinical trials
Ruben P.A. van Eijk, Henk-Jan Westeneng, Stavros Nikolakopoulos, Iris E. Verhagen, Michael A. van Es, Marinus J.C. Eijkemans, Leonard H. van den Berg
Neurology Jan 2019, 92 (5) e451-e460; DOI: 10.1212/WNL.0000000000006855

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
1070

Share

  • Article
  • Figures & Data
  • Info & Disclosures
Loading

Article Information

vol. 92 no. 5 e451-e460
DOI: 
https://doi.org/10.1212/WNL.0000000000006855
PubMed: 
30626653

Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received June 22, 2018
  • Accepted in final form September 19, 2018
  • First Published January 9, 2019.

Article Versions

  • Previous version (January 9, 2019 - 12:45).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND), which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Author Disclosures

    1. Ruben P.A. van Eijk, MD, MSc,
    2. Henk-Jan Westeneng, MD,
    3. Stavros Nikolakopoulos, PhD,
    4. Iris E. Verhagen, MD,
    5. Michael A. van Es, MD, PhD,
    6. Marinus J.C. Eijkemans, PhD and
    7. Leonard H. van den Berg, MD, PhD
  1. Ruben P.A. van Eijk, MD, MSc,
  2. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  3. Henk-Jan Westeneng, MD,
  4. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  5. Stavros Nikolakopoulos, PhD,
  6. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  7. Iris E. Verhagen, MD,
  8. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  9. Michael A. van Es, MD, PhD,
  10. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  11. Marinus J.C. Eijkemans, PhD and
  12. Scientific Advisory Boards:
    1. NONE

    Gifts:
    1. NONE

    Funding for Travel or Speaker Honoraria:
    1. NONE

    Editorial Boards:
    1. NONE

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other Activities:
    1. NONE

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. NONE

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  13. Leonard H. van den Berg, MD, PhD
  14. Scientific Advisory Boards:
    1. Scientific Advisory Boards of Biogen, Cytokinetics, Wave Life Sciences, Freeway, Sarepta

    Gifts:
    1. NONE

    Funding for travel or speaker honoraria:
    1. Octapharma, Shire

    Editorial Boards:
    1. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Journal of Neurology, Neurosurgery and Psychiatry Neuromuscular Disorders

    Patents:
    1. NONE

    Publishing Royalties:
    1. NONE

    Employment, Commercial Entity:
    1. NONE

    Consultancies:
    1. NONE

    Speakers' Bureaus:
    1. NONE

    Other activities:
    1. received an educational grant from Shire

    Clinical Procedures or Imaging Studies:
    1. NONE

    Research Support, Commercial Entities:
    1. NONE

    Research Support, Government Entities:
    1. NONE

    Research Support, Academic Entities:
    1. NONE

    Research Support, Foundations and Societies:
    1. The Netherlands ALS Foundation; Netherlands Organisation for Health Research and Development (Vici scheme)

    Stock/Stock Options/Board of Directors Compensation:
    1. NONE

    License Fee Payments, Technology or Inventions:
    1. NONE

    Royalty Payments, Technology or Inventions:
    1. NONE

    Stock/Stock Options, Research Sponsor:
    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:
    1. NONE

    Legal Proceedings:
    1. NONE

  1. From the Department of Neurology (R.P.A.v.E., H.-J.W., I.E.V., M.A.v.E., L.H.v.d.B.), Brain Center Rudolf Magnus, and Biostatistics & Research Support (R.P.A.v.E., S.N., M.J.C.E.), Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands.
  1. Correspondence
    Dr. van den Berg lberg{at}umcutrecht.nl
View Full Text

Article usage

Article usage: January 2019 to January 2021

AbstractFullPdfSource
Jan 2019684110219Highwire
Feb 20195667197Highwire
Mar 20191770663Highwire
Apr 20192166567Highwire
May 20191327840Highwire
Jun 20191116038Highwire
Jul 2019510822Highwire
Aug 201989527Highwire
Sep 2019540423Highwire
Oct 2019116824Highwire
Nov 2019156827Highwire
Dec 2019912521Highwire
Jan 2020622621Highwire
Feb 20201434620Highwire
Mar 20201247326Highwire
Apr 20201933791Highwire
May 20201730720Highwire
Jun 2020410718Highwire
Jul 202033513Highwire
Aug 202074920Highwire
Sep 202056728Highwire
Oct 202047736Highwire
Nov 202094932Highwire
Dec 2020517341Highwire
Jan 2021105936Highwire

Cited By...

  • 16 Citations
  • Google Scholar

Disputes & Debates: Rapid online correspondence

No comments have been published for this article.
Comment

NOTE: All authors' disclosures must be entered and current in our database before comments can be posted. Enter and update disclosures at http://submit.neurology.org. Exception: replies to comments concerning an article you originally authored do not require updated disclosures.

  • Stay timely. Submit only on articles published within the last 8 weeks.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • 200 words maximum.
  • 5 references maximum. Reference 1 must be the article on which you are commenting.
  • 5 authors maximum. Exception: replies can include all original authors of the article.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Disputes & Debates Submission Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Author contributions
    • Study funding
    • Disclosure
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures
Advertisement

Related Articles

  • Heterogeneity, urgency, generalizability, and enrollmentThe HUGE balance in ALS trials

Topics Discussed

  • Parkinson's disease/Parkinsonism
  • Risk factors in epidemiology

Alert Me

  • Alert me when eletters are published
Neurology: 96 (9)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2021 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise