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February 12, 2019; 92 (7) Editorial

Serum neurofilament light and prediction of multiple sclerosis in clinically isolated syndrome

Henrik Zetterberg, Anders Svenningsson
First published January 11, 2019, DOI: https://doi.org/10.1212/WNL.0000000000006906
Henrik Zetterberg
From the Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; and Department of Clinical Sciences (A.S.), Danderyd Hospital, Karolinska Institutet, Danderyd Hospital AB, Stockholm, Sweden.
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Anders Svenningsson
From the Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (H.Z.), London; and Department of Clinical Sciences (A.S.), Danderyd Hospital, Karolinska Institutet, Danderyd Hospital AB, Stockholm, Sweden.
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Serum neurofilament light and prediction of multiple sclerosis in clinically isolated syndrome
Henrik Zetterberg, Anders Svenningsson
Neurology Feb 2019, 92 (7) 313-314; DOI: 10.1212/WNL.0000000000006906

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Clinically isolated syndrome (CIS) refers to a first episode of multiple sclerosis (MS)–like neurologic symptoms that lasts at least 24 hours followed by complete or partial recovery. Individuals who experience CIS may or may not go on to develop MS. The most notable risk factors for MS during follow-up are MRI lesions and CSF oligoclonal bands.1 More recently, CSF neurofilament light (NfL) concentration, a general marker of axonal injury, has been proposed as predictive of future MS in CIS.2

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  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

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  • © 2019 American Academy of Neurology
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