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Clinically isolated syndrome (CIS) refers to a first episode of multiple sclerosis (MS)–like neurologic symptoms that lasts at least 24 hours followed by complete or partial recovery. Individuals who experience CIS may or may not go on to develop MS. The most notable risk factors for MS during follow-up are MRI lesions and CSF oligoclonal bands.1 More recently, CSF neurofilament light (NfL) concentration, a general marker of axonal injury, has been proposed as predictive of future MS in CIS.2
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