Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit New Manuscript
    • Submit Revised Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

February 19, 2019; 92 (8) Article

Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults

H. Lina Schaare, Shahrzad Kharabian Masouleh, Frauke Beyer, Deniz Kumral, Marie Uhlig, Janis D. Reinelt, Andrea M.F. Reiter, Leonie Lampe, Anahit Babayan, Miray Erbey, Josefin Roebbig, Matthias L. Schroeter, Hadas Okon-Singer, Karsten Müller, Natacha Mendes, Daniel S. Margulies, A. Veronica Witte, Michael Gaebler, Arno Villringer
First published January 23, 2019, DOI: https://doi.org/10.1212/WNL.0000000000006947
H. Lina Schaare
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shahrzad Kharabian Masouleh
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frauke Beyer
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Deniz Kumral
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marie Uhlig
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Janis D. Reinelt
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrea M.F. Reiter
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leonie Lampe
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anahit Babayan
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miray Erbey
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Josefin Roebbig
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias L. Schroeter
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hadas Okon-Singer
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Karsten Müller
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Natacha Mendes
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel S. Margulies
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Veronica Witte
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Gaebler
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arno Villringer
From the Department of Neurology (H.L.S., S.K.M., F.B., D.K., M.U., J.D.R., A.M.F.R., L.L., A.B., M.E., J.R., M.L.S., A.V.W., M.G., A.V.), Max Planck Research Group for Neuroanatomy & Connectivity (N.M., D.S.M.), and Nuclear Magnetic Resonance Group (K.M.), Max Planck Institute for Human Cognitive and Brain Sciences; International Max Planck Research School NeuroCom (H.L.S., M.U.), Leipzig; MindBrainBody Institute at Berlin School of Mind and Brain (D.K., A.B., M.E., M.G., A.V.), Charité & Humboldt Universität zu Berlin; Lifespan Developmental Neuroscience (A.M.F.R.), Technische Universität Dresden; Leipzig Research Centre for Civilization Diseases (LIFE) (M.L.S., M.G., A.V.), Clinic for Cognitive Neurology (M.L.S., A.V.), and Collaborative Research Centre 1052 ‘Obesity Mechanisms,’ Subproject A1, Faculty of Medicine (F.B., A.V.W., A.V.), University of Leipzig, Germany; Department of Psychology (H.O.-S.), University of Haifa, Israel; and Center for Stroke Research Berlin (A.V.), Charité–Universitätsmedizin Berlin, Germany.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Short Form
Citation
Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults
H. Lina Schaare, Shahrzad Kharabian Masouleh, Frauke Beyer, Deniz Kumral, Marie Uhlig, Janis D. Reinelt, Andrea M.F. Reiter, Leonie Lampe, Anahit Babayan, Miray Erbey, Josefin Roebbig, Matthias L. Schroeter, Hadas Okon-Singer, Karsten Müller, Natacha Mendes, Daniel S. Margulies, A. Veronica Witte, Michael Gaebler, Arno Villringer
Neurology Feb 2019, 92 (8) e758-e773; DOI: 10.1212/WNL.0000000000006947

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
1068

Share

This article has a correction. Please see:

  • Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults - March 05, 2019
  • Article
  • Figures & Data
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Abstract

Objective To test whether elevated blood pressure (BP) relates to gray matter (GM) volume (GMV) changes in young adults who had not previously been diagnosed with hypertension (systolic BP [SBP]/diastolic BP [DBP] ≥140/90 mm Hg).

Methods We associated BP with GMV from structural 3T T1-weighted MRI of 423 healthy adults between 19 and 40 years of age (mean age 27.7 ± 5.3 years, 177 women, SBP/DBP 123.2/73.4 ± 12.2/8.5 mm Hg). Data originated from 4 previously unpublished cross-sectional studies conducted in Leipzig, Germany. We performed voxel-based morphometry on each study separately and combined results in image-based meta-analyses (IBMA) to assess cumulative effects across studies. Resting BP was assigned to 1 of 4 categories: (1) SBP <120 and DBP <80 mm Hg, (2) SBP 120–129 or DBP 80–84 mm Hg, (3) SBP 130–139 or DBP 85–89 mm Hg, (4) SBP ≥140 or DBP ≥90 mm Hg.

Results IBMA yielded the following results: (1) lower regional GMV was correlated with higher peripheral BP; (2) lower GMV was found with higher BP when comparing individuals in subhypertensive categories 3 and 2, respectively, to those in category 1; (3) lower BP-related GMV was found in regions including hippocampus, amygdala, thalamus, frontal, and parietal structures (e.g., precuneus).

Conclusion BP ≥120/80 mm Hg was associated with lower GMV in regions that have previously been related to GM decline in older individuals with manifest hypertension. Our study shows that BP-associated GM alterations emerge continuously across the range of BP and earlier in adulthood than previously assumed. This suggests that treating hypertension or maintaining lower BP in early adulthood might be essential for preventing the pathophysiologic cascade of asymptomatic cerebrovascular disease to symptomatic end-organ damage, such as stroke or dementia.

Glossary

AD=
Alzheimer disease;
ANOVA=
analysis of variance;
BMI=
body mass index;
BP=
blood pressure;
CSFV=
cerebrospinal fluid volume;
CVD=
cerebrovascular disease;
DBP=
diastolic blood pressure;
FA=
flip angle;
FLAIR=
fluid-attenuated inversion recovery;
FOV=
field of view;
FWE=
family-wise error;
GM=
gray matter;
GMV=
gray matter volume;
HTN=
hypertension;
IBMA=
image-based meta-analyses;
LIFE Study=
Leipzig Research Centre for Civilization Diseases Study;
ROI=
region of interest;
SBP=
systolic blood pressure;
SDM=
seed-based d mapping;
TE=
echo time;
TI=
inversion time;
TIV=
total intracranial volume;
TR=
repetition time;
VBM=
voxel-based morphometry;
WM=
white matter;
WMH=
white matter hyperintensities;
WMV=
white matter volume

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Received January 9, 2018.
  • Accepted in final form October 15, 2018.
  • © 2019 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

No comments have been published for this article.
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Abstract
    • Glossary
    • Methods
    • Results
    • Discussion
    • Author contributions
    • Study funding
    • Disclosure
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Info & Disclosures
Advertisement

Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke: A Post Hoc Analysis of the EXTEND-IA TNK Trials

Dr. Nicole Sur and Dr. Mausaminben Hathidara

► Watch

Related Articles

  • Association of peripheral blood pressure with gray matter volume in 19- to 40-year-old adults

Topics Discussed

  • All Cerebrovascular disease/Stroke
  • MRI
  • Vascular dementia
  • Risk factors in epidemiology
  • Stroke prevention

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Article
    Adiposity is related to cerebrovascular and brain volumetry outcomes in the RUN DMC study
    Ilse A.C. Arnoldussen, Deborah R. Gustafson, Esther M.C. Leijsen et al.
    Neurology, July 30, 2019
  • Article
    N-terminal pro–brain natriuretic peptide and abnormal brain aging
    The AGES–Reykjavik Study
    Behnam Sabayan, Mark A. van Buchem, Anton J.M. de Craen et al.
    Neurology, July 31, 2015
  • Articles
    Circulating IL-6 and CRP are associated with MRI findings in the elderly
    The 3C-Dijon Study
    C.L. Satizabal, Y.C. Zhu, B. Mazoyer et al.
    Neurology, February 22, 2012
  • Articles
    Association between blood pressure, white matter lesions, and atrophy of the medial temporal lobe
    T. den Heijer, L. J. Launer, N. D. Prins et al.
    Neurology, January 24, 2005
Neurology: 100 (22)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise