Skip to main content
Advertisement
  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center

Advanced Search

Main menu

  • Neurology.org
  • Journals
    • Neurology
    • Clinical Practice
    • Education
    • Genetics
    • Neuroimmunology & Neuroinflammation
  • Online Sections
    • Neurology Video Journal Club
    • Diversity, Equity, & Inclusion (DEI)
    • Neurology: Clinical Practice Accelerator
    • Practice Buzz
    • Practice Current
    • Residents & Fellows
    • Without Borders
  • Collections
    • COVID-19
    • Disputes & Debates
    • Health Disparities
    • Infographics
    • Neurology Future Forecasting Series
    • Null Hypothesis
    • Patient Pages
    • Topics A-Z
    • Translations
    • UDDA Revision Series
  • Podcast
  • CME
  • About
    • About the Journals
    • Contact Us
    • Editorial Board
  • Authors
    • Submit Manuscript
    • Author Center
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

User menu

  • Subscribe
  • My Alerts
  • Log in

Search

  • Advanced search
Neurology
Home
The most widely read and highly cited peer-reviewed neurology journal
  • Subscribe
  • My Alerts
  • Log in
Site Logo
  • Home
  • Latest Articles
  • Current Issue
  • Past Issues
  • Neurology Video Journal Club
  • Residents & Fellows

Share

July 02, 2019; 93 (1) Editorial

Remote ischemic preconditioning effects on brain vasculature

Paul Nyquist, Marios K. Georgakis
First published May 29, 2019, DOI: https://doi.org/10.1212/WNL.0000000000007724
Paul Nyquist
From the Department of Neurology (P.N.), Anesthesia/Critical Care Medicine, and Department of Neurosurgery, General Internal Medicine (P.N.), Johns Hopkin School of Medicine, Baltimore, MD; and Institute for Stroke and Dementia Research (M.K.G.), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany.
MD, MPH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marios K. Georgakis
From the Department of Neurology (P.N.), Anesthesia/Critical Care Medicine, and Department of Neurosurgery, General Internal Medicine (P.N.), Johns Hopkin School of Medicine, Baltimore, MD; and Institute for Stroke and Dementia Research (M.K.G.), University Hospital, Ludwig-Maximilians-Universität LMU, Munich, Germany.
MD, MSc
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Full PDF
Citation
Remote ischemic preconditioning effects on brain vasculature
Paul Nyquist, Marios K. Georgakis
Neurology Jul 2019, 93 (1) 15-16; DOI: 10.1212/WNL.0000000000007724

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Permissions

Make Comment

See Comments

Downloads
163

Share

  • Article
  • Info & Disclosures
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Remote ischemic preconditioning (RIPC), a brief transient episode of ischemia/reperfusion in distant tissues or organs, renders remote tissues and organs resistant to a subsequent prolonged ischemic insult.1 The RIPC stimulus may include occlusion of blood vessels in animal models, reduction of respired atmospheric oxygen intermittently before ischemia, or occlusion of the arteries of the arm by tourniquet.2 First described in a dog model of cardiac reperfusion in the 1980s, exposure to preclinical ischemic preconditioning involving the temporary occlusion of the coronary arteries restricted the myocardial injury caused by a subsequent sustained occlusion.3 Clinical outcomes in a number of ischemic conditions in humans have shown consistent improvement with RIPC, including decreased infarct size after myocardial infarction,4,5 slower progression of imaging lesions and cognitive decline in patients with cerebral small vessel disease,6 accelerated recovery from hypoxic ischemic brain injury after cardiac arrest,7 and reduced subsequent infarct volumes in patients with severe carotid stenosis undergoing carotid artery stenting.8 RIPC protects cells and tissue from future ischemia via a complex interplay of inflammatory, apoptotic, and neuroregenerative pathways that operate in parallel and in a complex manner.2,9 In the brain, RIPC primes nitric oxide formation, storage, and signaling and triggers synthesis of proapoptotic and antiapoptotic proteins such as B-cell lymphoma 2.2 It also stimulates neurogenesis and angiogenesis by upregulating brain-derived neurotropic factor and vascular endothelial growth factor production.2

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the editorial.

  • See page 18

  • © 2019 American Academy of Neurology
View Full Text

AAN Members

We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.

Google Safari Microsoft Edge Firefox

Click here to login

AAN Non-Member Subscribers

Click here to login

Purchase access

For assistance, please contact:
AAN Members (800) 879-1960 or (612) 928-6000 (International)
Non-AAN Member subscribers (800) 638-3030 or (301) 223-2300 option 3, select 1 (international)

Sign Up
Information on how to subscribe to Neurology and Neurology: Clinical Practice can be found here 

Purchase
Individual access to articles is available through the Add to Cart option on the article page.  Access for 1 day (from the computer you are currently using) is US$ 39.00.  Pay-per-view content is for the use of the payee only, and content may not be further distributed by print or electronic means.  The payee may view, download, and/or print the article for his/her personal, scholarly, research, and educational use.  Distributing copies (electronic or otherwise) of the article is not allowed.

Letters: Rapid online correspondence

  • Author response: Remote ischemic preconditioning effects on brain vasculature
    • Paul Nyquist, Attending Physician, Professor of Medicins JOhns hopkins University
    Submitted July 09, 2019
  • Reader response: Remote ischemic preconditioning effects on brain vasculature
    • Sunil Munakomi, Associate Professor, Neurosurgery, Kathmandu University
    Submitted June 11, 2019
Comment

REQUIREMENTS

You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.

Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.

If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.

Submission specifications:

  • Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
  • Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
  • Submit only on articles published within 6 months of issue date.
  • Do not be redundant. Read any comments already posted on the article prior to submission.
  • Submitted comments are subject to editing and editor review prior to posting.

More guidelines and information on Disputes & Debates

Compose Comment

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
NOTE: The first author must also be the corresponding author of the comment.
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Publishing Agreement
NOTE: All authors, besides the first/corresponding author, must complete a separate Publishing Agreement Form and provide via email to the editorial office before comments can be posted.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

You May Also be Interested in

Back to top
  • Article
    • Study funding
    • Disclosure
    • Footnotes
    • References
  • Info & Disclosures
Advertisement

Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias

Dr. Sevil Yaşar and Dr. Behnam Sabayan

► Watch

Related Articles

  • Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning

Topics Discussed

  • All Clinical Neurology
  • All Cerebrovascular disease/Stroke

Alert Me

  • Alert me when eletters are published

Recommended articles

  • Article
    Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning
    Zhen-Ni Guo, Wei-Tong Guo, Jia Liu et al.
    Neurology, May 29, 2019
  • Article
    Increased CSF biomarkers of angiogenesis in Parkinson disease
    Shorena Janelidze, Daniel Lindqvist, Veronica Francardo et al.
    Neurology, October 28, 2015
  • Clinical Implications of Neuroscience Research
    Hypoxia-induced mediators and neurologic disease
    Eduardo E. Benarroch et al.
    Neurology, August 17, 2009
  • Article
    Inflammatory biomarkers, cerebral microbleeds, and small vessel disease
    Framingham Heart Study
    Ashkan Shoamanesh, Sarah R. Preis, Alexa S. Beiser et al.
    Neurology, January 28, 2015
Neurology: 101 (13)

Articles

  • Ahead of Print
  • Current Issue
  • Past Issues
  • Popular Articles
  • Translations

About

  • About the Journals
  • Ethics Policies
  • Editors & Editorial Board
  • Contact Us
  • Advertise

Submit

  • Author Center
  • Submit a Manuscript
  • Information for Reviewers
  • AAN Guidelines
  • Permissions

Subscribers

  • Subscribe
  • Activate a Subscription
  • Sign up for eAlerts
  • RSS Feed
Site Logo
  • Visit neurology Template on Facebook
  • Follow neurology Template on Twitter
  • Visit Neurology on YouTube
  • Neurology
  • Neurology: Clinical Practice
  • Neurology: Education
  • Neurology: Genetics
  • Neurology: Neuroimmunology & Neuroinflammation
  • AAN.com
  • AANnews
  • Continuum
  • Brain & Life
  • Neurology Today

Wolters Kluwer Logo

Neurology | Print ISSN:0028-3878
Online ISSN:1526-632X

© 2023 American Academy of Neurology

  • Privacy Policy
  • Feedback
  • Advertise