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Is more weight protective? Weight gain and high BMI linked to lower risk of ALS
People who have a high body mass index (BMI) or who gain weight as they get older may have a lower risk of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. “While some cases of ALS are genetic, most cases do not appear to have a genetic cause, and an increasing body of evidence suggests that there may be a link between a fast metabolism that can lead to a low BMI and ALS,” said study author Ola Nakken, MD, of the University of Oslo in Norway. “It is important to note that while our study found a link between high BMI and a lower risk of ALS, it is possible that genetics could make a person more likely to have both a low BMI and a higher risk of ALS without one causing another. People must not interpret the results of our study as a suggestion that gaining weight may prevent ALS. Plus, the health risks of having a high BMI would be greater than any protective effect.”
Nakken O, Meyer HE, Stigum H, Holmøy T. Neurology 2019;93:e424–e432. doi.org/10.1212/WNL.0000000000007861
CME
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