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September 10, 2019; 93 (11) Article

Blood NfL

A biomarker for disease severity and progression in Parkinson disease

Chin-Hsien Lin, Cheng-Hsuan Li, Kai-Chien Yang, Fang-Ju Lin, Chau-Chung Wu, Jen-Jie Chieh, Ming-Jang Chiu
First published August 16, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008088
Chin-Hsien Lin
From the Department of Neurology (C.-H.L., C.-H.L., M.-J.C.), Department of Internal Medicine (K.-C.Y., C.-C.W.), and Department of Pharmacy (F.-J.L.), National Taiwan University Hospital, College of Medicine, National Taiwan University; Department of Pharmacology (K.-C.Y.), Graduate Institute of Clinical Pharmacy & School of Pharmacy (F.-J.L.), and Graduate Institute of Brain and Mind Sciences (M.-J.C.), College of Medicine, National Taiwan University; Institute of Electro-Optical Science and Technology (J.-J.C.), National Taiwan Normal University; and Graduate Institute of Biomedical Engineering and Bioinformatics (M.-J.C.) and Graduate Institute of Psychology (M.-J.C.), National Taiwan University, Taipei.
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Cheng-Hsuan Li
From the Department of Neurology (C.-H.L., C.-H.L., M.-J.C.), Department of Internal Medicine (K.-C.Y., C.-C.W.), and Department of Pharmacy (F.-J.L.), National Taiwan University Hospital, College of Medicine, National Taiwan University; Department of Pharmacology (K.-C.Y.), Graduate Institute of Clinical Pharmacy & School of Pharmacy (F.-J.L.), and Graduate Institute of Brain and Mind Sciences (M.-J.C.), College of Medicine, National Taiwan University; Institute of Electro-Optical Science and Technology (J.-J.C.), National Taiwan Normal University; and Graduate Institute of Biomedical Engineering and Bioinformatics (M.-J.C.) and Graduate Institute of Psychology (M.-J.C.), National Taiwan University, Taipei.
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Kai-Chien Yang
From the Department of Neurology (C.-H.L., C.-H.L., M.-J.C.), Department of Internal Medicine (K.-C.Y., C.-C.W.), and Department of Pharmacy (F.-J.L.), National Taiwan University Hospital, College of Medicine, National Taiwan University; Department of Pharmacology (K.-C.Y.), Graduate Institute of Clinical Pharmacy & School of Pharmacy (F.-J.L.), and Graduate Institute of Brain and Mind Sciences (M.-J.C.), College of Medicine, National Taiwan University; Institute of Electro-Optical Science and Technology (J.-J.C.), National Taiwan Normal University; and Graduate Institute of Biomedical Engineering and Bioinformatics (M.-J.C.) and Graduate Institute of Psychology (M.-J.C.), National Taiwan University, Taipei.
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Fang-Ju Lin
From the Department of Neurology (C.-H.L., C.-H.L., M.-J.C.), Department of Internal Medicine (K.-C.Y., C.-C.W.), and Department of Pharmacy (F.-J.L.), National Taiwan University Hospital, College of Medicine, National Taiwan University; Department of Pharmacology (K.-C.Y.), Graduate Institute of Clinical Pharmacy & School of Pharmacy (F.-J.L.), and Graduate Institute of Brain and Mind Sciences (M.-J.C.), College of Medicine, National Taiwan University; Institute of Electro-Optical Science and Technology (J.-J.C.), National Taiwan Normal University; and Graduate Institute of Biomedical Engineering and Bioinformatics (M.-J.C.) and Graduate Institute of Psychology (M.-J.C.), National Taiwan University, Taipei.
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Chau-Chung Wu
From the Department of Neurology (C.-H.L., C.-H.L., M.-J.C.), Department of Internal Medicine (K.-C.Y., C.-C.W.), and Department of Pharmacy (F.-J.L.), National Taiwan University Hospital, College of Medicine, National Taiwan University; Department of Pharmacology (K.-C.Y.), Graduate Institute of Clinical Pharmacy & School of Pharmacy (F.-J.L.), and Graduate Institute of Brain and Mind Sciences (M.-J.C.), College of Medicine, National Taiwan University; Institute of Electro-Optical Science and Technology (J.-J.C.), National Taiwan Normal University; and Graduate Institute of Biomedical Engineering and Bioinformatics (M.-J.C.) and Graduate Institute of Psychology (M.-J.C.), National Taiwan University, Taipei.
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Jen-Jie Chieh
From the Department of Neurology (C.-H.L., C.-H.L., M.-J.C.), Department of Internal Medicine (K.-C.Y., C.-C.W.), and Department of Pharmacy (F.-J.L.), National Taiwan University Hospital, College of Medicine, National Taiwan University; Department of Pharmacology (K.-C.Y.), Graduate Institute of Clinical Pharmacy & School of Pharmacy (F.-J.L.), and Graduate Institute of Brain and Mind Sciences (M.-J.C.), College of Medicine, National Taiwan University; Institute of Electro-Optical Science and Technology (J.-J.C.), National Taiwan Normal University; and Graduate Institute of Biomedical Engineering and Bioinformatics (M.-J.C.) and Graduate Institute of Psychology (M.-J.C.), National Taiwan University, Taipei.
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Ming-Jang Chiu
From the Department of Neurology (C.-H.L., C.-H.L., M.-J.C.), Department of Internal Medicine (K.-C.Y., C.-C.W.), and Department of Pharmacy (F.-J.L.), National Taiwan University Hospital, College of Medicine, National Taiwan University; Department of Pharmacology (K.-C.Y.), Graduate Institute of Clinical Pharmacy & School of Pharmacy (F.-J.L.), and Graduate Institute of Brain and Mind Sciences (M.-J.C.), College of Medicine, National Taiwan University; Institute of Electro-Optical Science and Technology (J.-J.C.), National Taiwan Normal University; and Graduate Institute of Biomedical Engineering and Bioinformatics (M.-J.C.) and Graduate Institute of Psychology (M.-J.C.), National Taiwan University, Taipei.
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Citation
Blood NfL
A biomarker for disease severity and progression in Parkinson disease
Chin-Hsien Lin, Cheng-Hsuan Li, Kai-Chien Yang, Fang-Ju Lin, Chau-Chung Wu, Jen-Jie Chieh, Ming-Jang Chiu
Neurology Sep 2019, 93 (11) e1104-e1111; DOI: 10.1212/WNL.0000000000008088

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Disputes & Debates: Rapid online correspondence

  • Author response: Blood NfL: A biomarker for disease severity and progression in Parkinson disease
    • Chin-Hsien Lin, Neurologist, National Taiwan University Hospital
    • Ming-Jang Chiu, Neurologist, National Taiwan University Hospital
    Submitted July 07, 2020
  • Reader response: Blood NfL: A biomarker for disease severity and progression in Parkinson disease
    • Anouke van Rumund, MD, Radboudumc
    • Tainá M. Marques, MSc, Radboudumc
    • Rianne A.J. Esselink, MD, PhD, Radboudumc
    • Bastiaan R. Bloem, MD, PhD, Radboudumc
    • Marcel M. Verbeek, PhD, Radboudumc
    Submitted November 22, 2019
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