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September 17, 2019; 93 (12) Clinical/Scientific Notes

Prospective validation of the PML risk biomarker l-selectin and influence of natalizumab extended intervals

Nicholas Schwab, Tilman Schneider-Hohendorf, Béatrice Pignolet, Florence Bucciarelli, Lise Scandella, Jonathan Ciron, Damien Biotti, Christine Lebrun-Frenay, Guillaume Mathey, Pierre Clavelou, Jean Pelletier, Patrick Ostkamp, Ingrid Meinl, Susanne Windhagen, Luisa Klotz, Catharina C. Gross, Sven G. Meuth, Florian Deisenhammer, David Brassat, Heinz Wiendl, on behalf of the Best-MS Study Group
First published August 22, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008135
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Low l-selectin (CD62L) on CD4+ T cells after cryopreservation has been introduced in 2013 as a risk biomarker for the development of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment1 or HIV infection.2 The biomarker has been reproduced retrospectively in some international cohorts,3,4 but not in others,5 potentially because of its sensitivity to biomaterial quality, assay protocols, and the time point of testing. With regard to current approaches to PML risk reduction, natalizumab extended interval dosing is thought to improve immune surveillance and reduce PML risk, whereas clinical efficacy seems unaffected.6

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • ↵* These authors contributed equally.

  • The coinvestigators are listed at links.lww.com/WNL/A979.

  • Received February 8, 2019.
  • Accepted in final form June 25, 2019.
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