Postictal serotonin levels are associated with peri-ictal apnea
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Article Information
- Received September 27, 2018
- Accepted in final form May 15, 2019
- First Published September 4, 2019.
Article Versions
- Previous version (September 4, 2019 - 12:45).
- You are viewing the most recent version of this article.
Author Disclosures
- Arun Murugesan, BA,
- M.R. Sandhya Rani, PhD,
- Laura Vilella, MD,
- Nuria Lacuey, MD, PhD,
- Johnson P. Hampson, MS,
- Carl L. Faingold, PhD,
- Daniel Friedman, MD,
- Orrin Devinsky, MD,
- Rup K. Sainju, MBBS,
- Stephan Schuele, MD, MPH,
- Beate Diehl, MD, PhD, FRCP,
- Maromi Nei,
- Ronald M. Harper, PhD,
- Lisa M. Bateman, MD,
- George Richerson, MD, PhD and
- Samden D. Lhatoo, MD, FRCP
- Arun Murugesan, BA,
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- M.R. Sandhya Rani, PhD,
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- Laura Vilella, MD,
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NIH/NINDS U01-NS090405 NIH/NINDS U01-NS090407
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- Nuria Lacuey, MD, PhD,
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- Johnson P. Hampson, MS,
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- Carl L. Faingold, PhD,
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Methods for treating respiratory depression with fenfluramine
Faingold CL, Blumenfeld H. eds. Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics. San Diego, CA: Elsevier/Academic Press; 2014
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Zogenix Inc
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Epilepsy Foundation (287813)
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- Daniel Friedman, MD,
(1) Receptor Life Sciences
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(1) Medtronics (2) Neuropace, Inc (3) Epilepsy Foundation of America
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(1) Subgaleal EEG monitor, patent pending
(1) Oxford University Press
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(1) Eisai (2) Penumbra (3) Consultancy on behalf of the Epilepsy Study Consortium, a non-profit organization. Dr. Friedman receives no personal income for these activities. NYU receives a fixed amount from the Epilepsy Study Consortium towards Dr. FriedmanÂs salary. Within the past two years, The Epilepsy Study Consortium received payments for research services performed by Dr. Friedman from: Adamas, Biogen, Crossject, CuroNZ, Empatica, Engage Pharmaceuticals, Eisai, GW Pharmaceuticals, Pfizer, Takeda, Xenon, and Zynerba.
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(1) Neuropace (2) Empatica (3) Epitel (4) UCB, Inc
NINDS, R01 NS062092, Site PI, 2018-2023 NINDS, R01 NS084142, Site PI, 2013-2018 NINDS, U01 NS090407, Site PI 2014-2019 NINDS, U01 NS0904515, Co-I, 2014-2019 NIMH, R01 MH07396, Co-I, 2015-2020 CDC, U48, DO005008-01S4, Co-I, 2014-2019
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(1) Epilepsy Foundation of America
(1) Neuroview Technology, equity interest
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(1) Neuroview Technology, future royalty payments Stock/Stock Options, Medical Equipment & Materials: (1) Receptor Life Sciences, stock options
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- Orrin Devinsky, MD,
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Cognitive and Behavioral Neurology; Oxford University Press, 2002 Epilepsy: Patient and Family Guide, Demos Press, 2008 Alternative Therapies for Epilepsy, Demos Press, 2012 Epilepsy In Children, Demos Press, 2015
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I have consulted for GW Pharmaceuticals and Cavion
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Scientific Advisory Board and/or Equity Interest for Pairnomix, Tevard, Egg Rock, Engage, Empatica, Rettco, Receptor Life Sciences and Tilray. Principal Investigator, North American SUDEP Registry and Sudden Unexplained Childhood Death Registry and Research Collaborative Funded by NINDS, NIMH, Dept of Defense, CDC
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For research support: GW Pharmaceuticals Novartis Marinus PTC Pharma Ovid Pharma Engage Therapeutics Epilepsy Foundation
Ongoing Support NIH U01 NS090407 (PI: S. Lhatoo) 09/30/14 Â 7/31/2019 Center for SUDEP Research: Autonomic and Imaging Biomarkers of SUDEP The principal aim is to identify the central mechanisms and markers of autonomic and respiratory dysfunction that underlie the fatal scenario in SUDEP, and thus, provide insights into potential interventions. Role: Co-Investigator NIH U01 NS090415 (PIs: M. Thom, O. Devinsky) 9/30/14 Â 7/31/2019 Center for SUDEP Research: The Neuropathology of SUDEP: The central autonomic network, serotonin and adenosine The proposed studies will leverage the worldÂs largest collection of SUDEP brains to explore the role of specific histopathological and biomolecular abnormalities in the brain, focusing on critical brainstem regions and the neurotransmitters serotonin and adenosine. Role: PI National Center for Chronic Disease Prevention and Promotion U48 DP 005008-01S4 (PIs: T. Spruill, O. Devinsky) 9/1/2014 Â 8/31/2019 Managing Epilepsy Well: Adapting Project UPLIFT for Hispanic Adults with Epilepsy This project proposes to translate and culturally tailor Project UPLIFT for Hispanic patients, then test and disseminate the Spanish version. Project UPLIFT is an evidence-based intervention that incorporates cognitive behavioral and mindfulness techniques to reduce depression in adults with epilepsy. Role: Co-Investigator NIH R01 EB 018308 (PIs: K.T. Block, H. Chandarana) 9/1/2014 - 8/31/2019 Comprehensive Motion-Robust Pediatric MR Imaging Using Radial Acquisitions The proposed project aims to develop novel motion-robust magnetic resonance imaging techniques and evaluate them in clinical studies for imaging of pediatric patients with Tuberous Sclerosis. Role: Co-Investigator
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Rettco - Stock Tevard - Stock Engage - Stock Pairnomix - Stock Tilray - Stock Options Receptor Life Sciences - Stock Egg Rock - Stock Empatica - Stock Rettco - Stock
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- Rup K. Sainju, MBBS,
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NINDS: Center for SUDEP Research: Respiratory and Arousal Mechanisms; Grant number# U01 NS090414. Role: Co-investigator
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Citizen United For Research in Epilepsy (CURE): CURE Epilepsy Award; Award ID # 411673,
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- Stephan Schuele, MD, MPH,
(1) Non-profit entities: Epilepsy Foundation of Greater Chicago
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(1) Medical Problems of Performing Artists: Editorial Board (2) Journal of Clinical Neurophysiology: Editorial Board
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(1)Sunovion (2)Eisai (3)Greenwich Biosciences
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(1)National Institute of Neurologic Disorders and Stroke (NINDS). Grant No: RFA-NS-14-004; Site-PI. 2014- 2019 (2) National Institute on Deafness and Other Communication Disorders. Grant No: R01-DC016364. Sub-PI. 2018-2023.
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Danny Did Foundation.
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- Beate Diehl, MD, PhD, FRCP,
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Seizure, European Journal of Epilepsy , Editorial Board member from 2011 Nervenarzt, Editorial Board member from 2011
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1. Epilepsy Research UK,PGE1302, PI, 2013-15. 2. NIH-NINDS Subaward RES508546, Local PI, 2013/14. 3.NIH-NINDS UO1NS090407; Subaward RES509426, Co-PI, 2014-2019
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- Maromi Nei,
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Editorial board member: Journal of Neurology and Neurophysiology, editorial board member, 2010 - present Journal of Neurology and Translational Neuroscience, 2013 Â current, editorial board member Epilepsia, 2018, editorial board member
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NIH grant U-01 NS090407, Site PI, 2014-present
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- Ronald M. Harper, PhD,
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Kraig and Linda Kupiec Family Trust; Gift to support research efforts in migraine pain, private family gift
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Frontiers Autonomic Neuroscience, Editorial advisory board, 2017-2018, Frontiers Autonomic Neuroscience
1. PCT International Application No. PCT/US14/47642, filed July 22, 2014 Device, System and Method for Facilitating Breathing via Simulation of Limb Movement. Published January 29, 2015 Device uses neuromodulatory techniques to maintain breathing and prevent apnea 2. PCT Patent Application No. PCT/US14/66191, filed November 18, 2014. Device, System and Method for Reducing Headache Pain. Published May 21, 2015. Device uses neuromodulation of cranial and cervical nerves to reduce migraine and trigeminal neuropathy pain. 3. PCT/US2017/032214, WO 2017/197150. Priority Data 11 May 2016. Device, system and method for mechanical cutaneous nerve stimulation for pain, stroke, mood, breathing, movement, sleep, and vascular action. Published 16 November 2017. Devices use neuromodulatory techniques of peripheral nerve activation to reduce regional pain, induce sleep, stabilize breathing, suppress movement, and reduce blood pressure and heart rate.
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NIH/NINDS U01-NS090407, PI, 2014-2019, NIH/NINDS NIH/NINR 1R01 NR015038-01A1 Co-I, 2015-2019, NIH/NINR NIH/NINR 1R01NR013693-01A1, Co-I, 2013-2018 NIH/NINR
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1. Fidelity Charitable Nancy Adams and Scott Schoen Fund
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Contractual rights to future royalty payments from PCT International Application No. PCT/US14/47642 Device, System and Method for Facilitating Breathing via Simulation of Limb Movement. Contractual rights to future royalty payments: PCT Patent Application No. PCT/US14/66191. Device, System and Method for Reducing Headache Pain. Contractual rights to future royalty payments: Device, system and method for mechanical cutaneous nerve stimulation for pain, stroke, mood, breathing, movement, sleep, and vascular action.
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- Lisa M. Bateman, MD,
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Clinical Neurophysiology, Editorial Board Member, 2017- 2019 (no compensation)
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1. NINDS, U01 NS090407, Co-investigator, 2014-2019 2. NINDS, R01 NS084142, Co-investigator, 2018-2019
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- George Richerson, MD, PhD and
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(1) NIH/NINDS Â U01 NS090414, PI, 2014-2019 (2) NIH/NINDS Â U01 NS090407, SubContract, 2014-2019
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- Samden D. Lhatoo, MD, FRCP
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NIH/NINDS U01-NS090405 NIH/NINDS U01-NS090407
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- From the Department of Neurology (A.M.), Case Western Reserve University; Department of Neurology (M.R.S.R., L.V., N.L., J.P.H., S.D.L.), McGovern Medical School, University of Texas Health Science Center at Houston; Department of Pharmacology and Neurology (C.L.F.), Southern Illinois University School of Medicine, Springfield; Department of Neurology (D.F., O.D.), New York University School of Medicine, New York; Department of Neurology (R.K.S., G.R.), University of Iowa Carver College of Medicine, Iowa City; Department of Neurology (S.S.), Northwestern University Feinberg School of Medicine, Chicago, IL; Institute of Neurology (B.D.), University College London, UK; Department of Neurology (M.N.), Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA; Department of Neurobiology (R.M.H.), David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Neurology (L.M.B.), Columbia University Medical Center, New York, NY; and Center for SUDEP Research (M.R.S.R., L.V., N.L., D.F., O.D., R.K.S., S.S., B.D., M.N., R.M.H., L.M.B., G.R., S.D.L.), National Institute for Neurological Disorders and Stroke, Bethesda, MD.
- Correspondence
Dr. Rani M.R.Sandhya.Rani{at}uth.tmc.edu
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