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November 05, 2019; 93 (19) Article

Clinical and neural responses to cognitive behavioral therapy for functional tremor

Alberto J. Espay, Scott Ries, Thomas Maloney, Jennifer Vannest, Erin Neefus, Alok K. Dwivedi, Jane B. Allendorfer, Lawson R. Wulsin, W. Curt LaFrance, Anthony E. Lang, Jerzy P. Szaflarski
First published October 4, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008442
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Article Information

vol. 93 no. 19 e1787-e1798
DOI: 
https://doi.org/10.1212/WNL.0000000000008442
PubMed: 
31586023
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received March 6, 2019
  • Accepted in final form June 19, 2019
  • First Published October 4, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Alberto J. Espay, MD, MSc,
    2. Scott Ries, LISW,
    3. Thomas Maloney, MS,
    4. Jennifer Vannest, PhD,
    5. Erin Neefus, BS, CCRP,
    6. Alok K. Dwivedi, PhD,
    7. Jane B. Allendorfer, PhD,
    8. Lawson R. Wulsin, MD,
    9. W. Curt LaFrance, Jr, MD, MPH,
    10. Anthony E. Lang, MD, FRCPC and
    11. Jerzy P. Szaflarski, MD, PhD
  1. Alberto J. Espay, MD, MSc,
    2. Scientific Advisory Boards:

    1. Abbvie, NeuroDerm, TEVA, Impax, Acadia, Acorda, Cynapsus/Sunovion, Lundbeck, Osmotica Pharmaceutical, and USWorldMeds

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial board member of the Journal of Parkinson’s Disease and Parkinsonism and Related Disorders.

    Patents:

    1. NONE

    Publishing Royalties:

    1. Lippincott Williams & Wilkins, Cambridge University Press, and Springer.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Consultant for Abbvie, NeuroDerm, TEVA, Impax, Acadia, Acorda, Cynapsus/Sunovion, Lundbeck, Osmotica Pharmaceutical, and USWorldMeds

    Speakers' Bureaus:

    1. Abbvie, UCB, USWorldMeds, Lundbeck, Acadia, the American Academy of Neurology, and the Movement Disorders Society

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NIH

    Research Support, Academic Entities:

    1. Great Lakes Neurotechnologies

    Research Support, Foundations and Societies:

    1. Michael J Fox Foundation, Davis Phinney Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. Scott Ries, LISW,
    3. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Thomas Maloney, MS,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Jennifer Vannest, PhD,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Erin Neefus, BS, CCRP,
    6. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Alok K. Dwivedi, PhD,
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Jane B. Allendorfer, PhD,
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. (1) Restorative Neurology and Neuroscience, Reviewer, 2017-present (2) Clinical Therapeutics, Guest Editor, 2017

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. (1) LivaNova, Inc.

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) Alabama Department of Commerce, (no grant number), Sub-Investigator, 2014-2019 (2) Department of Defense, W81XH-17-0619, Sub-Investigator, 2017-2021

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) The Evelyn F. McKnight Brain Institute

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  8. Lawson R. Wulsin, MD,
    9. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. 1) Psychosomatic Medicine, 2017-present, editorial board member 2) Psychosomatics, 2009-present, editorial board member 3) J Psychosomatic Research, 2016, editorial board member 4) General Hospital Psychiatry, 2010 editorial board member

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  9. W. Curt LaFrance, Jr, MD, MPH,
    10. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Editorial Board for Epilepsia and for Epilepsy and Behavior; Journal of Neurology, Neurosurgery and Psychiatry; Journal of Neuropsychiatry and Clinical Neurosciences

    Patents:

    1. NONE

    Publishing Royalties:

    1. Gates and Rowan's Nonepileptic Seizures, Cambridge University Press, 2018 Taking Control Of Your Seizures: Workbook and Therapist Guide, Oxford University Press, 2015

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Department of Defense, W81XWH-17-0169, Neuroimaging Biomarker for Seizures, Role: PI, 9/30/17-8/31/21

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. medico-legal expert work

  10. Anthony E. Lang, MD, FRCPC and
    11. Scientific Advisory Boards:

    1. Abbvie, Acorda, Biogen, Bristol Myers Squibb, Intracellular, Janssen, Jazz, PhotoPharmics, Sunovion, Lilly, Lundbeck, Merck, Ono, Paladin, Roche, Seelos, Syneos, Sun Pharma, Theravance, and Corticobasal Degeneration Solutions.

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. Sun Pharma, Medichem, Medtronic, AbbVie and Sunovion

    Editorial Boards:

    1. Movement Disorders:Clinical Practice Journal of Neurology, Neurosurgery and Psychiatry

    Patents:

    1. NONE

    Publishing Royalties:

    1. Schapira A, Lang AE, Fahn S. Movement Disorders 4. Saunders, Elsevier, Philadelphia, PA 2009. Olanow CW, Stocchi F, Lang AE. The Non-motor and Non- Dopaminergic Features of Parkinson’s Disease. Wiley- Blackwell, UK. 2011. Weiner WJ, Shulman LM, Lang AE. Parkinson’s Disease: A Complete Guide for Patients and Families. The Johns Hopkins University Press, Baltimore. 2001 Receives publishing royalties from Cambridge University Press.

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. Parkinson's UK Corticobasal Degeneration Solutions MSA Coalition Defeat MSA

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Brain Canada, Canadian Institutes of Health Research Ontario Brain Institute

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Edmond J Safra Philanthropic Foundation, Michael J. Fox Foundation, Parkinson Foundation, Parkinson Canada, W. Garfield Weston Foundation

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  11. Jerzy P. Szaflarski, MD, PhD
    12. Scientific Advisory Boards:

    1. UCB Pharmaceuticals, Inc SK Life Sciences, Inc GW Pharmaceuticals, Inc

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. SK Life Sciences, Inc UCB Pharmaceuticals, Inc GW Pharmaceuticals, Inc

    Editorial Boards:

    1. Contributing Editor, Epilepsy Currents Associate Editor, Journal of Epileptology Editorial Board Member, Folia Medica Copernicana Editorial Board Member, Journal of Medical Science Associate Editor, Restorative Neurology and Neuroscience Editorial Board Member, Conference Papers in Medicine Editorial Board Member, Epilepsy and Behavior

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical procedures or imaging studies:

    1. 100% of my clinical practice is related to diagnosing and treating patients with epilepsy

    Research Support, Commercial Entities:

    1. SAGE Pharmaceuticals Inc., GW Pharmaceuticals Inc., NeuroPace Inc., UCB Pharmaceuticals Inc,

    Research Support, Government Entities:

    1. NIH R21 MH103828 (Consultant), NIH R01 MH102951 (Co-Investigator), DoD PT130232 (Co-PI), NIH K23 EB008452 (mentor), NIH R01 NS080898 (Co-Investigator), NIH R01 HD068488 (PI), EQUIGEN studies - University of Cincinnati (site PI), NIH K23 MH092735 (mentor), NIH R01 NS065840 (subcontract PI), NIH R01 NS035929 (subcontract PI), NIH R01 NS048281 (PI); National Science Foundation (OIA - 1632891)

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Charles Shor Foundation for Epilepsy Research (PI)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. Medico-legal expert

  1. From the Gardner Family Center for Parkinson's Disease and Movement Disorders (A.J.E., E.N.); Mood Disorders Center (S.R., L.R.W.), University of Cincinnati Gardner Neuroscience Institute; Pediatric Neuroimaging Research Consortium (T.M., J.V.), Cincinnati Children's Hospital; Department of Pediatrics (J.V.), University of Cincinnati College of Medicine, OH; Department of Biomedical Sciences (A.K.D.), Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso; Department of Neurology (J.B.A., J.P.S.), University of Alabama at Birmingham; Division of Neuropsychiatry and Behavioral Neurology (W.C.L.), Rhode Island Hospital, Providence; and Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic (A.E.L.), Toronto Western Hospital, University of Toronto, Ontario, Canada.
  1. Correspondence
    Dr. Espay alberto.espay{at}uc.edu
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