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November 12, 2019; 93 (20) Article

Relation between 20-year income volatility and brain health in midlife

The CARDIA study

Leslie Grasset, M. Maria Glymour, Tali Elfassy, Samuel L. Swift, Kristine Yaffe, Archana Singh-Manoux, Adina Zeki Al Hazzouri
First published October 2, 2019, DOI: https://doi.org/10.1212/WNL.0000000000008463
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Article Information

vol. 93 no. 20 e1890-e1899
DOI: 
https://doi.org/10.1212/WNL.0000000000008463
PubMed: 
31578298
Published By: 
Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology
Print ISSN: 
0028-3878
Online ISSN: 
1526-632X
History: 
  • Received January 18, 2019
  • Accepted in final form June 24, 2019
  • First Published October 2, 2019.

Article Versions

Copyright & Usage: 
© 2019 American Academy of Neurology

Author Disclosures

    1. Leslie Grasset, PhD,
    2. M. Maria Glymour, ScD,
    3. Tali Elfassy, PhD,
    4. Samuel L. Swift, MPH,
    5. Kristine Yaffe, MD,
    6. Archana Singh-Manoux, PhD and
    7. Adina Zeki Al Hazzouri, PhD
  1. Leslie Grasset, PhD,
    2. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  2. M. Maria Glymour, ScD,
    3. Scientific Advisory Boards:

    1. Organizing committee for the MEthods in Longitudinal Research on DEMentia (MELODEM) initiative (no compensation, travel expenses and lodging at the meeting)

    Gifts:

    1. NONE

    Funding for travel or speaker honoraria:

    1. non-profit entities, paid for travel: - Institut de Santé Publique, d'Epidémiologie et de Developpement,Université Victor Segalen Bordeaux 2 (no compensation, just travel expenses) - Drexel University - Columbia University - University of Wisconsin - Duke University - Emory University

    Editorial Boards:

    1. J Causal Inference, Associate editor, 2016- PLOS one, Academic editor, 2012- American Journal of Epidemiology, Associate Editor 2015- (no compensation for any)

    Patents:

    1. NONE

    Publishing Royalties:

    1. Social Epidemiology, 2nd edition, Oxford University Press 2014

    Employment, Commercial Entity:

    1. I have been a full time employee of the University of California, San Francisco, as an associate professor or professor, for over 5 years.

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. Past: NIH/NIA, Co-I, 9/31/2011-8/31/2016; (6) NIH/NICHD, Co- I; 7/1/10 - 6/31/12; (7) Office for Minority Health and Health Disparities, NIH; Role: Co-I; (8) NIH/NIA, Co-I, 9/1/2011-8/31/2016; NIH/NIA, Co-I, 10/1/2010-9/31/2012; Current: No number available 04/01/18-03/31/20 Robert Wood Johnson Foundation Evidence for Action National Program Office Associate Director 1R01AG051170 09/15/15-05/31/20 NIH/NIA Co-I 1RF1AG052132 06/01/16-05/31/21 NIH/NIA mPI RF1AG056164 09/01/16-06/30/21 NIH/NIA Co-I 1RF1AG050782-01A1 01/01/17-12/31/21 NIH/NIA Co-I RF1AG055486 06/15/17-05/31/21 NIH/NIA mPI R01EY027004 07/01/2017-05/31/2021 NIH/NEI co-I RF1AG056519 (Whitmer) 07/01/2017-06/30/2022 NIH/NIA Co-I P01AG041710 (Berkman) 09/30/2017-05/31/2022 NIH/NIA Co-I 1R01AG054066-01A1 (Berkman) 9/1/2018-8/31/2023 NIH/NIA Co-I R01AG057869 (Glymour/Power) 09/01/2018-04/30/2023 NIH/NIA mPI R01AG059872 (Glymour) 08/15/2018-04/30/2022 NIH/NIA PI R56AG062165 (Portacolone) 09/01/2018 – 08/31/2019 NIH/NIA Co-I R01DK116738 (Jorgenson/Ahituv) 09/15/2018-08/31/2021 NIH/NEI Co-I 1R01HD090014 (Osypuk) 09/19/2017-05/31/2021 NIH/NICHD Co-I 7R01AG056360-02 (Yen) 07/01/2017-06/30/2021 NIH/NIA Co-I 1R01AG063385-01A1 (Hamad) 04/01/2019 – 03/31/2024 NIH/NIA Co-I P30 AG062422 (Miller) 04/01/2019 – 03/31/2024 NIH/NIA Co-I

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. (1) American Heart Association Scientist Development Grant #10SDG2640243, PI, 1/1/10 – 12/31/14 (2) Robert Wood Johnson Foundation, Evidence for Action Grants Program, associate director, 2015-(this supports part of my salary)

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  3. Tali Elfassy, PhD,
    4. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. American Heart Association 17POST32490000

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  4. Samuel L. Swift, MPH,
    5. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. American Heart Association, Grant ##19PRE34380576

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  5. Kristine Yaffe, MD,
    6. Scientific Advisory Boards:

    1. 1)DSMB for Eli Lilly 2)DSMBs for NIH sponsored study 3)Beeson Scientific Advisory Board 4)Global Council on Brain Health Governance Committee

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. -Associate Editor, 2011-, International Review of Psychiatry -Editorial Board Member 2014-, Journal of Prevention of Alzheimer’s Disease - Editorial Board Member 2017-, Alzheimer’s & Dementia: Translational Research & Clinical Interventions - Editorial Board Member 2018-, Translational Neurodegeneration

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. 1. K24 AG031155 (PI) NIA Predictors of cognitive aging across the lifecourse 06/13-11/20 2. Director Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center Psychiatric Fellowship 10/09-09/23 3. PI of Dementia Research at SF VA Medical Center Sierra-Pacific VISN Mental Illness Research, Educational and Clinical Center 10/09-09/23 4. (Co-Investigator, PI: Cifu) Department of Defense/VA Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 07/13-09/19 5. W81XWH-14-2-0137 (PI: Yaffe) Department of Defense Blood biomarker profile of TBI-associated cognitive impairment among old & young veterans 10/14-09/19 6. W81XWH-14-2-0176 (Co-Investigator, PI: Manley) Department of Defense Traumatic Brain Injury Endpoints Development (TED) Award 10/14-09/19 7. R01 HL122658 (Multiple PI: Yaffe and Sidney) NHLBI Determinants of Midlife & Longitudinal Change in Cognitive Function 12/14-11/19 8. W81XWH-12-PHTBI-CENC (PI: Yaffe) Department of Defense/VA Epidemiology Project. Chronic Effects of Neurotrauma Consortium (Military and Veterans Rehabilitation and Recovery from Injury Network) 02/15-09/19 9. R01 AG048234 (Co-investigator, PI: Kramer) NIA Effects of Chronic Inflammation on Brain Structure and Function 04/15-01/20 10. R01 AG032289 (Co-investigator, PI: Kramer) NIA Biological predictors of brain aging trajectories 09/15-05/20 11. R01 AG052964 (Co-investigator, PI: Cummings) NIA Comprehensive Evaluation of Aging-Related Clinical Outcomes and Geroproteins 06/16-05/21 12. RF1 G050745 (Co-investigator, PI: Spira) NIA The ARIC study of midlife sleep and late-life brain amyloid 06/16-05/21 13. UL1 TR991872 (Director of Pilot Grants Program, PI: Grandis) National Center for Advancing Translational Sciences Clinical and Translational Science Institute 07/16-06/21 14. W81XWH-16-1-0507 (PI: Yaffe) Department of Defense Risk and Resiliency for Dementia: Comparison of Male and Female Veterans 08/16-08/19 15. RF1 AG054443 (Multiple PI: Yaffe and Zeki-Al Hazzouri) NIA Healthy Heart, Healthy Brain? A Pooled Life-course Cohort for Dementia Risk Assessment 05/17-04/21 16. R01 AG054073 (Multiple PI: Yaffe/O’Bryant/Toga) NIA Health Disparities in Alzheimer’s Disease and Mild Cognitive Impairment among Mexican Americans 09/17-05/22 17. R01 AG057508 (Multiple PI: Yaffe/Larson) NIA Systematic Multi-Domain Alzheimer’s Risk Reduction Trial 09/17-05/21 18. R13 AG058415 (Multiple PI: Yaffe/Gill) American Federation for Aging Research Paul B Beeson Emerging Leaders Career Development Awards in Aging Annual Meeting 09/17-05/22 19. R01 AG058537 (Multiple PI: Yaffe/O’Bryant) NIA An Alzheimer’s Blood Test for Primary Care 6/18-5/21 20. P30 AG044281 (Co-Investigator, PI: Covinsky) NIA UCSF Older American Independence Center 07/18-06/23 21. W81XWH-18-1-0692 (Multiple PI: Yaffe/Plassman) Department of Army Genetics, comorbidities, and ethnicity: Effects of TBI on Dementia 9/18-09/21 22. P30 AG062422 (REC Core PI and Data Core Co- Investigator; PI: Miller) NIH New Approaches to Dementia Heterogeneity (Alzheimer’s Disease Research Centers) 04/19-03/24

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. 1)Doris Duke Charitable Foundation Doris Duke Fund to Retain Clinical Scientists 2) Alzheimer’s Drug Discovery Foundation Connection Between Depressive Symptoms and Dementia:When Best to Intervene? 3)2018-A-006-NET (Co-Investigator, PI: Kramer) Larry L. Hillblom Foundation Hillblom Network for the Prevention of Age-Associated Cognitive Decline

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  6. Archana Singh-Manoux, PhD and
    7. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. Journal of Epidemiology & Community Health (Associate Editor, since 2011)

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. (1) MRC UK K013351, Co-I, 2012-2016; (2) NIH/NIA R01AG013196, PI, 2009-2014; (3) NIH/NIA R01AG034454, PI, 2009-2014; (4) MRC UK K013351, Co-I, 2013-2017; (5) MRC UK MR/S011676, Co-I, 2019-2022; (6) MRC UK MR/R024227, Co-I, 2018-2023; (7) NIH/NIA R01AG056477 , PI, 2018-2023; (8) NIH/NIA R56AG056477, PI, 2017-2018

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. Fondation Bettencourt

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  7. Adina Zeki Al Hazzouri, PhD
    8. Scientific Advisory Boards:

    1. NONE

    Gifts:

    1. NONE

    Funding for Travel or Speaker Honoraria:

    1. NONE

    Editorial Boards:

    1. NONE

    Patents:

    1. NONE

    Publishing Royalties:

    1. NONE

    Employment, Commercial Entity:

    1. NONE

    Consultancies:

    1. NONE

    Speakers' Bureaus:

    1. NONE

    Other Activities:

    1. NONE

    Clinical Procedures or Imaging Studies:

    1. NONE

    Research Support, Commercial Entities:

    1. NONE

    Research Support, Government Entities:

    1. NONE

    Research Support, Academic Entities:

    1. NONE

    Research Support, Foundations and Societies:

    1. NONE

    Stock/Stock Options/Board of Directors Compensation:

    1. NONE

    License Fee Payments, Technology or Inventions:

    1. NONE

    Royalty Payments, Technology or Inventions:

    1. NONE

    Stock/Stock Options, Research Sponsor:

    1. NONE

    Stock/Stock Options, Medical Equipment & Materials:

    1. NONE

    Legal Proceedings:

    1. NONE

  1. From Université de Bordeaux (L.G.), INSERM, Bordeaux Population Health Research Center, Team VINTAGE UMR1219; Inserm (L.G.), CIC1401-EC, Bordeaux, France; Departments of Epidemiology and Biostatistics (M.M.G., K.Y.), Psychiatry (K.Y.), and Neurology (K.Y.), University of California San Francisco; Division of Epidemiology, Department of Public Health Sciences (T.E., S.L.S.), University of Miami, FL; INSERM U1018 (A.S.-M.), Centre for Research in Epidemiology and Population Health, Paris, France; Department of Epidemiology and Public Health (A.S.-M.), University College London, UK; and Department of Epidemiology (A.Z.A.H.), Mailman School of Public Health, Columbia University, New York, NY.
  1. Correspondence
    Dr. Grasset leslie.grasset{at}u-bordeaux.fr
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